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Volumn 49, Issue 4, 2012, Pages 330-341

Clinical Results With the DNA Hypomethylating Agent 5-Aza-2'-Deoxycytidine (Decitabine) in Patients With Myelodysplastic Syndromes: An Update

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTHRACYCLINE; ARYLBUTYRIC ACID DERIVATIVE; AZACITIDINE; BUSULFAN; CARMUSTINE; ENTINOSTAT; FLUDARABINE; GEMTUZUMAB OZOGAMICIN; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; LENALIDOMIDE; MELPHALAN; RETINOIC ACID; THALIDOMIDE; THYMOCYTE ANTIBODY; TIPIFARNIB; VALPROIC ACID;

EID: 84867606293     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2012.08.001     Document Type: Article
Times cited : (34)

References (62)
  • 1
    • 0025895882 scopus 로고
    • Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation
    • Lübbert M., Miller C.W., Koeffler H.P. Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation. Blood 1991, 78:345-356.
    • (1991) Blood , vol.78 , pp. 345-356
    • Lübbert, M.1    Miller, C.W.2    Koeffler, H.P.3
  • 2
    • 78650983952 scopus 로고    scopus 로고
    • Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
    • Lugthart S., Figueroa M.E., Bindels E., et al. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood 2011, 117:234-241.
    • (2011) Blood , vol.117 , pp. 234-241
    • Lugthart, S.1    Figueroa, M.E.2    Bindels, E.3
  • 3
    • 84878414253 scopus 로고    scopus 로고
    • US Food and Drug Administration, 1-16
    • Dacogen™ (decitabine) for injection US Food and Drug Administration, 1-16. http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021790lbl.pdf.
    • Dacogen™ (decitabine) for injection
  • 4
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones P.A., Taylor S.M. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980, 20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 5
    • 0034105545 scopus 로고    scopus 로고
    • DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action
    • Lübbert M. DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action. Curr Top Microbiol Immunol 2000, 249:135-164.
    • (2000) Curr Top Microbiol Immunol , vol.249 , pp. 135-164
    • Lübbert, M.1
  • 6
    • 0024956889 scopus 로고
    • 5-Aza-2'-deoxycytidine as a differentiation inducer in acute myeloid leukaemias and myelodysplastic syndromes of the elderly
    • Pinto A., Zagonel V., Attadia V., et al. 5-Aza-2'-deoxycytidine as a differentiation inducer in acute myeloid leukaemias and myelodysplastic syndromes of the elderly. Bone Marrow Transplant 1989, 4(Suppl 3):28-32.
    • (1989) Bone Marrow Transplant , vol.4 , Issue.SUPPL. 3 , pp. 28-32
    • Pinto, A.1    Zagonel, V.2    Attadia, V.3
  • 7
    • 0027221806 scopus 로고
    • 5-Aza-2'-deoxycytidine (decitabine) induces trilineage response in unfavourable myelodysplastic syndromes
    • Zagonel V., Re Lo G., Marotta G., et al. 5-Aza-2'-deoxycytidine (decitabine) induces trilineage response in unfavourable myelodysplastic syndromes. Leukemia 1993, 7(Suppl 1):30-35.
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 1 , pp. 30-35
    • Zagonel, V.1    Re Lo, G.2    Marotta, G.3
  • 8
    • 29144473297 scopus 로고    scopus 로고
    • An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2'-deoxycytidine (decitabine) in 177 patients
    • Wijermans P.W., Lübbert M., Verhoef G., Klimek V., Bosly A. An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2'-deoxycytidine (decitabine) in 177 patients. Ann Hematol 2005, 84(Suppl 1):9-17.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 1 , pp. 9-17
    • Wijermans, P.W.1    Lübbert, M.2    Verhoef, G.3    Klimek, V.4    Bosly, A.5
  • 9
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2'-deoxycytidine (decitabine) treatment
    • Daskalakis M., Nguyen T.T., Nguyen C., et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2'-deoxycytidine (decitabine) treatment. Blood 2002, 100:2957-2964.
