Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 42, 2012, Pages 16864-16869

  Maestre Reyna, Manuel ^a   Diderrich, Rike ^a   Veelders, Maik Stefan ^a   Eulenburg, Georg ^a   Kalugin, Vitali ^a   Bruc̈kner, Stefan ^a   Keller, Petra ^b   Rupp, Steffen ^b   Mos̈ch, Hans Ulrich ^a   Essen, Lars Oliver ^a,c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Fungal pathogen; Lectin; Molecular recognition; T antigen

Indexed keywords

CARBOHYDRATE; EPA1A PROTEIN; FUNGAL PROTEIN; GLYCAN; MUCIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM BINDING; CANDIDA GLABRATA; CANDIDIASIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; EPITHELIUM; FUNGAL COLONIZATION; HOST; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE;

CALCIUM; CANDIDA GLABRATA; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE; FUNGAL PROTEINS; LECTINS; MODELS, MOLECULAR; MULTIGENE FAMILY; PHYLOGENY; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84867646292     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207653109     Document Type: Article

References (28)

1. Kaur R, Domergue R, Zupancic ML, Cormack BP (2005) A yeast by any other name: Candida glabrata and its interaction with the host. Curr Opin Microbiol 8:378-384. (Pubitemid 41021896)
2. Gulia J, Aryal S, Saadlla H, Shorr AF (2010) Healthcare-associated candidemia-a distinct entity? J Hosp Med 5:298-301.
3. Komshian SV, Uwaydah AK, Sobel JD, Crane LR (1989) Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: Frequency, characteristics, and evaluation of factors influencing outcome. Rev Infect Dis 11:379-390.
4. Buitrón García-Figueroa R, Araiza-Santibáñez J, Basurto-Kuba E, Bonifaz-Trujillo A (2009) Candida glabrata: An emergent opportunist in vulvovaginitis. Cir Cir 77:423-427.
5. Pignato S, et al. (2009) Persistent oral and urinary Candida spp. carriage in Italian HIV-seropositive asymptomatic subjects. J Prev Med Hyg 50:232-235.
6. Mundy RD, Cormack B (2009) Expression of Candida glabrata adhesins after exposure to chemical preservatives. J Infect Dis 199:1891-1898.
7. Cormack BP, Ghori N, Falkow S (1999) An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 285:578-582.
8. Filler SG (2006) Candida-host cell receptor-ligand interactions. Curr Opin Microbiol 9:333-339.
9. Castaño I, et al. (2005) Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata. Mol Microbiol 55:1246-1258. (Pubitemid 40299191)
10. Linder T, Gustafsson CM (2008) Molecular phylogenetics of ascomycotal adhesins-a novel family of putative cell-surface adhesive proteins in fission yeasts. Fungal Genet Biol 45:485-497. (Pubitemid 351308111)
11. Verstrepen KJ, Reynolds TB, Fink GR (2004) Origins of variation in the fungal cell surface. Nat Rev Microbiol 2:533-540. (Pubitemid 39200029)
12. Veelders M, et al. (2010) Structural basis of flocculin-mediated social behavior in yeast. Proc Natl Acad Sci USA 107:22511-22516.
13. Rigden DJ, Mello LV, Galperin MY (2004) The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules. Trends Biochem Sci 29:335-339. (Pubitemid 38968748)
14. Ielasi FS, Decanniere K, Willaert RG (2012) The epithelial adhesin 1 (Epa1p) from the human-pathogenic yeast Candida glabrata: Structural and functional study of the carbohydrate-binding domain. Acta Crystallogr D Biol Crystallogr 68:210-217.
15. Zupancic ML, et al. (2008) Glycan microarray analysis of Candida glabrata adhesin ligand specificity. Mol Microbiol 68:547-559. (Pubitemid 351490190)
16. Petosa C, Collier RJ, Klimpel KR, Leppla SH, Liddington RC (1997) Crystal structure of the anthrax toxin protective antigen. Nature 385:833-838. (Pubitemid 27106075)
17. Ramage G, Mowat E, Jones B, Williams C, Lopez-Ribot J (2009) Our current understanding of fungal biofilms. Crit Rev Microbiol 35:340-355.
18. Iraqui I, et al. (2005) The Yak1p kinase controls expression of adhesins and biofilm formation in Candida glabrata in a Sir4p-dependent pathway. Mol Microbiol 55:1259-1271. (Pubitemid 40299192)
19. Domergue R, et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI. Science 308:866-870. (Pubitemid 40629269)
20. Nieuw Amerongen AV, Bolscher JG, Bloemena E, Veerman EC (1998) Sulfomucins in the human body. Biol Chem 379:1-18. (Pubitemid 28052389)
21. McEntyre J, et al. (2009) Essentials of Glycobiology. Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), 2nd Ed.
22. Linden SK, Sutton P, Karlsson NG, Korolik V, McGuckin MA (2008) Mucins in the mucosal barrier to infection. Mucosal Immunol 1:183-197. (Pubitemid 351541304)
23. Arendrup MC (2010) Epidemiology of invasive candidiasis. Curr Opin Crit Care 16:445-452.
24. Larkin MA, et al. (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23:2947-2948. (Pubitemid 350162903)
25. Papadopoulos JS, Agarwala R (2007) COBALT: Constraint-based alignment tool for multiple protein sequences. Bioinformatics 23:1073-1079. (Pubitemid 47050558)
26. Notredame C, Higgins DG, Heringa J (2000) T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol 302:205-217.
27. O'Sullivan O, Suhre K, Abergel C, Higgins DG, Notredame C (2004) 3DCoffee: Combining protein sequences and structures within multiple sequence alignments. J Mol Biol 340:385-395. (Pubitemid 38759917)
28. Dieterich C, et al. (2002) In vitro reconstructed human epithelia reveal contributions of Candida albicans EFG1 and CPH1 to adhesion and invasion. Microbiology 148:497-506. (Pubitemid 34162792)