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Volumn 66, Issue 2, 2012, Pages 251-264

Biofilm dispersal cells of a cystic fibrosis Pseudomonas aeruginosa isolate exhibit variability in functional traits likely to contribute to persistent infection

Author keywords

Adaptation; Biofilm; Phenotypic variation; Pseudomonas aeruginosa

Indexed keywords

CARBON; ELASTASE; PROTEINASE;

EID: 84867692716     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2012.01006.x     Document Type: Article
Times cited : (27)

References (60)
  • 2
    • 72249092095 scopus 로고    scopus 로고
    • Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal
    • Barraud N, Schleheck D, Klebensberger J, Webb JS, Hassett DJ, Rice SA & Kjelleberg S (2009) Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal. J Bacteriol 191: 7333-7342.
    • (2009) J Bacteriol , vol.191 , pp. 7333-7342
    • Barraud, N.1    Schleheck, D.2    Klebensberger, J.3    Webb, J.S.4    Hassett, D.J.5    Rice, S.A.6    Kjelleberg, S.7
  • 3
    • 14044254215 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent
    • Bjarnsholt T, Jensen P, Burmolle M et al. (2005) Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology 151: 373-383.
    • (2005) Microbiology , vol.151 , pp. 373-383
    • Bjarnsholt, T.1    Jensen, P.2    Burmolle, M.3
  • 4
    • 77954649223 scopus 로고    scopus 로고
    • Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients
    • Bjarnsholt T, Jensen PO, Jakobsen TH et al. (2010) Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients. PLoS ONE 12: e10115.
    • (2010) PLoS ONE , vol.12
    • Bjarnsholt, T.1    Jensen, P.O.2    Jakobsen, T.H.3
  • 5
    • 0346505482 scopus 로고    scopus 로고
    • New concepts of the pathogenesis of cystic fibrosis lung disease
    • Boucher RC (2004) New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 23: 146-158.
    • (2004) Eur Respir J , vol.23 , pp. 146-158
    • Boucher, R.C.1
  • 8
    • 0037635296 scopus 로고    scopus 로고
    • Selection of small colony-variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells
    • Cano DA, Pucciarelli MG, Martinez-Moya M, Casadesus J & Garcia-del Portillo F (2003) Selection of small colony-variants of Salmonella enterica serovar typhimurium in nonphagocytic eucaryotic cells. Infect Immun 71: 3690-3698.
    • (2003) Infect Immun , vol.71 , pp. 3690-3698
    • Cano, D.A.1    Pucciarelli, M.G.2    Martinez-Moya, M.3    Casadesus, J.4    Garcia-del Portillo, F.5
  • 9
    • 0032908465 scopus 로고    scopus 로고
    • The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms
    • Ceri H, Olson ME, Stremick CA, Read RR, Morck D & Buret A (1999) The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol 37: 1771-1776.
    • (1999) J Clin Microbiol , vol.37 , pp. 1771-1776
    • Ceri, H.1    Olson, M.E.2    Stremick, C.A.3    Read, R.R.4    Morck, D.5    Buret, A.6
  • 10
    • 67650924526 scopus 로고    scopus 로고
    • Role of mutation in Pseudomonas aeruginosa biofilm development
    • Conibear TCR, Collins SL & Webb JS (2009) Role of mutation in Pseudomonas aeruginosa biofilm development. PLoS ONE 4: e6289.
    • (2009) PLoS ONE , vol.4
    • Conibear, T.C.R.1    Collins, S.L.2    Webb, J.S.3
  • 11
    • 34247333058 scopus 로고    scopus 로고
    • Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients
    • D'Argenio DA, Wu M, Hoffman LR et al. (2007) Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol 64: 512-533.
    • (2007) Mol Microbiol , vol.64 , pp. 512-533
    • D'Argenio, D.A.1    Wu, M.2    Hoffman, L.R.3
  • 12
    • 0035140062 scopus 로고    scopus 로고
    • Initiation of biofilm formation by Pseudomonas aeruginosa 57RP correlates with emergence of hyperpiliated and highly adherent phenotypic variants deficient in swimming, swarming and twitching motilities
    • Déziel E, Comeau Y & Villemur R (2001) Initiation of biofilm formation by Pseudomonas aeruginosa 57RP correlates with emergence of hyperpiliated and highly adherent phenotypic variants deficient in swimming, swarming and twitching motilities. J Bacteriol 183: 1195-1204.