    • (2002) Blood , vol.100 , pp. 2957-2964
    • Daskalakis, M.1    Nguyen, T.T.2    Nguyen, C.3
  • 10
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa J.-P.J. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004, 103:1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.-P.J.1
  • 11
    • 0027501999 scopus 로고
    • Phase I study of topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia
    • Kantarjian H.M., Beran M., Ellis A., et al. Phase I study of topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia. Blood 1993, 81:1146-1151.
    • (1993) Blood , vol.81 , pp. 1146-1151
    • Kantarjian, H.M.1    Beran, M.2    Ellis, A.3
  • 12
    • 0037092980 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
    • Kantarjian H.M., Cortes J., O'Brien S., et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood 2002, 99:3547-3553.
    • (2002) Blood , vol.99 , pp. 3547-3553
    • Kantarjian, H.M.1    Cortes, J.2    O'Brien, S.3
  • 13
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    • Kantarjian H., Issa J.-P.J., Rosenfeld C.S., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006, 106:1794-1803.
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.-P.J.2    Rosenfeld, C.S.3
  • 14
    • 0034554786 scopus 로고    scopus 로고
    • Report of an international working group to standardize response criteria for myelodysplastic syndromes
    • Cheson B.D., Bennett J.M., Kantarjian H., et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood 2000, 96:3671-3674.
    • (2000) Blood , vol.96 , pp. 3671-3674
    • Cheson, B.D.1    Bennett, J.M.2    Kantarjian, H.3
  • 15
    • 79956294708 scopus 로고    scopus 로고
    • Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III Study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
    • Lübbert M., Suciu S., Baila L., et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III Study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011, 29:1987-1996.
    • (2011) J Clin Oncol , vol.29 , pp. 1987-1996
    • Lübbert, M.1    Suciu, S.2    Baila, L.3
  • 16
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian H., Oki Y., Garcia-Manero G., et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007, 109:52-57.
    • (2007) Blood , vol.109 , pp. 52-57
    • Kantarjian, H.1    Oki, Y.2    Garcia-Manero, G.3
  • 17
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia
    • Cheson B.D., Bennett J.M., Kopecky K.J., et al. Revised recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol 2003, 21:4642-4649.
    • (2003) J Clin Oncol , vol.21 , pp. 4642-4649
    • Cheson, B.D.1    Bennett, J.M.2    Kopecky, K.J.3
  • 18
    • 33745968917 scopus 로고    scopus 로고
    • Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
    • Cheson B.D., Greenberg P.L., Bennett J.M., et al. Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 2006, 108:419-425.
    • (2006) Blood , vol.108 , pp. 419-425
    • Cheson, B.D.1    Greenberg, P.L.2    Bennett, J.M.3
  • 19
    • 33846236840 scopus 로고    scopus 로고
    • Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome
    • Kantarjian H.M., O'Brien S., Shan J., et al. Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome. Cancer 2007, 109:265-273.
    • (2007) Cancer , vol.109 , pp. 265-273
    • Kantarjian, H.M.1    O'Brien, S.2    Shan, J.3
  • 20
    • 33644861229 scopus 로고    scopus 로고
    • Bayesian clinical trials
    • Berry D.A. Bayesian clinical trials. Nat Rev Drug Discov 2006, 5:27-36.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 27-36
    • Berry, D.A.1
  • 21
    • 33947281469 scopus 로고    scopus 로고
    • Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience
    • Kantarjian H.M., O'Brien S., Huang X., et al. Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience. Cancer 2007, 109:1133-1137.
    • (2007) Cancer , vol.109 , pp. 1133-1137
    • Kantarjian, H.M.1    O'Brien, S.2    Huang, X.3
  • 22
    • 68949145132 scopus 로고    scopus 로고
    • Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the Alternative Dosing for Outpatient Treatment (ADOPT) trial
    • Steensma D.P., Baer M.R., Slack J.L., et al. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the Alternative Dosing for Outpatient Treatment (ADOPT) trial. J Clin Oncol 2009, 27:3842-3848.
