Children With Autism Show Reduced Somatosensory Response: An MEG Study

Autism Research

Volumn 5, Issue 5, 2012, Pages 340-351

  Marco, Elysa J ^a   Khatibi, Kasra ^a   Hill, Susanna S ^a   Siegel, Bryna ^b   Arroyo, Monica S ^b   Dowling, Anne F ^a   Neuhaus, John M ^a   Sherr, Elliott H ^c   Hinkley, Leighton N B ^a   Nagarajan, Srikantan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cognitive neuroscience; Event related potential; Low level perception; Magnetoencephalography; School age

Indexed keywords

AMPLITUDE MODULATION; ARTICLE; AUTISM; CHILD; CHILD BEHAVIOR; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EVOKED SOMATOSENSORY RESPONSE; FINGER; HUMAN; LEFT HANDEDNESS; LEFT HEMISPHERE; MAGNETOENCEPHALOGRAPHY; MALE; PARENT; PATHOPHYSIOLOGY; PHALANX; POST HOC ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RIGHT HANDEDNESS; RIGHT HEMISPHERE; SCHOOL CHILD; SENSORY ANALYSIS; SENSORY PROFILE QUESTIONNAIRE; SOMATOSENSORY CORTEX; STIMULUS; TACTILE STIMULATION;

AUTISTIC DISORDER; CASE-CONTROL STUDIES; CHILD; EVOKED POTENTIALS, SOMATOSENSORY; HUMANS; LINEAR MODELS; MAGNETOENCEPHALOGRAPHY; MALE; PROSPECTIVE STUDIES; SOMATOSENSORY CORTEX; TOUCH PERCEPTION;

EID: 84867663116     PISSN: 19393792     EISSN: 19393806     Source Type: Journal    
DOI: 10.1002/aur.1247     Document Type: Article

References (39)

