Effects of betel nut on cardiovascular risk factors in a rat model

BMC Cardiovascular Disorders

Volumn 12, Issue , 2012, Pages

  Iqbal, Mohammad P ^a   Mehboobali, Naseema ^a   Haider, Ghulam ^a   Pervez, Shahid ^a   Azam, Iqbal ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

Areca nut; Betel nut; Cardiovascular disease; Metabolic syndrome; Rat model

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N ACETYL BETA GLUCOSAMINIDASE; TRIACYLGLYCEROL; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETEL NUT; BODY WEIGHT; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; FOLIC ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERHOMOCYSTEINEMIA; HYPERTRIGLYCERIDEMIA; HYPOCHOLESTEROLEMIA; INFLAMMATORY DISEASE; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL;

ACETYLGLUCOSAMINIDASE; ALANINE TRANSAMINASE; ANIMALS; ARECA; CARDIOVASCULAR DISEASES; CHOLESTEROL, LDL; DISEASE MODELS, ANIMAL; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; RISK FACTORS;

EID: 84867685163     PISSN: None     EISSN: 14712261     Source Type: Journal    
DOI: 10.1186/1471-2261-12-94     Document Type: Article

References (30)

1. Boucher BJ, Mannan N. Metabolic effects of the consumption of Areca catechu. Addict Biol 2002, 7:103-110. 10.1080/13556210120091464, 11900629.
2. Nelson BS, Heischober B. Betel nut: a common drug used by naturalized citizens from India, Far East Asia, and the South Pacific Islands. Ann Emerg Med 1999, 34:238-243. 10.1016/S0196-0644(99)70239-8, 10424931.
3. Ali NS, Khawaja AK. Betel nut (Areca catechu) and its effects on health. Nuts and seeds in health and disease prevention 2011, 197-203. New York: Elsevier Inc, Preedy V, Watson R, Patel V.
4. Yen AM, Chiu YH, Chen LS, Wu HM, Huang CC, Boucher BJ, Chen TH. A population-based study of the association between betel-quid chewing and the metabolic syndrome in men. Am J Clin Nutr 2006, 83(5):1153-1160.
5. Mannan N, Boucher BJ, Evans SJ. Increased waist size and weight in relation to consumption of Areca catechu (betel-nut); a risk factor for increased glycaemia in Asians in east London. Br J Nutr 2000, 83(3):267-275.
6. Yen AM, Chen LS, Chiu YH, Boucher BJ, Chen TH. A prospective community-population-registry based cohort study of the association between betel-quid chewing and cardiovascular disease in men in Taiwan (KCIS no. 19). Am J Clin Nutr 2008, 87(1):70-78.
7. Guh JY, Chen HC, Tsai JF, Chuang LY. Betel-quid use is associated with heart disease in women. Am J Clin Nutr 2007, 85(5):1229-1235.
8. Lin WY, Chiu TY, Lee LT, Lin CC, Huang CY, Huang KC. Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men. Am J Clin Nutr 2008, 87(5):1204-1211.
9. Gamble MV, Ahsan H, Liu X, Factor-Litvak P, Ilievski V, Slavkovich V, Parvez F, Graziano JH. Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh. Am J Clin Nutr 2005, 81(6):1372-1377. 2204145, 15941889.
10. Lin WY, Pi-Sunyer FX, Liu CS, Li TC, Li CI, Huang CY, Lin CC. Betel nut chewing is strongly associated with general and central obesity in Chinese male middle-aged adults. Obesity 2009, 17(6):1247-1254. 2879272, 19247275.
11. Kumar M, Kannan A, Upreti RK. Effect of betel/areca nut (Areca catechu) extracts on intestinal epithelial cell lining. Vet Hum Toxicol 2000, 42(5):257-260.