    • (2001) J Bacteriol , vol.183 , pp. 1195-1204
    • Déziel, E.1    Comeau, Y.2    Villemur, R.3
  • 13
    • 0037129218 scopus 로고    scopus 로고
    • Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
    • Drenkard E & Ausubel FM (2002) Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature 416: 740-743.
    • (2002) Nature , vol.416 , pp. 740-743
    • Drenkard, E.1    Ausubel, F.M.2
  • 14
    • 0023157690 scopus 로고
    • Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink
    • Elsheikh LE, Kronevi T, Wretlind B, Abaas S & Iglewski BH (1987) Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink. Vet Microbiol 13: 281-289.
    • (1987) Vet Microbiol , vol.13 , pp. 281-289
    • Elsheikh, L.E.1    Kronevi, T.2    Wretlind, B.3    Abaas, S.4    Iglewski, B.H.5
  • 15
    • 0029992026 scopus 로고    scopus 로고
    • Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells
    • Feng G, Tsui HC & Winkler ME (1996) Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells. J Bacteriol 178: 2388-2396.
    • (1996) J Bacteriol , vol.178 , pp. 2388-2396
    • Feng, G.1    Tsui, H.C.2    Winkler, M.E.3
  • 16
    • 0030061698 scopus 로고    scopus 로고
    • Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes
    • Fuqua C & Winans SC (1996) Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes. J Bacteriol 178: 435-440.
    • (1996) J Bacteriol , vol.178 , pp. 435-440
    • Fuqua, C.1    Winans, S.C.2
  • 17
    • 79955366673 scopus 로고    scopus 로고
    • Stationary biofilm growth normalizes mutation frequencies and mutant prevention concentrations in Pseudomonas aeruginosa from cystic fibrosis
    • Garcia-Castillo M, Del Campo R, Baquero F, Morosini MI, Turrientes MC, Zamora J & Cantón R (2011) Stationary biofilm growth normalizes mutation frequencies and mutant prevention concentrations in Pseudomonas aeruginosa from cystic fibrosis. Clin Microbiol Infect 17: 704-711.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 704-711
    • Garcia-Castillo, M.1    Del Campo, R.2    Baquero, F.3    Morosini, M.I.4    Turrientes, M.C.5    Zamora, J.6    Cantón, R.7
  • 18
    • 0029814366 scopus 로고    scopus 로고
    • Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
    • Govan JRW & Deretic V (1996) Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60: 539-574.
    • (1996) Microbiol Rev , vol.60 , pp. 539-574
    • Govan, J.R.W.1    Deretic, V.2
  • 19
    • 0027564440 scopus 로고
    • Elevated exoenzyme expression by Pseudomonas aeruginosa is correlated with exacerbations of lung disease in cystic fibrosis
    • Grimwood K, Semple RA, Rabin HR, Sokol PA & Woods DE (1993) Elevated exoenzyme expression by Pseudomonas aeruginosa is correlated with exacerbations of lung disease in cystic fibrosis. Pediatr Pulmonol 15: 135-139.
    • (1993) Pediatr Pulmonol , vol.15 , pp. 135-139
    • Grimwood, K.1    Semple, R.A.2    Rabin, H.R.3    Sokol, P.A.4    Woods, D.E.5
  • 21
    • 2642572004 scopus 로고    scopus 로고
    • Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa
    • Häußler S (2004) Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa. Environ Microbiol 6: 546-551.
    • (2004) Environ Microbiol , vol.6 , pp. 546-551
    • Häußler, S.1
  • 23
    • 33644865643 scopus 로고    scopus 로고
    • Impact of quorum sensing on fitness of Pseudomonas aeruginosa
    • Heurlier K, Denervaud V & Haas D (2006) Impact of quorum sensing on fitness of Pseudomonas aeruginosa. Int J Med Microbiol 296: 93-102.
    • (2006) Int J Med Microbiol , vol.296 , pp. 93-102
    • Heurlier, K.1    Denervaud, V.2    Haas, D.3
  • 24
    • 67650685860 scopus 로고    scopus 로고
    • Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis
    • Hoboth C, Hoffman LR, Eichner A, Henke C, Schmoldt S, Imhof A, Heesemann J & Hogardt M (2009) Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis. J Infect Dis 200: 118-130.