1. Akatsuka, K., Wasaka, T., Nakata, H., Kida, T., Hoshiyama, M., etal. (2007). Objective examination for two-point stimulation using a somatosensory oddball paradigm: An MEG study. Clinical Neurophysiology, 118, 403-411. doi: S1388-2457(06)01475-1 [pii] 10.1016/j.clinph.2006.09.030
2. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.
3. Asperger, H. (1944). [Autistic psychopathy of childhood]. Archiv für Psychiatrie und Nervenkrankheiten, 117, 76-136.
4. Bader, P.L., Faizi, M., Kim, L.H., Owen, S.F., Tadross, M.R., etal. (2011). Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proceedings of the National Academy of Sciences of the United States of America, 108, 15432-15437. doi: 1112667108 [pii] 10.1073/pnas.1112667108
5. Baranek, G.T., David, F.J., Poe, M.D., Stone, W.L., & Watson, L.R. (2006). Sensory Experiences Questionnaire: Discriminating sensory features in young children with autism, developmental delays, and typical development. Journal of Child Psychology and Psychiatry, 47, 591-601. doi: JCPP1546 [pii] 10.1111/j.1469-7610.2005.01546.x
6. Ben-Sasson, A., Hen, L., Fluss, R., Cermak, S.A., Engel-Yeger, B., & Gal, E. (2009). A meta-analysis of sensory modulation symptoms in individuals with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 1-11. doi: 10.1007/s10803-008-0593-3
7. Blakemore, S.J., Tavassoli, T., Calo, S., Thomas, R.M., Catmur, C., etal. (2006). Tactile sensitivity in Asperger syndrome. Brain and Cognition, 61, 5-13. doi: S0278-2626(05)00184-3 [pii] 10.1016/j.bandc.2005.12.013
8. Casanova, M.F., Buxhoeveden, D., & Gomez, J. (2003). Disruption in the inhibitory architecture of the cell minicolumn: Implications for autism. Neuroscientist, 9, 496-507.
9. Casanova, M.F., Buxhoeveden, D.P., & Brown, C. (2002). Clinical and macroscopic correlates of minicolumnar pathology in autism. Journal of Child Neurology, 17, 692-695.
10. Cascio, C., McGlone, F., Folger, S., Tannan, V., Baranek, G., etal. (2008). Tactile perception in adults with autism: A multidimensional psychophysical study. Journal of Autism and Developmental Disorders, 38, 127-137. doi: 10.1007/s10803-007-0370-8
11. Coskun, M.A., Varghese, L., Reddoch, S., Castillo, E.M., Pearson, D.A., etal. (2009). How somatic cortical maps differ in autistic and typical brains. Neuroreport, 20, 175-179. doi: 10.1097/WNR.0b013e32831f47d1
12. Dane, S., & Balci, N. (2007). Handedness, eyedness and nasal cycle in children with autism. International Journal of Developmental Neuroscience, 25, 223-226. doi:S0736-5748(07)00042-1 [pii] 10.1016/j.ijdevneu.2007.03.005
13. Daw, M.I., Ashby, M.C., & Isaac, J.T. (2007). Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex. Nature Neuroscience, 10, 453-461. doi:nn1866 [pii] 10.1038/nn1866
14. DeLorey, T.M., Sahbaie, P., Hashemi, E., Li, W.W., Salehi, A., & Clark, D.J. (2010). Somatosensory and sensorimotor consequences associated with the heterozygous disruption of the autism candidate gene, Gabrb3. Behavioural Brain Research, 216, 36-45. doi: S0166-4328(10)00476-6 [pii] 10.1016/j.bbr.2010.06.032
15. Dunn, W., & Westman, K. (1997). The sensory profile: The performance of a national sample of children without disabilities. American Journal of Occupational Therapy, 51, 25-34.
16. Durand, C.M., Betancur, C., Boeckers, T.M., Bockmann, J., Chaste, P., etal. (2007). Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics, 39, 25-27. doi: ng1933 [pii] 10.1038/ng1933
17. Etherton, M., Foldy, C., Sharma, M., Tabuchi, K., Liu, X., etal. (2010). Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proceedings of the National Academy of Sciences of the United States of America, 108, 13764-13769. doi: 1111093108 [pii] 10.1073/pnas.1111093108
18. Fatemi, S.H., Reutiman, T.J., Folsom, T.D., & Thuras, P.D. (2009). GABA(A) receptor downregulation in brains of subjects with autism. Journal of Autism and Developmental Disorders, 39, 223-230. doi: 10.1007/s10803-008-0646-7
19. Guclu, B., Tanidir, C., Mukaddes, N.M., & Unal, F. (2007). Tactile sensitivity of normal and autistic children. Somatosensory and Motor Research, 24, 21-33. doi:779333922 [pii] 10.1080/08990220601179418
20. Hashimoto, T., Tayama, M., & Miyao, M. (1986). Short latency somatosensory evoked potentials in children with autism. Brain and Development, 8, 428-432.
21. Hull, C., & Scanziani, M. (2007). It's about time for thalamocortical circuits. Nature Neuroscience, 10, 400-402. doi: nn0407-400 [pii] 10.1038/nn0407-400
22. Kemner, C., Verbaten, M.N., Cuperus, J.M., Camfferman, G., & Van Engeland, H. (1994). Visual and somatosensory event-related brain potentials in autistic children and three different control groups. Electroencephalography and Clinical Neurophysiology, 92, 225-237.
23. Leekam, S.R., Nieto, C., Libby, S.J., Wing, L., & Gould, J. (2007). Describing the sensory abnormalities of children and adults with autism. Journal of Autism and Developmental Disorders, 37, 894-910. doi: 10.1007/s10803-006-0218-7
24. Marco, E.J., Hinkley, L.B., Hill, S.S., & Nagarajan, S.S. (2011). Sensory processing in autism: A review of neurophysiologic findings. Pediatric Research, 69, 48R-54R. doi:10.1203/PDR.0b013e3182130c54
25. McCulloch, C.E., Searle, S.R., & Neuhaus, J.M. (2008). Generalized, linear, and mixed models, 2nd ed. Hoboken, NJ: Wiley.
26. Miyazaki, M., Fujii, E., Saijo, T., Mori, K., Hashimoto, T., etal. (2007). Short-latency somatosensory evoked potentials in infantile autism: Evidence of hyperactivity in the right primary somatosensory area. Developmental Medicine and Child Neurology, 49, 13-17. doi: DMCN0059a [pii] 10.1111/j.1469-8749.2007.0059a.x
27. Redcay, E., & Courchesne, E. (2008). Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder. Biological Psychiatry, 64, 589-598. doi: S0006-3223(08)00667-7 [pii] 10.1016/j.biopsych.2008.05.020
28. Restuccia, D., Zanini, S., Cazzagon, M., Del Piero, I., Martucci, L., & Della Marca, G. (2009). Somatosensory mismatch negativity in healthy children. Developmental Medicine and Child Neurology, 51, 991-998. doi:DMCN3367 [pii] 10.1111/j.1469-8749.2009.03367.x
29. Rubenstein, J.L., & Merzenich, M.M. (2003). Model of autism: Increased ratio of excitation/inhibition in key neural systems. Genes, Brain, and Behavior, 2, 255-267.
30. Russo, N., Foxe, J.J., Brandwein, A.B., Altschuler, T., Gomes, H., & Molholm, S. (2010). Multisensory processing in children with autism: High-density electrical mapping of auditory-somatosensory integration. Autism Res, 3, 253-267. doi: 10.1002/aur.152
31. Rutter, M., Bailey, A., & Lord, C. (2003). Social communication questionnaire manual. Los Angeles: Western Psychological Services.
32. Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., etal. (2007). Strong association of de novo copy number mutations with autism. Science, 316, 445-449. doi: 1138659 [pii] 10.1126/science.1138659.
33. Sokhadze, E., Baruth, J., Tasman, A., Sears, L., Mathai, G., etal. (2009). Event-related potential study of novelty processing abnormalities in autism. Applied Psychophysiology and Biofeedback, 34, 37-51. doi: 10.1007/s10484-009-9074-5
34. Splawski, I., Timothy, K.W., Sharpe, L.M., Decher, N., Kumar, P., etal. (2004). Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell, 119, 19-31. doi: 10.1016/j.cell.2004.09.011 S0092867404008426 [pii]
35. Szatmari, P., Paterson, A.D., Zwaigenbaum, L., Roberts, W., Brian, J., etal. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39, 319-328. doi: ng1985 [pii] 10.1038/ng1985
36. Tomchek, S.D., & Dunn, W. (2007). Sensory processing in children with and without autism: A comparative study using the short sensory profile. American Journal of Occupational Therapy, 61, 190-200.
37. Wechsler, D. (1991). The Wechsler intelligence scale for children, 3rd ed. San Antonio: Psychological Corporation.
38. Wikstrom, H., Huttunen, J., Korvenoja, A., Virtanen, J., Salonen, O., etal. (1996). Effects of interstimulus interval on somatosensory evoked magnetic fields (SEFs): A hypothesis concerning SEF generation at the primary sensorimotor cortex. Electroencephalography and Clinical Neurophysiology, 100, 479-487.
39. Zhu, Z., Disbrow, E.A., Zumer, J.M., McGonigle, D.J., & Nagarajan, S.S. (2007). Spatiotemporal integration of tactile information in human somatosensory cortex. BMC Neuroscience, 8, 21-35. doi:1471-2202-8-21 [pii] 10.1186/1471-2202-8-21