    • (2009) J Clin Oncol , vol.27 , pp. 3842-3848
    • Steensma, D.P.1    Baer, M.R.2    Slack, J.L.3
  • 23
    • 71149113328 scopus 로고    scopus 로고
    • Decitabine treatment of patients with higher-risk myelodysplastic syndromes
    • Steensma D.P. Decitabine treatment of patients with higher-risk myelodysplastic syndromes. Leuk Res 2009, 33(Suppl 2):S12-S17.
    • (2009) Leuk Res , vol.33 , Issue.SUPPL. 2
    • Steensma, D.P.1
  • 24
    • 78650058272 scopus 로고    scopus 로고
    • Decitabine in myelodysplastic syndromes and chronic myelomonocytic leukemia: Argentinian/South Korean multi-institutional clinical experience
    • Iastrebner M., Jang J.H., Nucifora E., et al. Decitabine in myelodysplastic syndromes and chronic myelomonocytic leukemia: Argentinian/South Korean multi-institutional clinical experience. Leuk Lymphoma 2010, 51:2250-2257.
    • (2010) Leuk Lymphoma , vol.51 , pp. 2250-2257
    • Iastrebner, M.1    Jang, J.H.2    Nucifora, E.3
  • 25
    • 80053648633 scopus 로고    scopus 로고
    • Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial
    • Braun T., Itzykson R., Renneville A., et al. Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial. Blood 2011, 118:3824-3831.
    • (2011) Blood , vol.118 , pp. 3824-3831
    • Braun, T.1    Itzykson, R.2    Renneville, A.3
  • 26
    • 80053622261 scopus 로고    scopus 로고
    • A prospective multicenter observational study of decitabine treatment in Korean patients with myelodysplastic syndrome
    • Lee J.-H., Jang J.H., Park J., et al. A prospective multicenter observational study of decitabine treatment in Korean patients with myelodysplastic syndrome. Haematologica 2011, 96:1441-1447.
    • (2011) Haematologica , vol.96 , pp. 1441-1447
    • Lee, J.-H.1    Jang, J.H.2    Park, J.3
  • 27
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
    • Vardiman J.W., Thiele J., Arber D.A., et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009, 114:937-951.
    • (2009) Blood , vol.114 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 28
    • 0019952276 scopus 로고
    • Proposals for the classification of the myelodysplastic syndromes
    • Bennett J.M., Catovsky D., Daniel M.T., et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982, 51:189-199.
    • (1982) Br J Haematol , vol.51 , pp. 189-199
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 29
    • 0030985018 scopus 로고    scopus 로고
    • Continuous infusion of low-dose 5-aza-2'-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome
    • Wijermans P., Krulder J., Huijgens P., Neve P. Continuous infusion of low-dose 5-aza-2'-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome. Leukemia 1997, 11:1-5.
    • (1997) Leukemia , vol.11 , pp. 1-5
    • Wijermans, P.1    Krulder, J.2    Huijgens, P.3    Neve, P.4
  • 30
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients
    • Wijermans P., Lübbert M., Verhoef G., et al. Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 2000, 18:956-962.
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lübbert, M.2    Verhoef, G.3
  • 32
    • 76549103505 scopus 로고    scopus 로고
    • Decitabine versus 5-azacitidine for the treatment of myelodysplastic syndrome: adjusted indirect meta-analysis
    • Kumar A., List A.F., Hozo I., Komrokji R., Djulbegovic B. Decitabine versus 5-azacitidine for the treatment of myelodysplastic syndrome: adjusted indirect meta-analysis. Haematologica 2009, 95:340-342.
    • (2009) Haematologica , vol.95 , pp. 340-342
    • Kumar, A.1    List, A.F.2    Hozo, I.3    Komrokji, R.4    Djulbegovic, B.5
  • 33
    • 76549092572 scopus 로고    scopus 로고
    • 5-Azacitidine prolongs overall survival in patients with myelodysplastic syndrome-A systematic review and meta-analysis
    • Gurion R., Vidal L., Gafter-Gvili A., et al. 5-Azacitidine prolongs overall survival in patients with myelodysplastic syndrome-A systematic review and meta-analysis. Haematologica 2010, 95:303-310.
