Cancer of unknown primary: From immunohistochemistry to gene expression profiling

Journal of Clinical Oncology

Volumn 30, Issue 29, 2012, Pages

  Chiang, Wendy M ^a   Kapadia, Mitesh ^a   Laver, Nora V ^a   Nystrom, John Scott ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 19; CYTOKERATIN 7; EOSIN; HEMATOXYLIN; MESSENGER RNA;

AGED; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER OF UNKNOWN PRIMARY SITE; CANCER PATIENT; CANCER RADIOTHERAPY; CASE REPORT; CHINESE; COMPUTER ASSISTED TOMOGRAPHY; EYE CANCER; EYELID ADENOCARCINOMA; EYELID BIOPSY; EYELID DISEASE; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; SMOKING;

ADENOCARCINOMA; AGED; BIOPSY, NEEDLE; COMBINED MODALITY THERAPY; EYELID NEOPLASMS; FOLLOW-UP STUDIES; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MICROARRAY ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOPLASMS, UNKNOWN PRIMARY; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT REFUSAL;

EID: 84867600956     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.41.1827     Document Type: Article

References (28)

1. Greco FA, Hainsworth JD: Cancer of unknown primary site, in Devita VT Jr, Hellman S, Rosenberg (eds): Cancer: Principles and Practice of Oncology (ed 8). Philadelphia, PA, Lippincott, 2008, pp 2363-2387
2. Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2009. CA Cancer J Clin 59:225-249, 2009
3. Varadhachary GR, Abbruzzese JL, Lenzi R: Diagnostic strategies for unknown primary cancer. Cancer 100:1776-1785, 2004 (Pubitemid 38529553)
4. Tong KB, Murtagh KN, Hubert HB, et al: Incidence, costs of care and survival of Medicare beneficiaries diagnosed with carcinoma of unknown primary (CUP). Presented at the Association of Molecular Pathology Annual Meeting, Orlando, FL, November 17, 2006
5. Korde LA, Zujewski JA, Kamin L, et al: Multidisciplinary meeting on male breast cancer: Summary and research recommendations. J Clin Oncol 28:2114-2122, 2010
6. Zhang GJ, Adachi I, Yin DF, et al: Eyelid metastasis from breast cancer showing marked response to chemotherapy. Jpn J Clin Oncol 25:10-15, 1995
7. Albert DM, Rubenstein RA, Scheie HG: Tumor metastasis to the eye. I. Incidence in 213 adult patients with generalized malignancy. Am J Ophthalmol 63:723-726, 1967
8. Demirci H, Shields CL, Chao AN, et al: Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol 136:264-271, 2003 (Pubitemid 36904073)
9. Francone E, Murelli F, Paroldi A, et al: Orbital swelling as a first symptom in breast carcinoma diagnosis: A case report. J Med Case Rep 4:211, 2010
10. Valenzuela AA, Archibald CW, Fleming B, et al: Orbital metastasis: Clinical features, management and outcome. Orbit 28:153-159, 2009
11. Ratanatharathorn V, Powers WE, Grimm J, et al: Eye metastasis from carcinoma of the breast: Diagnosis, radiation treatment and results. Cancer Treat Rev 18:261-276, 1991 (Pubitemid 23008969)
12. Reference deleted
13. Park SY, Kim BH, Kim JH, et al: Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma. Arch Pathol Lab Med 131:1561-1567, 2007
14. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology - Occult primary (cancer of unknown primary), Version 1.2012. http://www.nccn.org/professionals/physician-gls/pdf/occult.pdf
15. Bhargava R, Dabbs D: Diagnostic immunohistochemistry - Theranostic and genomic applications, in Immunohistology of Metastatic Carcinomas of Unknown Primary (ed 3). Philadelphia, PA, Saunders, 2010
16. Pentheroudakis G, Golfinopoulos V, Pavlidis N: Switching benchmarks in cancer of unknown primary: From autopsy to microarray. Eur J Cancer 43:2026-2036, 2007 (Pubitemid 47380362)
17. Ma XJ, Patel R, Wang X, et al: Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay. Arch Pathol Lab Med 130:465-473, 2006
18. Talantov D, Baden J, Jatkoe T, et al: A quantitative reverse transcriptase-polymerase chain reaction assay to identify metastatic carcinoma tissue of origin. J Mol Diagn 8:320-329, 2006 (Pubitemid 44063808)
19. Rosenfeld N, Aharonov R, Meiri E, et al: MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 26:462-469, 2008 (Pubitemid 351501813)
20. Monzon FA, Lyons-Weiler M, Buturovic LJ, et al: Multicenter validation of a 1,550-gene expression profile for identification of tumor tissue of origin. J Clin Oncol 27:2503-2508, 2009
21. Varadhachary GR, Talantov D, Raber MN, et al: Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation. J Clin Oncol 26:4442-4448, 2008
22. Horlings HM, van Laar RK, Kerst JM, et al: Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J Clin Oncol 26:4435-4441, 2008
23. Varadhachary GR, Spector Y, Abbruzzese JL, et al: Prospective gene signature study using microRNA to identify the tissue of origin in patients with carcinoma of unknown primary. Clin Cancer Res 17:4063-4070, 2011
24. Pollack A: Genetic tests may reveal source of mystery tumors. New York Times on the Web, March 10, 2009. http://www.nytimes.com/2009/03/10/health/ 10tumo.html?pagewanted=all
25. Greco FA, Spigel DR, Yardley DA, et al: Molecular Profiling in unknown primary cancer: Accuracy of tissue of origin prediction. Oncologist 15:500-506, 2010
26. Couch FJ, Farid LM, DeShano ML, et al: BRCA germline mutations in male breast cancer cases and breast cancer families. Nat Genet 13:123-125, 1996 (Pubitemid 126528243)
27. Haraldsson K, Loman N, Zhang QX, et al: BRCA2 germ-line mutations are frequent in male breast cancer patients without a family history of the disease. Cancer Res 58:1367-1371, 1998 (Pubitemid 28193591)
28. Thorlacius S, Tryggvadottir L, Olafsdottir GH, et al: Linkage to BRCA2 region in hereditary male breast cancer. Lancet 346:544-545, 1995