Chromosomal aberrations by 4-color fluorescence in situ hybridization not detected in spitz nevi of older individuals

Archives of Dermatology

Volumn 148, Issue 10, 2012, Pages 1152-1156

  Horst, Basil A ^a   Fang, Yuqiang ^b   Silvers, David N ^a   Busam, Klaus J ^b  

^a Department of Medicine   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; JUVENILE MELANOMA; KARYOTYPE; MALE; MELANOCYTIC NEVUS; POLYPLOIDY; PRIORITY JOURNAL; SKIN DEFECT; SKIN EXAMINATION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CHILD; CHROMOSOME ABERRATIONS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPE; MALE; MIDDLE AGED; NEVUS, EPITHELIOID AND SPINDLE CELL; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SKIN NEOPLASMS;

EID: 84867651846     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archdermatol.2012.2267     Document Type: Article

References (19)

1. Balaban G, Herlyn M, Guerry D IV, et al. Cytogenetics of human malignant melanoma and premalignant lesions. Cancer Genet Cytogenet. 1984;11(4):429-439. (Pubitemid 14107795)
2. Bastian BC, Olshen AB, LeBoit PE, Pinkel D. Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003;163(5):1765-1770. (Pubitemid 37310008)
3. Gerami P, Jewell SS, Morrison LE, et al. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009;33(8):1146-1156.
4. Spitz S. Melanomas of childhood. Am J Pathol. 1948;24(3):591-609.
5. Dal Pozzo V, Benelli C, Restano L, Gianotti R, Cesana BM. Clinical review of 247 case records of Spitz nevus (epithelioid cell and/or spindle cell nevus). Dermatology. 1997;194(1):20-25. (Pubitemid 27047327)
6. Barnhill RL. The Spitzoid lesion: rethinking Spitz tumors, atypical variants, "Spitzoid melanoma" and risk assessment. Mod Pathol. 2006;19(suppl 2):S21-S33. (Pubitemid 43172307)
7. Isaac AK, Lertsburapa T, Pathria Mundi J, Martini M, Guitart J, Gerami P. Polyploidy in Spitz nevi: a not uncommon karyotypic abnormality identifiable by fluorescence in situ hybridization. Am J Dermatopathol. 2010;32(2):144-148.
8. Bastian BC, Wesselmann U, Pinkel D, Leboit PE. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113(6):1065-1069. (Pubitemid 30013354)
9. Zedek DC, McCalmont TH. Spitz nevi, atypical spitzoid neoplasms, and spitzoid melanoma. Clin Lab Med. 2011;31(2):311-320.
10. Gerami P, Wass A, Mafee M, Fang Y, Pulitzer MP, Busam KJ. Fluorescence in situ hybridization for distinguishing nevoid melanomas from mitotically active nevi. Am J Surg Pathol. 2009;33(12):1783-1788.
11. Cesinaro AM, Foroni M, Sighinolfi P, Migaldi M, Trentini GP. Spitz nevus is relatively frequent in adults: a clinico-pathologic study of 247 cases related to patient's age. Am J Dermatopathol. 2005;27(6):469-475. (Pubitemid 44383989)
12. Requena C, Requena L, Kutzner H, Sánchez Yus E. Spitz nevus: a clinicopathological study of 349 cases. Am J Dermatopathol. 2009;31(2):107-116.
13. McKee PECE, Granter SR. Melanocytic nevi. In: McKee PE, Calonje E, Granter SR, eds. Pathology of the Skin With Clinical Correlations. 3rd ed. Philadelphia, PA: Mosby; 2005:1268.
14. Boone SL, Busam KJ, Marghoob AA, et al. Two cases of multiple Spitz nevi: correlating clinical, histologic, and fluorescence in situ hybridization findings. Arch Dermatol. 2011;147(2):227-231.
15. Pennacchia I, Gasbarra R, Manente L, et al. Polypoid Spitz nevus: two cases evaluated with genetic technique, prolonged follow up, and sentinel lymph node biopsy. J Cutan Pathol. 2011;38(9):747-752.
16. Gerami P, Beilfuss B, Haghighat Z, Fang Y, Jhanwar S, Busam KJ. Fluorescence in situ hybridization as an ancillary method for the distinction of desmoplastic melanomas from sclerosing melanocytic nevi. J Cutan Pathol . 2011;38(4):329-334.
17. Barnhill RL, Argenyi ZB, From L, et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol. 1999;30(5):513-520. (Pubitemid 29218042)
18. Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol. 2000;157(3):967-972. (Pubitemid 32109388)
19. Gammon B, Beilfuss B, Guitart J, Gerami P. Enhanced detection of spitzoid melanomas using fluorescence in situ hybridization with 9p21 as an adjunctive probe. Am J Surg Pathol. 2012;36(1):81-88.