Synthesis, characterization and biological screening of new spirochromanones

Journal of Chemical and Pharmaceutical Research

Volumn 4, Issue 7, 2012, Pages 3377-3382

  Gajera, Nilesh N ^a   Patel, Mukesh C ^a  

^a PS Science and HDPatel Arts College   (India)

Author keywords

Acetyl coa carboxylase (ACC); Antimicrobial activity; Minimum inhibitory concentration (MIC); Spectral analysis; Spirochromanones

Indexed keywords

ACETYL-COA CARBOXYLASE; ANTI-BACTERIAL ACTIVITY; ANTI-FUNGAL ACTIVITY; ANTI-MICROBIAL ACTIVITY; BIOLOGICAL SCREENING; MINIMUM INHIBITORY CONCENTRATION; ORTHO POSITION; PARA POSITION; PATHOGENIC STRAINS; SPECTROSCOPIC TECHNIQUE; SPIROCHROMANONES;

MASS SPECTROMETRY; SPECTRUM ANALYSIS;

CONDENSATION REACTIONS;

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CHEMICAL COMPOUND; CIPROFLOXACIN; CYANO GROUP; DIFLUOROMETHOXY GROUP; FLUCONAZOLE; FLUORO GROUP; HALOGEN; METHYL GROUP; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(2 CHLORO 4 FLUOROPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(3 CYANO 4 FLUOROPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(3,5 DIMETHYLPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(4 BROMOPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(4 CYANOPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(4 FLUORO 2 METHYLPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 2 [(4 ISOPROPYLPHENYL)SULFONYLAMINO] 3 METHYLBUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 3 METHYL 2 (O TOLYLSULFONYLAMINO)BUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 3 METHYL 2 [(3,4,5 TRIFLUOROPHENYL)SULFONYLAMINO]BUTANAMIDE; N [2 (6 FLUORO 4 OXO 2 PROPYLCHROMAN 2 YL)ETHYL] 3 METHYL 2 [[4 (TRIFLUOROMETHOXY)PHENYL]SULFONYLAMINO]BUTANAMIDE; SPIROCHROMANONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CHEMICAL REACTION; CONDENSATION; CONTROLLED STUDY; COUPLING; CYCLIZATION; DEPROTATION; DRUG SCREENING; DRUG SYNTHESIS; FUNGAL STRAIN; INFRARED SPECTROMETRY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84867598995     PISSN: None     EISSN: 09757384     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. X. Zheng, Y. Hu, j. Liu and K. Ouyang, Bioorg. Med. Chem. lett., 2005, 15, 4531.
2. G. Toker, E. Kuepeli, M. Memisoglu, E. Yesilada, J. Ethnopharmaacol, 2004, 95, 393.
3. S.S. Costa, A. Jossang, B. Bodo, M. I. M. Souza and V. L. G. Moraes, J. Net. Prod., 1994, 57, 1503.
4. G. P. Ellis and I. M. Lockhart, Chromans and Tocopherols; Wily: New York, 1981.
5. J. B. Harborne, H. J. Marby, and H. Marby, The Flevonoids; Academic Press; New York, 1975.
6. M. T. Flevin, J. D. Rizzo, A. Khilevich, A. Kucherenko, A. K. Sheinkman, V. Vilaychack, L. Lin, W. Chen, E. M. Greenwood, T. Pengsuperp, J. M. Pezzuto, S. M. Hughes, T. M. Flevin, M. Cibulski, W. A. Boulanger, R. L. Shone and Z. Xu, J. Med. Chem., 1996, 39, 1303.
7. D. Tasdemir, M. Kaiser, R. Brun, V. Yardley, T. J. Schmidt, F. Tosun and P Ruedi, Antimicrob. Agents Chemother., 2006, 50, 1352.
8. R. Mestre, D. Escande and I. Cavero, Euro. J. Pharmacol.,1990, 183, 1239.
9. H. Matsuda, T. Morikawa and M. Yoshikawa, Pure Appl. Chem., 2002, 74,1301.
10. A. P. Jorge, H. Horst, E. De Souza, M. G. Pizzolatti and F. R. M. B. Silva, Chem.-Biol. Interect., 2004, 149, 89.
11. L. C. Chang and A. D. Kinghorn, In Tringali, C., Ed.; Bioactive compounds from Natural sources: Isolation, characterization and Biological properties; Tayler & Francis; London, 2001, Cheptor-5.
12. J. B. Harborne, The Flevanoids, Chapman and Hall; London, 1994.
13. F. M. Dean, Naturally Occurring Oxygen Ring Compounds; Butterworth: London, 1963.
14. T. Lino, H. Jona, J. Shibata, T. Shimamura, T. Yamakawa and L. Yang. MERCK AND CO. (Pat. no: US 20080171767 A1).
15. J.W. Gronwald, Biochem. Soc. Trans., 1994, 22(3), 616.
16. J. Jelenska, A. Sirikhachornkit, R. Haselkorn and P. Gornicki., J. Bio. Chem., 2002, 277 (26), 23208.
17. 17H. f. Vahlensieck, L. Pridzun, H. Reichenbach and A. Hinnen, Current Genetics, 1994, 25(2), 95.
18. C. Freiberg, N. A. Brunner, G. Schiffer, T. Lampe, J. Pohlmann, M. Brands, M. Raabe, D. Habich and K. Ziegelbauer., J. Bio. Chem., 2004, 279 (25), 26066.
19. A. Rattan, In: Antimicrobials in laboratory medicine, New Delhi: Churchill BI, Livingstone, 2000, 85.