Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users

Breast Cancer Research

Volumn 14, Issue 5, 2012, Pages

  Ellingjord Dale, Merete ^a   Lee, Eunjung ^b   Couto, Elisabeth ^c,d   Ozhand, Ali ^b   Qureshi, Samera A ^a   Hofvind, Solveig ^c,e   Van Den Berg, David J ^b   Akslen, Lars A ^f   Grotmol, Tom ^c   Ursin, Giske ^a,b,c  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CANCER REGISTRY OF NORWAY   (Norway)

^d KAROLINSKA INSTITUTE   (Sweden)

^e OSLO METROPOLITAN UNIVERSITY   (Norway)

^f UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ESTROGEN; GESTAGEN; NORETHISTERONE ACETATE; PROLACTIN; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1A2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; HORMONE; SIGNAL PEPTIDE;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER HORMONE THERAPY; CANCER SCREENING; CROSS-SECTIONAL STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HORMONE METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MAMMOGRAPHIC DENSITY; MAMMOGRAPHY; POSTMENOPAUSE; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; BREAST NEOPLASMS; CAUCASIAN; CONGENITAL MALFORMATION; EARLY DIAGNOSIS; ESTROGEN THERAPY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; MAMMARY GLAND; METABOLISM; MIDDLE AGED; NORWAY; PATHOLOGY;

AGED; ALLELES; BREAST NEOPLASMS; EARLY DETECTION OF CANCER; ESTROGEN REPLACEMENT THERAPY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HORMONES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAMMARY GLANDS, HUMAN; MIDDLE AGED; NORWAY; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE;

EID: 84867674605     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3337     Document Type: Article

References (57)

