Identification of key metabolites of tectorigenin in rat urine by HPLC-MSn

Biomedical Chromatography

Volumn 23, Issue 2, 2009, Pages 219-221

  Zhang, Wei Dong ^a   Yang, Xiao Lin ^a   Lei Xu, ^a   Cao, Jun ^a   Li, Ping ^a   Yang, Zhong Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

HPLC ESI MSn; Metabolite; Rat urine; Tectorigenic

Indexed keywords

BIOMOLECULES; BODY FLUIDS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PHASE SEPARATION; RATS;

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC-ESI MS; HPLC-ESI-MSN; HPLC-MS; ION TRAPS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; RAT URINE; SUPERNATANTS; TANDEM MASS SPECTROMETRIC; TECTORIGENIC;

METABOLITES;

ACETONITRILE; BELAMCANDAE EXTRACT; FORMIC ACID; PLANT EXTRACT; TECTORIGENIN; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; BELAMCANDAE; CENTRIFUGATION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; MALE; MEDICINAL PLANT; NEGATIVE ION ELECTROSPRAY; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RHIZOME; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; SUPERNATANT; TANDEM MASS SPECTROMETRY; URINALYSIS;

RATTUS;

EID: 65349151447     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1084     Document Type: Article

References (9)

1. Appolpnova SA, Shpak AV and Semenov VA. Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of mesocarb and its metabolites in human urine. Journal of Chromatography B 2004; 800: 281-289.
2. Chan W, Cui L, Xu GW and Cai ZW. Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquidchromatography/ tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2006; 20: 1755-1760.
3. Gu JK, Zhong DF and Chen XY. Analysis of O-glucuronide conjugates in urine by electrospray ion trap mass spectrometry. Journal of Analytical Chemistry 1999; 365: 553-558.
4. Jung SH, Lee YS, Lee S, Lim SS, Kim YS and Shin KH. Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues. Archives of Pharmacal Research 2002; 25: 306-312.
5. Kim YP, Yamada M, Lim SS, Lee SH, Ryu N, Shin KH and Ohuchi K. Inhibition by tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages. Biochimica et Biophysica Acta 1999; 1438: 399-407.
6. Lee SO, Woo WS and Kim KS. Isoflavonoids of Belamcanda chinensis. Korean Journal of Pharmacognosia 1989; 20: 219-222.
7. Moon HI, Jung JC and Lee J. Aldose reductase inhibitory effect by tectorigenin derivatives from Viola hondoensis. Bioorganic and Medicinal Chemistry 2006; 14: 7592.
8. Shin KH, Kim YP, Lim SS, Ryu N, Yamada M and Ohuchi K. Inhibition of prostaglandin E2 production by the isoflavones tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis. Planta Medica 1999; 65: 776-777.
9. Thelen P, Seseke F, Ringert RH, Wuttke W and Seidlová-Wuttke D. Pharmacological potential of phytoestrogens in the treatment of prostate cancer. Urologe-Ausgabe A 2006; 45: 195-201.