    • (2009) J Infect Dis , vol.200 , pp. 118-130
    • Hoboth, C.1    Hoffman, L.R.2    Eichner, A.3    Henke, C.4    Schmoldt, S.5    Imhof, A.6    Heesemann, J.7    Hogardt, M.8
  • 26
    • 78549263685 scopus 로고    scopus 로고
    • Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung
    • Hogardt M & Heesemann J (2010) Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung. Int J Med Microbiol 300: 557-562.
    • (2010) Int J Med Microbiol , vol.300 , pp. 557-562
    • Hogardt, M.1    Heesemann, J.2
  • 27
    • 0000271704 scopus 로고
    • Genetic recombinant in Pseudomonas aeruginosa
    • Holloway BW (1955) Genetic recombinant in Pseudomonas aeruginosa. J Gen Microbiol 13: 572-581.
    • (1955) J Gen Microbiol , vol.13 , pp. 572-581
    • Holloway, B.W.1
  • 28
    • 0028934314 scopus 로고
    • Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa
    • Jaffar-Bandjee MC, Lazdunski A, Bally M, Carrere J, Chazalette JP & Galabert C (1995) Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa. J Clin Microbiol 33: 924-929.
    • (1995) J Clin Microbiol , vol.33 , pp. 924-929
    • Jaffar-Bandjee, M.C.1    Lazdunski, A.2    Bally, M.3    Carrere, J.4    Chazalette, J.P.5    Galabert, C.6
  • 30
    • 27744452368 scopus 로고    scopus 로고
    • Clinical significance of seeding dispersal in biofilms
    • Kirov SM, Webb JS & Kjelleberg S (2005) Clinical significance of seeding dispersal in biofilms. Microbiology 151: 3452-3453.
    • (2005) Microbiology , vol.151 , pp. 3452-3453
    • Kirov, S.M.1    Webb, J.S.2    Kjelleberg, S.3
  • 31
    • 35448944740 scopus 로고    scopus 로고
    • Biofilm differentiation and dispersal in mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Kirov SM, Webb JS, O'May CY, Reid DW, Woo J, Rice SA & Kjelleberg S (2007) Biofilm differentiation and dispersal in mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Microbiology 153: 3264-3274.
    • (2007) Microbiology , vol.153 , pp. 3264-3274
    • Kirov, S.M.1    Webb, J.S.2    O'May, C.Y.3    Reid, D.W.4    Woo, J.5    Rice, S.A.6    Kjelleberg, S.7
  • 32
    • 33845959236 scopus 로고    scopus 로고
    • Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypes
    • Koh KS, Lam KW, Alhede M, Queck SY, Labbate M, Kjelleberg S & Rice SA (2007) Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypes. J Bacteriol 189: 119-130.
    • (2007) J Bacteriol , vol.189 , pp. 119-130
    • Koh, K.S.1    Lam, K.W.2    Alhede, M.3    Queck, S.Y.4    Labbate, M.5    Kjelleberg, S.6    Rice, S.A.7
  • 35
    • 15844363824 scopus 로고    scopus 로고
    • Two site-specific recombinases are implicated in phenotypic variation and competitive rhizosphere colonization in Pseudomonas fluorescens
    • Martinez-Granero F, Capdevila S, Sanchez-Contreras M, Martin M & Rivilla R (2005) Two site-specific recombinases are implicated in phenotypic variation and competitive rhizosphere colonization in Pseudomonas fluorescens. Microbiology 151: 975-983.
    • (2005) Microbiology , vol.151 , pp. 975-983
    • Martinez-Granero, F.1    Capdevila, S.2    Sanchez-Contreras, M.3    Martin, M.4    Rivilla, R.5
  • 36
    • 0031467411 scopus 로고    scopus 로고
    • Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
    • McClean KH, Winson MK, Fish L et al. (1997) Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones. Microbiology 143: 3703-3711.
    • (1997) Microbiology , vol.143 , pp. 3703-3711
    • McClean, K.H.1    Winson, M.K.2    Fish, L.3
  • 37
    • 0029659247 scopus 로고    scopus 로고
    • Activity and three-dimensional distribution of toluene-degrading Pseudomonas putida in a multispecies biofilm assessed by quantitative in situ hybridization and scanning confocal laser microscopy
    • Moller S, Pedersen AR, Poulsen LK, Arvin E & Molin S (1996) Activity and three-dimensional distribution of toluene-degrading Pseudomonas putida in a multispecies biofilm assessed by quantitative in situ hybridization and scanning confocal laser microscopy. Appl Environ Microbiol 62: 4632-4640.