1. Boyd NF, Martin LJ, Bronskill M, Yaffe MJ, Duric N, Minkin S. Breast tissue composition and susceptibility to breast cancer. J Natl Cancer Inst 2010, 102:1224-1237. 10.1093/jnci/djq239, 2923218, 20616353.
2. Byng JW, Yaffe MJ, Jong RA, Shumak RS, Lockwood GA, Tritchler DL, Boyd NF. Analysis of mammographic density and breast cancer risk from digitized mammograms. Radiographics : a review publication of the Radiological Society of North America, Inc 1998, 18:1587-1598.
3. Guo YP, Martin LJ, Hanna W, Banerjee D, Miller N, Fishell E, Khokha R, Boyd NF. Growth factors and stromal matrix proteins associated with mammographic densities. Cancer Epidemiol Biomarkers Prev 2001, 10:243-248.
4. Hawes D, Downey S, Pearce CL, Bartow S, Wan P, Pike MC, Wu AH. Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity. Breast Cancer Res 2006, 8:R24. 10.1186/bcr1408, 1557710, 16646977.
5. Vachon CM, van Gils CH, Sellers TA, Ghosh K, Pruthi S, Brandt KR, Pankratz VS. Mammographic density, breast cancer risk and risk prediction. Breast Cancer Res 2007, 9:217. 10.1186/bcr1829, 2246184, 18190724.
6. McCormack VA, dos Santos Silva I. Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006, 15:1159-1169. 10.1158/1055-9965.EPI-06-0034, 16775176.
7. Boyd NF, Dite GS, Stone J, Gunasekara A, English DR, McCredie MR, Giles GG, Tritchler D, Chiarelli A, Yaffe MJ, Hopper JL. Heritability of mammographic density, a risk factor for breast cancer. N Engl J Med 2002, 347:886-894. 10.1056/NEJMoa013390, 12239257.
8. Pankow JS, Vachon CM, Kuni CC, King RA, Arnett DK, Grabrick DM, Rich SS, Anderson VE, Sellers TA. Genetic analysis of mammographic breast density in adult women: evidence of a gene effect. J Natl Cancer Inst 1997, 89:549-556. 10.1093/jnci/89.8.549, 9106643.
9. Ursin G, Lillie EO, Lee E, Cockburn M, Schork NJ, Cozen W, Parisky YR, Hamilton AS, Astrahan MA, Mack T. The relative importance of genetics and environment on mammographic density. Cancer Epidemiol Biomarkers Prev 2009, 18:102-112. 10.1158/1055-9965.EPI-07-2857, 19124487.
10. Lee E, Haiman CA, Ma H, Van Den Berg D, Bernstein L, Ursin G. The role of established breast cancer susceptibility loci in mammographic density in young women. Cancer Epidemiol Biomarkers Prev 2008, 171:258-260.
11. Tamimi RM, Cox D, Kraft P, Colditz GA, Hankinson SE, Hunter DJ. Breast cancer susceptibility loci and mammographic density. Breast Cancer Res 2008, 10:R66. 10.1186/bcr2127, 2575539, 18681954.
12. Lindstrom S, Vachon CM, Li J, Varghese J, Thompson D, Warren R, Brown J, Leyland J, Audley T, Wareham NJ, Loos RJ, Paterson AD, Rommens J, Waggott D, Martin LJ, Scott CG, Pankratz VS, Hankinson SE, Hazra A, Hunter DJ, Hopper JL, Southey MC, Chanock SJ, Silva I, Liu J, Eriksson L, Couch FJ, Stone J, Apicella C, Czene K, et al. Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nat Genet 2011, 43:185-187. 10.1038/ng.760, 3076615, 21278746.
13. Greendale GA, Reboussin BA, Slone S, Wasilauskas C, Pike MC, Ursin G. Postmenopausal hormone therapy and change in mammographic density. J Natl Cancer Inst 2003, 95:30-37. 10.1093/jnci/95.1.30, 12509398.
14. McTiernan A, Martin CF, Peck JD, Aragaki AK, Chlebowski RT, Pisano ED, Wang CY, Brunner RL, Johnson KC, Manson JE, Lewis CE, Kotchen JM, Hulka BS, . Women's Health Initiative Mammogram Density Study Investigators Estrogen-plus-progestin use and mammographic density in postmenopausal women: Women's Health Initiative randomized trial. J Natl Cancer Inst 2005, 97:1366-1376. 10.1093/jnci/dji279, 16174858, Women's Health Initiative Mammogram Density Study Investigators.
15. Dite GS, Gurrin LC, Byrnes GB, Stone J, Gunasekara A, McCredie MR, English DR, Giles GG, Cawson J, Hegele RA, Chiarelli AM, Yaffe MJ, Boyd NF, Hopper JL. Predictors of mammographic density: insights gained from a novel regression analysis of a twin study. Cancer Epidemiol Biomarkers Prev 2008, 17:3474-3481. 10.1158/1055-9965.EPI-07-2636, 2677104, 19064564.
16. Butler LM, Gold EB, Greendale GA, Crandall CJ, Modugno F, Oestreicher N, Quesenberry CP, Habel LA. Menstrual and reproductive factors in relation to mammographic density: the Study of Women's Health Across the Nation (SWAN). Breast Cancer Res Treat 2008, 112:165-174. 10.1007/s10549-007-9840-0, 2664291, 18066689.
17. Kelemen LE, Sellers TA, Vachon CM. Can genes for mammographic density inform cancer aetiology?. Nat Rev Cancer 2008, 8:812-823. 10.1038/nrc2466, 2818036, 18772892.