    • (2010) Haematologica , vol.95 , pp. 303-310
    • Gurion, R.1    Vidal, L.2    Gafter-Gvili, A.3
  • 34
    • 33646051586 scopus 로고    scopus 로고
    • Superiority of prolonged low-dose azanucleoside administration?. Results of 5-aza-2'-deoxycytidine retreatment in high-risk myelodysplasia patients
    • Rüter B., Wijermans P.W., Lübbert M. Superiority of prolonged low-dose azanucleoside administration?. Results of 5-aza-2'-deoxycytidine retreatment in high-risk myelodysplasia patients. Cancer 2006, 106:1744-1750.
    • (2006) Cancer , vol.106 , pp. 1744-1750
    • Rüter, B.1    Wijermans, P.W.2    Lübbert, M.3
  • 35
    • 42049097308 scopus 로고    scopus 로고
    • Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine
    • Borthakur G., Ahdab S.E., Ravandi F., et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma 2008, 49:690-695.
    • (2008) Leuk Lymphoma , vol.49 , pp. 690-695
    • Borthakur, G.1    Ahdab, S.E.2    Ravandi, F.3
  • 36
    • 80051992418 scopus 로고    scopus 로고
    • Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure
    • Prebet T., Gore S.D., Esterni B., et al. Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol 2011, 29:3322-3327.
    • (2011) J Clin Oncol , vol.29 , pp. 3322-3327
    • Prebet, T.1    Gore, S.D.2    Esterni, B.3
  • 37
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux P., Mufti G.J., Hellström-Lindberg E., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10:223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3
  • 38
    • 70350506791 scopus 로고    scopus 로고
    • Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    • Fandy T.E., Herman J.G., Kerns P., et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 2009, 114:2764-2773.
    • (2009) Blood , vol.114 , pp. 2764-2773
    • Fandy, T.E.1    Herman, J.G.2    Kerns, P.3
  • 39
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore S.D., Baylin S., Sugar E., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006, 66:6361-6369.
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3
  • 40
    • 78650172030 scopus 로고    scopus 로고
    • Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
    • Itzykson R., Thépot S., Quesnel B., et al. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine. Blood 2011, 117:403-411.
    • (2011) Blood , vol.117 , pp. 403-411
    • Itzykson, R.1    Thépot, S.2    Quesnel, B.3
  • 41
    • 70349436151 scopus 로고    scopus 로고
    • Repeated responses of an elderly patient with high-risk myelodysplastic syndrome to sequential therapy with tipifarnib, 5-azacitidine, and decitabine
    • Möller I., Blum S., Gattermann N., et al. Repeated responses of an elderly patient with high-risk myelodysplastic syndrome to sequential therapy with tipifarnib, 5-azacitidine, and decitabine. Ann Hematol 2009, 88:1141-1144.
    • (2009) Ann Hematol , vol.88 , pp. 1141-1144
    • Möller, I.1    Blum, S.2    Gattermann, N.3
  • 42
    • 34248363673 scopus 로고    scopus 로고
    • A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
    • Fenaux P., Raza A., Mufti G.J., et al. A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome. Blood 2007, 109:4158-4163.
    • (2007) Blood , vol.109 , pp. 4158-4163
    • Fenaux, P.1    Raza, A.2    Mufti, G.J.3
  • 43
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with conventional care regimens in higher-risk myelodysplastic syndromes: results of a randomised, phase III study
    • Fenaux P., Mufti G.J., Hellstrom-Lindberg E., et al. Efficacy of azacitidine compared with conventional care regimens in higher-risk myelodysplastic syndromes: results of a randomised, phase III study. Lancet Oncol 2009, 10:223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 44
    • 84878412586 scopus 로고    scopus 로고
    • Decitabine is effective in patients with myelodysplastic syndromes who failed prior intensive regimen: no negative impact of prior therapy
    • Jabbour E., Kantarjian H., Kadia T., et al. Decitabine is effective in patients with myelodysplastic syndromes who failed prior intensive regimen: no negative impact of prior therapy. 52nd ASH Annual Meeting (poster) 2010.
