Tacrolimus (FK506) prevents early retinal neovascularization in streptozotocin-induced diabetic mice

International Immunopharmacology

Volumn 14, Issue 4, 2012, Pages 606-612

  Su, Landi ^a,b   Ji, Jing ^b   Bian, Jieyu ^b   Fu, Yuxuan ^b   Ge, Yingbin ^b   Yuan, Zhilan ^b  

^a Yangzhou Vocational College of Environment and Resources   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes; Inflammation; Mouse; Retina; Tacrolimus

Indexed keywords

BIOLOGICAL MARKER; CYCLOOXYGENASE 2; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; STREPTOZOCIN; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETIC RETINOPATHY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVATION; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA; RETINA NEOVASCULARIZATION; STREPTOZOCIN DIABETES; TREATMENT DURATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; GENE EXPRESSION REGULATION; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; RANDOM ALLOCATION; RETINA; TACROLIMUS;

EID: 84867653410     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.09.010     Document Type: Article

References (32)

1. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053
2. P.J. Watkins ABC of diabetes-retinopathy BMJ 326 2003 924 926
3. C. Murdoch, M. Muthana, and C.E. Lewis Hypoxia regulates macrophage functions in inflammation J Immunol 175 2005 6257 6263
4. J. Tang, and T.S. Kern Inflammation in diabetic retinopathy Prog Retin Eye Res 30 2011 343 358
5. A.P. Adamis, and A.J. Berman Immunological mechanisms in the pathogenesis of diabetic retinopathy Semin Immunopathol 30 2008 65 84
6. A.M. Joussen, V. Poulaki, M.L. Le, K. Koizumi, C. Esser, and H. Janicki A central role for inflammation in the pathogenesis of diabetic retinopathy FASEB J 18 2004 1450 1452
7. A.P. Adamis, L.P. Aiello, and R.A. D'Amato Angiogenesis and ophthalmic disease Angiogenesis 3 1999 9 14
8. S. Ishida, T. Usui, K. Yamashiro, Y. Kaji, S. Amano, and Y. Ogura VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization J Exp Med 198 2003 483 489
9. N. Nagai, K. Izumi-Nagai, Y. Oike, T. Koto, S. Satofuka, and Y. Ozawa Suppression of diabetes-induced retinal in flammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway Invest Ophthalmol Vis Sci 48 2007 4342 4350
10. S. Todo, J.J. Fung, T.E. Starzl, A. Tzakis, A.J. Demetris, and R. Kormos Liver, kidney, and thoracic organ transplantation under FK 506 Ann Surg 212 1990 295 305 [discussion 306-7]
11. D.C. Baumgart, J.P. Pintoffl, A. Sturm, B. Wiedenmann, and A.U. Dignass Tacrolimus is safe and effective in patients with severe steroid-refractory or steroid-dependent inflammatory bowel disease - a long-term follow-up Am J Gastroenterol 101 2006 1048 1056
12. K. Thestrup-Pedersen Tacrolimus treatment of atopic eczema/dermatitis syndrome Curr Opin Allergy Clin Immunol 3 2003 359 362
13. M. Zeyda, R. Geyeregger, M. Poglitsch, T. Weichhart, G.J. Zlabinger, and S. Koyasu Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation J Leukoc Biol 81 2007 319 327
14. S. Du, N. Hiramatsu, K. Hayakawa, A. Kasai, M. Okamura, and T. Huang Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response J Immunol 182 2009 7201 7211
15. T. Yoshino, H. Nakase, Y. Honzawa, K. Matsumura, S. Yamamoto, and Y. Takeda Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis Inflamm Bowel Dis 16 2010 2022 2033
16. T. Nakamura-Yanagidaira, Y. Takahashi, K. Sano, T. Murata, and T. Hayashi Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation Mol Vis 17 2011 2157 2170
17. N.K. Sharma, T.A. Gardiner, and D.B. Archer A morphologic and autoradiographic study of cell death and regeneration in the retinal microvasculature of normal and diabetic rats Am J Ophthalmol 100 1985 51 60
18. M. Mizutani, T.S. Kern, and M. Lorenzi Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy J Clin Invest 97 1996 2883 2890
19. K. Oh-i, H. Keino, H. Goto, N. Yamakawa, K. Murase, and Y. Usui Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in rats Br J Ophthalmol 91 2007 237 242
20. A. Spierer, R. Rabinowitz, S. Pri-Chen, and M. Rosner An increase in superoxide dismutase ameliorates oxygen-induced retinopathy Eye (Lond) 19 2005 86 91
21. A. Otani, M.I. Dorrell, K. Kinder, S.K. Moreno, S. Nusinowitz, and E. Banin Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells J Clin Invest 114 2004 765 774
22. M.E. Jockovich, Y. Piña, A. Alegret, C. Cebulla, W. Feuer, and T.G. Murray Heterogeneous tumor vasculature in retinoblastoma: implications for vessel targeting therapy Retina 28 2008 S81 S86
23. G.Y. Tsai, J.Z. Cui, H. Syed, Z. Xia, U. Ozerdem, and J.H. McNeill Effect of N-acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats Clin Experiment Ophthalmol 37 2009 223 231
24. W.J. Schnedl, S. Ferber, J.H. Johnson, and C.B. Newgard STZ transport and cytotoxicity: specific enhancement in GLUT2-expressing cells Diabetes 43 1994 1326 1333
25. S. Satofuka, A. Ichihara, N. Nagai, K. Noda, Y. Ozawa, and A. Fukamizu (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation Diabetes 58 2009 1625 1633
26. J.A. Brockman, D.C. Scherer, T.A. McKinsey, S.M. Hall, X. Qi, and W.Y. Lee Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation Mol Cell Biol 15 1995 2809 2818
27. K. Brown, S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation Science 267 1995 1485 1488
28. J. DiDonato, F. Mercurio, C. Rosette, J. Wu-Li, H. Suyang, and S. Ghosh Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation Mol Cell Biol 16 1996 1295 1304
29. A.S. Baldwin Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights Annu Rev Immunol 14 1996 649 683
30. A. Yoshida, S. Yoshida, T. Ishibashi, M. Kuwano, and H. Inomata Suppression of retinal neovascularization by the NF-kappaB inhibitor pyrrolidine dithiocarbamate in mice Invest Ophthalmol Vis Sci 40 1999 1624 1629
31. J.K. Krady, A. Basu, C.M. Allen, Y. Xu, K.F. LaNoue, and T.W. Gardner Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy Diabetes 54 2005 1559 1565
32. J. Wang, S. Jiang, J.M. Kwong, R.N. Sanchez, A.A. Sadun, and T.T. Lam Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats Brain Res 1081 2006 211 218