18. Lee E, Ingles SA, Van Den Berg D, Wang W, Lavallee C, Huang MH, Crandall CJ, Stanczyk FZ, Greendale GA, Ursin G. Progestogen levels, progesterone receptor gene polymorphisms, and mammographic density changes: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study. Menopause 2012, 19:302-310. 10.1097/gme.0b013e3182310f9f, 22105149.
19. Haiman CA, Bernstein L, Berg D, Ingles SA, Salane M, Ursin G. Genetic determinants of mammographic density. Breast Cancer Res 2002, 4:R5. 10.1186/bcr434, 111030, 12052257.
20. Haiman CA, Hankinson SE, De Vivo I, Guillemette C, Ishibe N, Hunter DJ, Byrne C. Polymorphisms in steroid hormone pathway genes and mammographic density. Breast Cancer Res Treat 2003, 77:27-36. 10.1023/A:1021112121782, 12602902.
21. Lord SJ, Mack WJ, Van Den Berg D, Pike MC, Ingles SA, Haiman CA, Wang W, Parisky YR, Hodis HN, Ursin G. Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study. Breast Cancer Res 2005, 7:R336-344. 1143576, 15987428.
22. Maskarinec G, Lurie G, Williams AE, Le Marchand L. An investigation of mammographic density and gene variants in healthy women. Int J Cancer 2004, 112:683-688. 10.1002/ijc.20448, 15382051.
23. van Duijnhoven FJ, Bezemer ID, Peeters PH, Roest M, Uitterlinden AG, Grobbee DE, van Gils CH. Polymorphisms in the estrogen receptor alpha gene and mammographic density. Cancer Epidemiol Biomarkers Prev 2005, 14:2655-2660. 10.1158/1055-9965.EPI-05-0398, 16284392.
24. Warren R, Skinner J, Sala E, Denton E, Dowsett M, Folkerd E, Healey CS, Dunning A, Doody D, Ponder B, Luben RN, Day NE, Easton D. Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2006, 15:1502-1508. 10.1158/1055-9965.EPI-05-0828, 16896040.
25. Lillie EO, Bernstein L, Ingles SA, Gauderman WJ, Rivas GE, Gagalang V, Krontiris T, Ursin G. Polymorphism in the androgen receptor and mammographic density in women taking and not taking estrogen and progestin therapy. Cancer Res 2004, 64:1237-1241. 10.1158/0008-5472.CAN-03-2887, 14973115.
26. Chambo D, Kemp C, Costa AM, Souza NC, Guerreiro da Silva ID. Polymorphism in CYP17, GSTM1 and the progesterone receptor genes and its relationship with mammographic density. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas/Sociedade Brasileira de Biofisica [et al] 2009, 42:323-329.
27. Crandall CJ, Sehl ME, Crawford SL, Gold EB, Habel LA, Butler LM, Sowers MR, Greendale GA, Sinsheimer JS. Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. Breast Cancer Res 2009, 11:R51. 10.1186/bcr2340, 2750112, 19630952.
28. Vachon CM, Sellers TA, Carlson EE, Cunningham JM, Hilker CA, Smalley RL, Schaid DJ, Kelemen LE, Couch FJ, Pankratz VS. Strong evidence of a genetic determinant for mammographic density, a major risk factor for breast cancer. Cancer Res 2007, 67:8412-8418. 10.1158/0008-5472.CAN-07-1076, 17804758.
29. Qureshi SA, Couto E, Hilsen M, Hofvind S, Wu AH, Ursin G. Mammographic density and intake of selected nutrients and vitamins in Norwegian women. Nutr Cancer 2011, 63:1011-1020. 10.1080/01635581.2011.605983, 21916704.
30. Qureshi SA, Couto E, Hofvind S, Wu AH, Ursin G. Alcohol intake and mammographic density in postmenopausal Norwegian women. Breast Cancer Res Treat 2012, 131:993-1002. 10.1007/s10549-011-1812-8, 21993860.
31. Couto E, Qureshi SA, Hofvind S, Hilsen M, Aase H, Skaane P, Vatten L, Ursin G. Hormone therapy use and mammographic density in postmenopausal Norwegian women. Breast Cancer Res Treat 2012, 132:297-305. 10.1007/s10549-011-1810-x, 22052325.
32. Hofvind S, Geller B, Vacek PM, Thoresen S, Skaane P. Using the European guidelines to evaluate the Norwegian Breast Cancer Screening Program. Eur J Epidemiol 2007, 22:447-455. 10.1007/s10654-007-9137-y, 17594526.
33. Ursin G, Ma H, Wu AH, Bernstein L, Salane M, Parisky YR, Astrahan M, Siozon CC, Pike MC. Mammographic density and breast cancer in three ethnic groups. Cancer Epidemiol Biomarkers Prev 2003, 12:332-338.
34. Stone J, Ding J, Warren RM, Duffy SW, Hopper JL. Using mammographic density to predict breast cancer risk: dense area or percentage dense area. Breast Cancer Res 2010, 12:R97. 10.1186/bcr2778, 3046440, 21087468.
35. IHMP. , http://www.hapmap.org
36. Edlund CK, Lee WH, Li D, Van Den Berg DJ, Conti DV. Snagger: a user-friendly program for incorporating additional information for tagSNP selection. BMC Bioinformatics 2008, 9:174. 10.1186/1471-2105-9-174, 2375134, 18371222.
37. Fransen L, Muller R, Marmenout A, Tavernier J, Van der Heyden J, Kawashima E, Chollet A, Tizard R, Van Heuverswyn H, Van Vliet A. Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. Nucleic Acids Res 1985, 13:4417-4429. 10.1093/nar/13.12.4417, 321797, 2989794.
