Protective effect of crocin against reperfusion- induced cardiac arrhythmias in anaesthetized rats

EXCLI Journal

Volumn 11, Issue , 2012, Pages 20-29

  Jahanbakhsh, Zahra ^a,b   Rasoulian, Bahram ^b   Jafari, Mahvash ^a   Shekarforoush, Shahnaz ^c   Esmailidehaj, Mansour ^d   Mohammadi, Mohammad Taghi ^a   Aghai, Hasan ^a   Salehi, Maryam ^a   Khoshbaten, Ali ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Arrhythmias; Catalase; Crocin; Ischemia; Reperfusion; SOD

Indexed keywords

CATALASE; CROCIN; GLUTATHIONE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HEART ARRHYTHMIA; HEART HEMODYNAMICS; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; RAT; REPERFUSION INJURY; TREATMENT DURATION;

EID: 84867586867     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Abdullaev FI, Espinosa-Aguirre JJ. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detect Prev 2004;28: 426-32.
2. Aebi H. Catalase in vitro. Methods Enzymol 1984;105:121-6.
3. Asai A, Nakano T, Takahashi M, Nagao A. Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. J Agric Food Chem 2005;53:7302-6.
4. Asdaq SMB, Inamdar MN. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotechnol 2010;163: 358-72.
5. Baharvand B, Dehaj ME, Foadaddini M, Rasoulian B, Poorkhalili K, Aghai HW et al. Delayed cardioprotective effects of hyperoxia preconditioning prolonged by intermittent exposure. J Surg Res 2010;160: 53-9.
6. Bernier M, Hearse DJ, Manning AS. Reperfusion-induced arrhythmias and oxygenderived free radicals. Studies with "antifree radical" interventions and a free radical generating system in the isolated perfused rat heart. Circ Res 1986;58:331-40.
7. Boskabady MH, Shafei MN, Shakiba A, Sefidi HS. Effect of aqueous-ethanol extract from Crocus sativus (saffron) on Guinea-pig isolated heart. Phytother Res 2008;22:330-4.
8. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
9. Cohen G, Dembiec D, Marcus J. Measurement of catalase activity in tissue extracts. Anal Biochem 1970;34:30-8.
10. Dhalla NS, Golfman L, Takeda S, Takeda N, Nagano M. Evidence for the role of oxidative stress in acute ischemic heart disease: a brief review. Can J Cardiol 1999;15: 587-93.
11. Dhalla NS, Elmoselhi AB, Hata T, Makino N. Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 2000;47:446-56.
12. Foadoddini M, Esmailidehaj M, Mehrani H, Sadraei SH, Golmanesh L, Wahhabaghai H et al. Pretreatment with hyperoxia reduces in vivo infarct size and cell death by apoptosis with an early and delayed phase of protection. Eur J Cardiothorac Surg 2010; 39:233-40.
13. Goyal SN, Arora S, Sharma AK, Joshi S, Ray R, Bhatia J et al. Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenolinduced cardiotoxicity in rats. Phytomedicine 2010;17:227-32.
14. Hicks JJ, Montes-Cortes DH, Cruz-Dominquez MP, Medina-Santillan R, Olivares-Corichi IM. Antioxidants decrease reperfusion induced arrhythmias in myocardial infarction with ST-elevation. Front Biosci 2007;12:2029-37.
15. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemiareperfusion induced oxidative damage in rats. J Pharm Pharm Sci 2005;22:387-93.
16. Hosseinzadeh H, Modaghegh MH, Saffari Z. Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Alternat Med 2009;6:343-50.
17. Imenshahidi M, Hosseinzadeh H, Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother Res 2010;24:990-4.
18. Joukar S, Najafipour H, Khaksari M, Sepehri G, Shahrokhi N, Dabiri S et al. The effect of saffron consumption on biochemical and histopathological heart indices of rats with myocardial infarction. Cardiovasc Toxicol 2010;10:66-71.
19. Kajiwara H, Ohoi I, Tanonaka K, Takeo S. Effects of a novel cyclohexane dicarboximide derivative, ST-6, on reperfusioninduced arrhythmia in rats. J Pharmacol Sci 2005;98:8-15.
20. Lee I, Lee J, Baek N, Kim D. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin. Biol Pharm Bull 2005;26: 2106-10.
21. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol 2002;282:C227-41.
22. Liu T, Qian Z. Pharmacokinetics of crocetin in rats. Yao Xue Xue Bao 2002;37:367-9.
23. Manning AS, Hearse DJ. Reperfusioninduced arrhythmias: mechanisms and prevention. J Mol Cell Cardiol 1984;16:497-518.
24. Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 2007;1770:578-84.
25. Paller MS, Hoidal JR, Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest 1984;74:1156-64.
26. Rao PR, Vismanath RK. Cardioprotective activity of silymarin in ischemiareperfusion-induced myocardial infarction in albino rats. Exp Clin Cardiol 2007;12: 179-87.
27. Rasoulian B, Jafari M, Noroozzadeh A, Mehrani H, Wahhab-Aghar H, Hashemi-Madani MH et al. Effects of ischemiareperfusin on rat renal tissue antioxidant systems and lipid peroxidation. Acta Med Iranica 2008;46:353-60.
28. Saleem S, Ahmad M, Shmad AS, Yousuf S, Ansari MA, Khan B et al. Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Medicinal Food 2006;9:246-53.
29. Satoh K. Serum lipid peroxidation in cerebrovascular disorders determined by a new colorimetric method. Clin Chim Acta 1978; 90:37-43.
30. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001; 30:1191-212.
31. Srivastava R, Ahmed H, Dixit RK, Dharameveer, Saraf SA. Crocus sativus L. A comprehensive review. Pharmacogn Rev 2010;4:200-8.
32. Takusagawa M, Komori S, Matsumura K, Osada M, Kohno I, Umetani K et al. The inhibitory effects of carvedilol against arrhythmias induced by coronary reperfusion in anesthetized rats. J Cardiovasc Pharmacol Ther 2000;5:105-12.
33. Tietze F. Enzymic method for quantitative determination of nanogram amount of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-22.
34. Turrens JF, Thornton J, Barnard ML, Snyder S, Liu G, Downey JM. Protection from reperfusion injury by preconditioning hearts does not involve increased antioxidant defenses. Am J Physiol 1992;262: H585-9.
35. Walker MJA, Curtis MJ, Hearse DJ, Campbell RWF, Janse MJ, Yellon DM et al. The Lambeth conventions: Guidelines for the study of arrhythmias in ischemia infarction and reperfusion. Cardiovasc Res 1988;22: 447-55.
36. Winterbourn C, Hawkins R, Brian M, Carrell RW. The estimation of red cell superoxide dismutase activity. J Lab Clin Med 1975;85:337-41.
37. Xi L, Qian Z, Du P, Fu J. Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats. Phytomedicine 2007;14:633-6.
38. Zhao G, Gao H, Qiu J, Lu W, Wei X. The molecular mechanism of protective effects of grape seed Proanthocyanidin extract on reperfusion arrhythmias in rats in vivo. Biol Pharm Bull 2010;33:759-62.
39. Zheng YQ, Liu JX, Wang JN, Xu L. Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007;23:86-94.