Effects of a novel cyclohexane dicarboximide derivative, ST-6, on reperfusion-induced arrhythmia in rats

Journal of Pharmacological Sciences

Volumn 98, Issue 1, 2005, Pages 8-15

  Kajiwara, Hiroshi ^a   Ohoi, Itaru ^b   Tanonaka, Kouichi ^c   Takeo, Satoshi ^c  

^a Drug Safety Testing Center Co Ltd   (Japan)

^b NIPPON KAYAKU CO LTD   (Japan)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Arrhythmia; Rat heart; Reperfusion; ST 6

Indexed keywords

2 [4 [4 (CHLOROPHENYL) 4 HYDROXY 1 PIPERIDINYL]BUTYL]HEXAHYDRO 1H ISOINDOL 1,3(2H) DIONE; ANTIARRHYTHMIC AGENT; CYCLOHEXANE DERIVATIVE; DILTIAZEM; IMIDE; LIDOCAINE; PENTOBARBITAL; SEMATILIDE; ST 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; HEART INFARCTION; HEART MUSCLE REPERFUSION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; LEFT CORONARY ARTERY; MALE; NONHUMAN; RAT; SUDDEN DEATH;

EID: 20444393526     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.FP0040815     Document Type: Article

References (30)

1. Takeo S, Tanonaka K, Kajiwara H, Miyake K, Antoku F, Mori H. The effects of a novel cyclohexane dicarboximide derivative, ST-6, on hypoxia/reoxygenation injury in perfused rat heart. Biol Pharm Bull. 2000;23:712-716.
2. Takeo S, Kajiwara H, Tanonaka K, Nasa Y, Nakajima Y, Ohya Y, et al. Cardioprotective effect of a novel cyclohexane dicarboximide derivative, ST-6, against ischemia/reperfusion injury. Drug Develop Res. 2000;51:20-28.
3. Takeo S, Tanonaka K, Hayashi M, Yamamoto K, Liu JX, Kamiyama T, et al. A possible involvement of sodium channel blockade of class-I-type antiarrhythmic agents in postischemic contractile recovery of isolated, perfused hearts. J Pharmacol Exp Ther. 1995;273:1403-1409.
4. Tanonaka K, Kajiwara H, Kameda H, Takasaki A, Takeo S. Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers. Eur J Pharmacol. 1999;372:37-48.
5. Parratt JR. Inhibitors of the slow calcium current and early ventricular arrhythmias. In: Parratt JR, editor. Early arrhythmias resulting from myocardial ischaemia. London: Macmillan; 1982. p. 329-346.
6. He ZS, Komori S, Tamura K, Hashimoto K. Inhibitory effect of moricizine on reperfusion induced tachyarrhythmias in rats. A comparison study with disopyramide and mexiletine. Jpn Circ J. 1992;56:861-865.
7. Corr PB, Pogwizd SM. Mechanisms contributing to arrhythmo-genesis during early myocardial ischemia, subsequent reperfusion, and chronic infarction. Angiology. 1988;39:684-699.
8. Komori S, Sano S, Li BH, Matsumura K, Naitoh A, Mochizuki S, et al. Effects of bidisommide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide. Heart Vessel. 1995;10:7-11.
9. Baraka A, Kawkabani N, Dabbous A, Nawfal M. Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping. J Cardiothorac Vasc Anesthe. 2000;14: 531-533.
10. Tosaki A, Szekeres L, Hearse DJ. Diltiazem and the reduction of reperfusion-induced arrhythmias in the rat: protection is secondary to modification of ischemic injury and heart rate. J Mol Cell Cardiol. 1987;19:441-451.
11. Xue YX, Eto K, Akie Y, Hashimoto K. Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models. Jpn J Pharmacol. 1996;70:129-138.
12. Ohoi I, Ozawa N, Nakamura K. Analysis of factors inducing reperfusion-induced arrhythmia in the anesthetized rat heart: the influence of ischemic zone size and hemodynamics. Folia Pharmacol Jpn (Nippon Yakurigaku Zasshi). 1992;100:87-95. (text in Japanese with English abstract)
13. Selye H, Bajusz E, Grasso S, Mendell P. Simple techniques for the surgical occlusion of coronary vessels in the rat. Angiology. 1960;11:398-407.
14. Manning AS, Hearse DJ. Reperfusion-induced arrhythmias: mechanisms and prevention. J Mol Cell Cardiol. 1984;16:497-518.
15. Curtis MJ, Hearse DJ. Reperfusion-induced arrhythmias are critically dependent upon occluded zone size: relevance to the mechanism of arrhythmogenesis. J Mol Cell Cardiol. 1989;21: 625-637.
16. Walker MJA, Curtis MJ, Hearse DJ, Campbell RWF, Janse MJ, Yellon DM, et al. The Lambeth conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res. 1988;22:447-455.
17. Tsuchihashi K, Curtis M. Influence of tedisamil on the initiation and maintenance of ventricular fibrillation: chemical defibrillation by Ito blockade. J Cardiovasc Pharmacol. 1991;18:445-456.
18. Cobb LA, Baum RS, Alvarez H, Schaffer WA. Resuscitation from out-of-hospital ventricular fibrillation: 4-year follow-up. Circulation. 1975;51/52 Suppl 11:223-228.
19. Janse MJ, Capelle FJL, van Morsink H, Kleber AG, Wilms-Schopman F. Flow of injury current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Circ Res. 1980;47:151-165.
20. 2+ influx. Eur J Pharmacol. 1999;22:233-239.
21. Bernier M, Hearse DJ, Manning AS. Reperfusion-induced arrhythmias and oxygen-derived free radicals. Studies with "anti-free radical" interventions and a free radical-generating system in the isolated perfused rat heart. Circ Res. 1986;58:331-340.
22. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Eng J Med. 1985;312:159-163.
23. Szarszoi O, Asemu G, Vanecek J, Ostadal B, Kolar F. Effects of melatonin on ischemia and reperfusion injury of the rat heart. Cardiovasc Res. 2001;15:251-257.
24. Takusagawa M, Komori S, Matsumura K, Osada M, Kohno I, Umetani K, et al. The inhibitory effects of carvedilol against arrhythmias induced by coronary reperfusion in anesthetized rats. J Cardiiovasc Pharmacol Ther. 2000;5:105-112.
25. Ohoi I, Ozawa N, Nakamura K. Effect of recombinant human superoxide dismutase (r-h-SOD) on reperfusion-induced irreversible arrhythmias in anesthetized rats. Folia Pharmacol Jpn (Nippon Yakurigaku Zasshi). 1993;101:93-99. (text in Japanese with English abstract)
26. Coetzee WA, Dennis SC, Opie LH, Muller CA. Calcium channel blockers and early ischemic ventricular arrhythmias: electrophysiological versus anti-ischemic effects. J Mol Cell Cardiol. 1987;19Suppl 2:77-97.
27. Thandroyen FT. Protective action of calcium channel antagonist agents against ventricular fibrillation in the isolated perfused rat heart. J Mol Cell Cardiol. 1982;14:21-32.
28. Osada M, Sato T, Komori S, Tamura K. The role of oxygen free radicals and extracellular calcium ions in reperfusion-induced arrhythmias. Jpn Circ J. 1991;55:609-616.
29. Colatsky TJ, Follmer CH, Starmer CF. Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation. 1990;82:2235-2242.
30. Carmeliet E. Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol Rev. 1999;79:917-1017.