38. Kriegler M, Perez C, DeFay K, Albert I, Lu SD. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 1988, 53:45-53. 10.1016/0092-8674(88)90486-2, 3349526.
39. Yang Y, Feng R, Bi S, Xu Y. TNF-alpha polymorphisms and breast cancer. Breast Cancer Res Treat 2011, 129:513-519. 10.1007/s10549-011-1494-2, 21476000.
40. Reeves KW, Weissfeld JL, Modugno F, Diergaarde B. Circulating levels of inflammatory markers and mammographic density among postmenopausal women. Breast Cancer Res Treat 2011, 127:555-563. 10.1007/s10549-010-1249-5, 3431555, 21069450.
41. Dooley TP, Mitchison HM, Munroe PB, Probst P, Neal M, Siciliano MJ, Deng Z, Doggett NA, Callen DF, Gardiner RM. Mapping of two phenol sulphotransferase genes, STP and STM, to 16p: candidate genes for Batten disease. Biochem Biophys Res Commun 1994, 205:482-489. 10.1006/bbrc.1994.2691, 7999068.
42. Dumas I, Diorio C. Estrogen pathway polymorphisms and mammographic density. Anticancer research 2011, 31:4369-4386.
43. Yong M, Schwartz SM, Atkinson C, Makar KW, Thomas SS, Stanczyk FZ, Westerlind KC, Newton KM, Holt VL, Leisenring WM, Lampe JW. Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States. The J Steroid Biochem Mol Biol 2011, 124:10-18.
44. Mitrunen K, Hirvonen A. Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. Mutat Res 2003, 544:9-41. 10.1016/S1383-5742(03)00016-4, 12888106.
45. Zhao YN, Zhang W, Chen YC, Fang F, Liu XQ. Relative imbalances in the expression of catechol-O-methyltransferase and cytochrome P450 in breast cancer tissue and their association with breast carcinoma. Maturitas 2012, 72:139-145. 10.1016/j.maturitas.2012.03.003, 22464883.
46. Reding KW, Weiss NS, Chen C, Li CI, Carlson CS, Wilkerson HW, Farin FM, Thummel KE, Daling JR, Malone KE. Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2009, 18:1461-1467. 10.1158/1055-9965.EPI-08-0917, 2764317, 19383894.
47. Evans AM, Petersen JW, Sekhon GS, DeMars R. Mapping of prolactin and tumor necrosis factor-beta genes on human chromosome 6p using lymphoblastoid cell deletion mutants. Somat Cell Mol Genet 1989, 15:203-213. 10.1007/BF01534871, 2567059.
48. Bachelot A, Binart N. Reproductive role of prolactin. Reproduction 2007, 133:361-369. 10.1530/REP-06-0299, 17307904.
49. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. The role of prolactin in mammary carcinoma. Endocr Rev 2003, 24:1-27. 10.1210/er.2001-0036, 1698952, 12588805.
50. Touraine P, Martini JF, Zafrani B, Durand JC, Labaille F, Malet C, Nicolas A, Trivin C, Postel-Vinay MC, Kuttenn F, Kelly PA. Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues. J Clin Endocrinol Metab 1998, 83:667-674. 10.1210/jc.83.2.667, 9467590.
51. Ginsburg E, Vonderhaar BK. Prolactin synthesis and secretion by human breast cancer cells. Cancer Res 1995, 55:2591-2595.
52. Gill S, Peston D, Vonderhaar BK, Shousha S. Expression of prolactin receptors in normal, benign, and malignant breast tissue: an immunohistological study. J Clin Pathol 2001, 54:956-960. 10.1136/jcp.54.12.956, 1731342, 11729217.
53. Perks CM, Keith AJ, Goodhew KL, Savage PB, Winters ZE, Holly JM. Prolactin acts as a potent survival factor for human breast cancer cell lines. Br J Cancer 2004, 91:305-311. 2409804, 15213724.
54. Nyante SJ, Faupel-Badger JM, Sherman ME, Pfeiffer RM, Gaudet MM, Falk RT, Andaya AA, Lissowska J, Brinton LA, Peplonska B, Vonderhaar BK, Chanock S, Garcia-Closas M, Figueroa JD. Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case-control study in Poland. Breast Cancer Res 2011, 13:R42. 10.1186/bcr2864, 3219205, 21470416.
55. Ma H, Henderson KD, Sullivan-Halley J, Duan L, Marshall SF, Ursin G, Horn-Ross PL, Largent J, Deapen DM, Lacey JV, Bernstein L. Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res 2010, 12:R35. 10.1186/bcr2589, 2917030, 20565829.
56. Hankinson SE, Willett WC, Michaud DS, Manson JE, Colditz GA, Longcope C, Rosner B, Speizer FE. Plasma prolactin levels and subsequent risk of breast cancer in postmenopausal women. J Natl Cancer Inst 1999, 91:629-634. 10.1093/jnci/91.7.629, 10203283.
57. Kalleinen N, Polo-Kantola P, Irjala K, Porkka-Heiskanen T, Vahlberg T, Virkki A, Polo O. 24-hour serum levels of growth hormone, prolactin, and cortisol in pre- and postmenopausal women: the effect of combined estrogen and progestin treatment. J Clin Endocrinol Metab 2008, 93:1655-1661. 10.1210/jc.2007-2677, 18319308.