12. Seals DR, Dinenno FA. Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. Am J Physiol Heart Circ Physiol 2004, 287(5):H1895-H1905. 10.1152/ajpheart.00486.2004, 15475526.
13. Betel Nut http://www.factsandcomparisons.com/assets/FL/RNPBE_websample_monogr.pdf..
14. Saikia M, Vaidehi MP. Studies on the pathological effects of feeding betel-nut meal in albino rats. Br J Exp Path 1983, 64:515-517.
15. Lauren and Heather's blog: about Sprague dawley rats, September 11, 2008 http://laurenheather.wordpress.com/about-Sprague-Dawley-rats/..
16. Wolfensohn S, Lloyd M. Handbook of laboratory animal, management and welfare 2003, Oxford: Blackwell Publishing Ltd, 3.
17. Chanarin I. Laboratory haematology 1989, 130-137. New York: Churchill Livingstone.
18. Quadros EV. Vitamin B12. Modern analytical methodologies in fat and water-soluble vitamins. Chemical analysis series. Volume 154 2000, 311-326. New York: John Wiley, Song WO, Beecher JR, Eitenmiller RR.
19. Rasool S, Abid S, Iqbal MP, Mehboobali N, Haider G, Jafri W. Relationship between vitamin B12, folate and homocysteine levels in H.Pylori infection in patients with functional dyspepsia: a cross-section study. BMC Research Notes 2012, 5:206. 10.1186/1756-0500-5-206, 22546014.
20. Whiting PH, Ross IS, Borthwick L. Serum and urine N-acetyl-beta-D-glucosaminidase in diabetics on diagnosis and subsequent treatment, and stable insulin dependent diabetics. Clin Chim Acta 1979, 92(3):459-463. 10.1016/0009-8981(79)90227-4, 436284.
21. Iqbal MP, Kazmi KA, Jafri HR, Mehboobali N. N-acetyl-β-D-glucosaminidase in acute myocardial infarction. Exp Mol Med 2003, 35:275-278.
22. Gupta PC, Warnakulasuriya S. Global epidemiology of areca nut usage. Addict Biol 2000, 7(1):77-83.
23. Bhopal R. Epidemic of cardiovascular disease in South Asians. Br Med J 2002, 324:625-626.
24. Byun SJ, Kim HS, Jeon SM, Park YB, Choi MS. Supplementation of Areca catechu L. extract alters triglyceride absorption and cholesterol metabolism in rats. Ann Nutr Metab 2001, 45(6):279-284. 10.1159/000046739, 11786651.
25. Park YB, Jeon SM, Byun SJ, Kim HS, Choi MS. Absorption of intestinal free cholesterol is lowered by supplementation of Areca catechu L. extract in rats. Life Sci 2002, 70(16):1849-1859. 10.1016/S0024-3205(02)01485-6, 12005171.
26. Shafique K, Mirza SS, Vart P, Memon AR, Arian MI, Tareen MF, Haq ZU. Areca nut chewing and systemic inflammation: evidence of common pathway for systemic diseases. J Inflamm 2012, 9:22.
27. Iqbal MP. N-acetyl-β-D-glucosaminidase-a marker for a number of inflammatory conditions. Protein structure-function relationship 2006, 93-101. Karachi University: Karachi: International Center for Chemical Sciences, Abbasi A, Ali SA.
28. Tseng CH. Betel nut chewing and incidence of newly diagnosed type 2 diabetes mellitus in Taiwan. BMC Research Notes 2010, 3:228. 10.1186/1756-0500-3-228, 3161372, 20716326.
29. Chiang CP, Chang MC, Lee JJ, Chan JY, Lee PH, Hahn LJ, Jeng JH. Hamsters chewing betal quid or areca nut show a decrease in body weight and survival rates with concomitant epithelial hyperplasia of cheek pouch. Oral Oncol 2004, 40(7):720-727. 10.1016/j.oraloncology.2003.12.015, 15172642.
30. Cesta MF. Normal structure, function and histology of spleen. Toxicol Pathol 2005, 34(5):455-465.