    • (2010) 52nd ASH Annual Meeting (poster)
    • Jabbour, E.1    Kantarjian, H.2    Kadia, T.3
  • 45
    • 84867583462 scopus 로고    scopus 로고
    • Clinical activity of DNA methyltransferase inhibitors in therapy-related myelodyplastic syndromes: a retrospective study
    • 52nd ASH Annual Meeting and Exposition, poster session: Myelodysplastic Syndromes: Poster Board I-871; 201AD.
    • Tees MT, Dolezal EK, Nimer SD, Klimek VM. Clinical activity of DNA methyltransferase inhibitors in therapy-related myelodyplastic syndromes: a retrospective study. 52nd ASH Annual Meeting and Exposition 2010, poster session: Myelodysplastic Syndromes: Poster Board I-871; 201AD.
    • (2010)
    • Tees, M.T.1    Dolezal, E.K.2    Nimer, S.D.3    Klimek, V.M.4
  • 46
    • 67549109557 scopus 로고    scopus 로고
    • Feasibility of allo-SCT after hypomethylating therapy with decitabine for myelodysplastic syndrome
    • De Padua Silva L., de Lima M., Kantarjian H., et al. Feasibility of allo-SCT after hypomethylating therapy with decitabine for myelodysplastic syndrome. Bone Marrow Transplant 2009, 43:839-843.
    • (2009) Bone Marrow Transplant , vol.43 , pp. 839-843
    • De Padua Silva, L.1    de Lima, M.2    Kantarjian, H.3
  • 47
    • 79955961315 scopus 로고    scopus 로고
    • The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications
    • Campo E., Swerdlow S.H., Harris N.L., et al. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 2011, 117:5019-5032.
    • (2011) Blood , vol.117 , pp. 5019-5032
    • Campo, E.1    Swerdlow, S.H.2    Harris, N.L.3
  • 48
    • 70749131024 scopus 로고    scopus 로고
    • Non-intensive treatment with low-dose 5-aza-2'-deoxycytidine (DAC) prior to allogeneic blood SCT of older MDS/AML patients
    • Lübbert M., Bertz H., Rüter B., et al. Non-intensive treatment with low-dose 5-aza-2'-deoxycytidine (DAC) prior to allogeneic blood SCT of older MDS/AML patients. Bone Marrow Transplant 2009, 44:585-588.
    • (2009) Bone Marrow Transplant , vol.44 , pp. 585-588
    • Lübbert, M.1    Bertz, H.2    Rüter, B.3
  • 49
    • 61549137657 scopus 로고    scopus 로고
    • Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic subgroups of older AML patients: results of the FR00331 multicenter phase II study
    • Lübbert M., Rüter B., Claus R., et al. Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic subgroups of older AML patients: results of the FR00331 multicenter phase II study. Blood 2007, 110(Suppl):300a.
    • (2007) Blood , vol.110 , Issue.SUPPL.
    • Lübbert, M.1    Rüter, B.2    Claus, R.3
  • 50
    • 0038518581 scopus 로고    scopus 로고
    • Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia
    • Bertz H., Potthoff K., Finke J. Allogeneic stem-cell transplantation from related and unrelated donors in older patients with myeloid leukemia. J Clin Oncol 2003, 21:1480-1484.
    • (2003) J Clin Oncol , vol.21 , pp. 1480-1484
    • Bertz, H.1    Potthoff, K.2    Finke, J.3
  • 51
    • 33847347400 scopus 로고    scopus 로고
    • End points to establish the efficacy of new agents in the treatment of acute leukemia
    • Appelbaum F.R., Rosenblum D., Arceci R.J., et al. End points to establish the efficacy of new agents in the treatment of acute leukemia. Blood 2007, 109:1810-1816.
    • (2007) Blood , vol.109 , pp. 1810-1816
    • Appelbaum, F.R.1    Rosenblum, D.2    Arceci, R.J.3
  • 52
    • 47649090155 scopus 로고    scopus 로고
    • Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies
    • Marks R., Potthoff K., Hahn J., et al. Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies. Blood 2008, 112:415-425.
