Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells

Biochemical and Biophysical Research Communications

Volumn 427, Issue 1, 2012, Pages 91-95

  Kappe, Camilla ^a   Holst, Jens J ^b   Zhang, Qimin ^a   Sjöholm, åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Glucagon like peptide 1; L cell; Lipotoxicity; Metformin

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; GLUCAGON LIKE PEPTIDE 1; METFORMIN; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IN VITRO STUDY; LIPOTOXICITY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CELL LINE; CHROMANS; CYTOPROTECTION; FATTY ACIDS, NONESTERIFIED; GLUCAGON-LIKE PEPTIDE 1; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; MAP KINASE KINASE 3; MAP KINASE KINASE 4; MAP KINASE KINASE 6; METFORMIN; MICE; MICE, TRANSGENIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITATES; REACTIVE OXYGEN SPECIES;

MURINAE;

EID: 84867643750     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.09.010     Document Type: Article

References (20)

1. Meetoo D., McGovern P., Safadi R. An epidemiological overview of diabetes across the world. Br. J. Nurs. 2007, 16:1002-1007.
2. Drucker D.J. The role of gut hormones in glucose homeostasis. J. Clin. Invest. 2007, 117:24-32.
3. Meier J.J., Nauck M.A. Glucagon-like peptide 1(GLP-1) in biology and pathology. Diabetes Metab. Res. Rev. 2005, 21:91-117.
4. Vilsboll T., Krarup T., Deacon C.F., Madsbad S., Holst J.J. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001, 50:609-613.
5. Muscelli E., Mari A., Casolaro A., Camastra S., Seghieri G., Gastaldelli A., Holst J.J., Ferrannini E. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008, 57:1340-1348.
6. Kappe C., Patrone C., Holst J.J., Zhang Q., Sjoholm A. Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells. J. Gastroenterol. 2012.
7. Mannucci E., Ognibene A., Cremasco F., Bardini G., Mencucci A., Pierazzuoli E., Ciani S., Messeri G., Rotella C.M. Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects. Diabetes Care 2001, 24:489-494.
8. Listenberger L.L., Han X., Lewis S.E., Cases S., Farese R.V., Ory D.S., Schaffer J.E. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA 2003, 100:3077-3082.
9. Yuan H., Zhang X., Huang X., Lu Y., Tang W., Man Y., Wang S., Xi J., Li J. NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of beta-cells via JNK, p38 MAPK and p53 pathways. PLoS One 2010, 5:e15726.
10. Lee Y.C., Asa S.L., Drucker D.J. Glucagon gene 5'-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice. J. Biol. Chem. 1992, 267:10705-10708.
11. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
12. Kazuki Hattori I.N., Runchel Christopher, Ichijo Hidenori The roles of ASK family proteins in stress responses and diseases. Cell Commun. Signal. 2009, 7.
13. Kleinfeld A.M., Prothro D., Brown D.L., Davis R.C., Richieri G.V., DeMaria A. Increases in serum unbound free fatty acid levels following coronary angioplasty. Am. J. Cardiol. 1996, 78:1350-1354.
14. Shafrir E. Partition of unesterified fatty acids in normal and nephrotic syndrome serum and its effect on serum electrophoretic pattern. J. Clin. Invest. 1958, 37:1775-1782.
15. Saifer A., Goldman L. The free fatty acids bound to human serum albumin. J. Lipid Res. 1961, 2:268-270.
16. Brubaker P.L., Schloos J., Drucker D.J. Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line. Endocrinology 1998, 139:4108-4114.
17. Drucker D.J., Jin T., Asa S.L., Young T.A., Brubaker P.L. Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line. Mol. Endocrinol. 1994, 8:1646-1655.
18. Piro S., Rabuazzo A.M., Renis M., Purrello F. Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets. J. Endocrinol. Invest. 2012, 35:504-510.
19. Schulz E., Dopheide J., Schuhmacher S., Thomas S.R., Chen K., Daiber A., Wenzel P., Munzel T., Keaney J.F. Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation 2008, 118:1347-1357.
20. Proctor W.R., Bourdet D.L., Thakker D.R. Mechanisms underlying saturable intestinal absorption of metformin. Drug Metab. Dispos. 2008, 36:1650-1658.