    • (1996) Appl Environ Microbiol , vol.62 , pp. 4632-4640
    • Moller, S.1    Pedersen, A.R.2    Poulsen, L.K.3    Arvin, E.4    Molin, S.5
  • 38
    • 0036274037 scopus 로고    scopus 로고
    • The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants
    • Oliver A, Baquero F & Blazquez J (2002) The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants. Mol Microbiol 43: 1641-1650.
    • (2002) Mol Microbiol , vol.43 , pp. 1641-1650
    • Oliver, A.1    Baquero, F.2    Blazquez, J.3
  • 39
    • 33750964700 scopus 로고    scopus 로고
    • Anaerobic culture conditions favor biofilm-like phenotypes in Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • O'May CY, Reid DW & Kirov SM (2006) Anaerobic culture conditions favor biofilm-like phenotypes in Pseudomonas aeruginosa isolates from patients with cystic fibrosis. FEMS Immunol Med Microbiol 48: 373-380.
    • (2006) FEMS Immunol Med Microbiol , vol.48 , pp. 373-380
    • O'May, C.Y.1    Reid, D.W.2    Kirov, S.M.3
  • 40
    • 0031970701 scopus 로고    scopus 로고
    • Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis
    • O'Toole GA & Kolter R (1998) Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis. Mol Microbiol 28: 449-461.
    • (1998) Mol Microbiol , vol.28 , pp. 449-461
    • O'Toole, G.A.1    Kolter, R.2
  • 41
    • 22544455625 scopus 로고    scopus 로고
    • Cystic fibrosis sputum growth and cues key aspects of Pseudomonas aeruginosa physiology
    • Palmer KL, Mashburn LM, Singh PK & Whiteley M (2005) Cystic fibrosis sputum growth and cues key aspects of Pseudomonas aeruginosa physiology. J Bacteriol 187: 5267-5277.
    • (2005) J Bacteriol , vol.187 , pp. 5267-5277
    • Palmer, K.L.1    Mashburn, L.M.2    Singh, P.K.3    Whiteley, M.4
  • 42
    • 36549035760 scopus 로고    scopus 로고
    • Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum
    • Palmer KL, Aye LM & Whiteley M (2007) Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum. J Bacteriol 189: 8079-8087.
    • (2007) J Bacteriol , vol.189 , pp. 8079-8087
    • Palmer, K.L.1    Aye, L.M.2    Whiteley, M.3
  • 43
    • 0031754332 scopus 로고    scopus 로고
    • Genetic analysis of Escherichia coli biofilm formation: roles of flagella, motility, chemotaxis and type I pili
    • Pratt LA & Kolter R (1998) Genetic analysis of Escherichia coli biofilm formation: roles of flagella, motility, chemotaxis and type I pili. Mol Microbiol 30: 295-304.
    • (1998) Mol Microbiol , vol.30 , pp. 295-304
    • Pratt, L.A.1    Kolter, R.2
  • 45
    • 77954645140 scopus 로고    scopus 로고
    • Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts
    • Rau MH, Handsen SK, Johansen HK, Thomsen LE, Workman CT, Nielsen KF, Jelsbak L, Hoiby N, Yang L & Molin S (2010) Early adaptive developments of Pseudomonas aeruginosa after the transition from life in the environment to persistent colonization in the airways of human cystic fibrosis hosts. Environ Microbiol 12: 1643-1658.
    • (2010) Environ Microbiol , vol.12 , pp. 1643-1658
    • Rau, M.H.1    Handsen, S.K.2    Johansen, H.K.3    Thomsen, L.E.4    Workman, C.T.5    Nielsen, K.F.6    Jelsbak, L.7    Hoiby, N.8    Yang, L.9    Molin, S.10
  • 47
    • 0141615605 scopus 로고    scopus 로고
    • The phenotypic consequences of CFTR mutations
    • Rowntree RK & Harris A (2003) The phenotypic consequences of CFTR mutations. Ann Hum Genet 67: 471-485.
    • (2003) Ann Hum Genet , vol.67 , pp. 471-485
    • Rowntree, R.K.1    Harris, A.2
  • 48
    • 0036157549 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm
    • Sauer K, Camper AK, Ehrlich GD, Costerton JW & Davies DG (2002) Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol 184: 1140-1154.