    • (2008) Blood , vol.112 , pp. 415-425
    • Marks, R.1    Potthoff, K.2    Hahn, J.3
  • 53
    • 76149131707 scopus 로고    scopus 로고
    • Hypomethylating agent induction therapy followed by hematopoietic cell transplantation is feasible in patients with myelodysplastic syndromes
    • Cogle C.R., Imanirad I., Wiggins L.E., et al. Hypomethylating agent induction therapy followed by hematopoietic cell transplantation is feasible in patients with myelodysplastic syndromes. Clin Adv Hematol Oncol 2010, 8:40-46.
    • (2010) Clin Adv Hematol Oncol , vol.8 , pp. 40-46
    • Cogle, C.R.1    Imanirad, I.2    Wiggins, L.E.3
  • 55
    • 80051604949 scopus 로고    scopus 로고
    • Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
    • Scandura J.M., Roboz G.J., Moh M., et al. Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood 2011, 118:1472-1480.
    • (2011) Blood , vol.118 , pp. 1472-1480
    • Scandura, J.M.1    Roboz, G.J.2    Moh, M.3
  • 56
    • 34548529948 scopus 로고    scopus 로고
    • Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
    • Blum W., Klisovic R.B., Hackanson B., et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 2007, 25:3884-3891.
    • (2007) J Clin Oncol , vol.25 , pp. 3884-3891
    • Blum, W.1    Klisovic, R.B.2    Hackanson, B.3
  • 57
    • 84867621669 scopus 로고    scopus 로고
    • Vorinostat in combination with Decitabine for the treatment of relapsed or newly diagnosed acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS): A phase I, dose-escalation study. 51st ASH Annual Meeting And Exposition, poster session: Acute Myeloid Leukemia: poster board II-66.
    • Kirschbaum M, Gojo I, Goldberg S, Kujawski L. Vorinostat in combination with Decitabine for the treatment of relapsed or newly diagnosed acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS): A phase I, dose-escalation study. 51st ASH Annual Meeting And Exposition 2009, poster session: Acute Myeloid Leukemia: poster board II-66.
    • (2009)
    • Kirschbaum, M.1    Gojo, I.2    Goldberg, S.3    Kujawski, L.4
  • 58
    • 84878378264 scopus 로고    scopus 로고
    • Phase I study of panobinostat plus decitabine in elderly patients with advanced MDS or AML
    • 53rd ASH Annual Meeting and Exposition, poster session: Acute Myeloid Leukemia: poster board I-40.
    • Uy GL, Abboud CN, Cashen AF, et al. Phase I study of panobinostat plus decitabine in elderly patients with advanced MDS or AML. 53rd ASH Annual Meeting and Exposition 2011, poster session: Acute Myeloid Leukemia: poster board I-40.
    • (2011)
    • Uy, G.L.1    Abboud, C.N.2    Cashen, A.F.3
  • 59
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G., Kantarjian H.M., Sanchez-Gonzalez B., et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood 2006, 108:3271-3279.
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 60
    • 84857747740 scopus 로고    scopus 로고
    • A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy
    • Lübbert M., Rüter B.H., Claus R., et al. A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica 2012, 97:393-401.
    • (2012) Haematologica , vol.97 , pp. 393-401
    • Lübbert, M.1    Rüter, B.H.2    Claus, R.3
  • 61
    • 0038142344 scopus 로고    scopus 로고
    • 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?
    • Sigalotti L., Altomonte M., Colizzi F., et al. 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?. Blood 2003, 101:4644-4646.
    • (2003) Blood , vol.101 , pp. 4644-4646
    • Sigalotti, L.1    Altomonte, M.2    Colizzi, F.3
  • 62
    • 77952952304 scopus 로고    scopus 로고
    • The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells
    • Almstedt M., Blagitko-Dorfs N., Duque-Afonso J., et al. The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells. Leuk Res 2010, 34:899-905.
    • (2010) Leuk Res , vol.34 , pp. 899-905
    • Almstedt, M.1    Blagitko-Dorfs, N.2    Duque-Afonso, J.3


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