    • (2002) J Bacteriol , vol.184 , pp. 1140-1154
    • Sauer, K.1    Camper, A.K.2    Ehrlich, G.D.3    Costerton, J.W.4    Davies, D.G.5
  • 49
    • 0034641962 scopus 로고    scopus 로고
    • Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
    • Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ & Greenberg EP (2000) Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407: 762-764.
    • (2000) Nature , vol.407 , pp. 762-764
    • Singh, P.K.1    Schaefer, A.L.2    Parsek, M.R.3    Moninger, T.O.4    Welsh, M.J.5    Greenberg, E.P.6
  • 50
    • 33744814106 scopus 로고    scopus 로고
    • Genetic adaptations by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    • Smith EE, Buckley DG, Wu Z et al. (2006a) Genetic adaptations by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. P Natl Acad Sci USA 103: 8487-8492.
    • (2006) P Natl Acad Sci USA , vol.103 , pp. 8487-8492
    • Smith, E.E.1    Buckley, D.G.2    Wu, Z.3
  • 51
    • 33845391544 scopus 로고    scopus 로고
    • Protease IV production in Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis
    • Smith L, Rose B, Tingpej P et al. (2006b) Protease IV production in Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis. J Med Microbiol 55: 1641-1644.
    • (2006) J Med Microbiol , vol.55 , pp. 1641-1644
    • Smith, L.1    Rose, B.2    Tingpej, P.3
  • 52
    • 21244432376 scopus 로고    scopus 로고
    • Microcolony formation: a novel biofilm model of Pseudomonas aeruginosa for the cystic fibrosis lung
    • Sriramulu DD, Lünsdorf H, Lam JS & Römling U (2005) Microcolony formation: a novel biofilm model of Pseudomonas aeruginosa for the cystic fibrosis lung. J Med Microbiol 54: 667-676.
    • (2005) J Med Microbiol , vol.54 , pp. 667-676
    • Sriramulu, D.D.1    Lünsdorf, H.2    Lam, J.S.3    Römling, U.4
  • 53
    • 66149084428 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung
    • Starkey M, Hickman JH, Ma L et al. (2009) Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J Bacteriol 191: 3492-3503.
    • (2009) J Bacteriol , vol.191 , pp. 3492-3503
    • Starkey, M.1    Hickman, J.H.2    Ma, L.3
  • 54
    • 34250630499 scopus 로고    scopus 로고
    • Phenotypic characterization of clonal and nonclonal Pseudomonas aeruginosa strains isolated from lungs of adults with cystic fibrosis
    • Tingpej P, Smith L, Rose B et al. (2007) Phenotypic characterization of clonal and nonclonal Pseudomonas aeruginosa strains isolated from lungs of adults with cystic fibrosis. J Clin Microbiol 45: 1697-1704.
    • (2007) J Clin Microbiol , vol.45 , pp. 1697-1704
    • Tingpej, P.1    Smith, L.2    Rose, B.3
  • 56
    • 9244225159 scopus 로고    scopus 로고
    • Bacteriophage and phenotypic variation in Pseudomonas aeruginosa biofilm formation
    • Webb JS, Lau M & Kjelleberg S (2004) Bacteriophage and phenotypic variation in Pseudomonas aeruginosa biofilm formation. J Bacteriol 186: 8066-8073.
    • (2004) J Bacteriol , vol.186 , pp. 8066-8073
    • Webb, J.S.1    Lau, M.2    Kjelleberg, S.3
  • 58
    • 77957267856 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa: host defence in lung diseases
    • Williams BJ, Dehnbostel J & Blackwell TS (2010) Pseudomonas aeruginosa: host defence in lung diseases. Respirology 15: 1037-1056.
    • (2010) Respirology , vol.15 , pp. 1037-1056
    • Williams, B.J.1    Dehnbostel, J.2    Blackwell, T.S.3
  • 60
    • 0036167851 scopus 로고    scopus 로고
    • Effect of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis
    • Worlitzsch D, Tarran R, Ulrich M et al. (2002) Effect of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis. J Clin Invest 3: 317-325.
    • (2002) J Clin Invest , vol.3 , pp. 317-325
    • Worlitzsch, D.1    Tarran, R.2    Ulrich, M.3


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