Injection of L-glutamate into the insular cortex produces sleep apnea and serotonin reduction in rats

Sleep and Breathing

Volumn 16, Issue 3, 2012, Pages 845-853

  Cui, Li ^a   Wang, Jing Hua ^a   Wang, Min ^a   Huang, Min ^b   Wang, Chun Yong ^c   Xia, Huan ^a,b,c   Xu, Jian Guo ^a   Li, Ming Xian ^a   Wang, Shao ^b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b Basic Medical College   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

5 HT; Genioglossus; Insular cortex; L glutamate; Obstructive sleep apnea; Serotonin

Indexed keywords

GLUTAMIC ACID; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; DIAPHRAGM MUSCLE; ELECTROENCEPHALOGRAM; FEMALE; GENIOGLOSSUS MUSCLE; INSULA; MALE; NEUROPATHOLOGY; NONHUMAN; PHARYNGEAL MUSCLE; PRIORITY JOURNAL; RAT; SEROTONIN BLOOD LEVEL; SEROTONIN BRAIN LEVEL; SLEEP DISORDERED BREATHING;

ANIMALS; BRAIN STEM; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ELECTROMYOGRAPHY; FEMALE; GLUTAMIC ACID; INJECTIONS; MALE; RATS; RATS, WISTAR; RESPIRATION; SEROTONIN; SLEEP APNEA, OBSTRUCTIVE;

EID: 84867583109     PISSN: 15209512     EISSN: 15221709     Source Type: Journal    
DOI: 10.1007/s11325-011-0586-x     Document Type: Article

References (42)

1. Mihǎ;icuţǎ; S, Ursoniu S, Lighezan D, Muntean D, Firǎ;-Mlǎ;dinescu O, Horhat R, Frenţ S, Gaiţǎ; D, Tudorache V (2008) Particularities of the association of systemic arterial hypertension in patients with sleep apnea syndrome. Pneumologia 57:227-228
2. Meek D, Chakravorty I (2009) Obstructive sleep apnoea increases risk of cvd. Practitioner 253:17-20
3. Moore P, Bardwell WA, Ancoli-Israel S, Dimsdale JE (2001) Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnea. J Sleep Res 10:303-308
4. Rudnicka A, Pływaczewski R, Jończak L, Górecka D, Sliwiński P (2010) Prevalence of stroke in patients with obstructive sleep apnoea. Pneumonol Alergol Pol 78:121-125
5. Jordan AS, Wellman A, Heinzer RC, Lo YL, Schory K, Dover L, Gautam S, Malhotra A, White DP (2007) Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans. Thorax 62:861-867
6. Eisele DW, Schwartz AR, Smith PL (2003) Tongue neuromuscular and direct hypoglossal nerve stimulation for obstructive sleep apnea. Otolaryngol Clin North Am 36:501-510
7. Mann EA, Burnett T, Cornell S, Ludlow CL (2002) The effect of neuromuscular stimulation of the genioglossus on the hypopharyngeal airway. Laryngoscope 112:351-356
8. Henderson LA, Woo MA, Macey PM, Macey KE, Frysinger RC, Alger JR, Yan-Go F, Harper RM (2003) Neural responses during Valsalva maneuvers in obstructive sleep apnea syndrome. J Appl Physiol 94:1063-1074
9. von leupolgt Andreas, Dahme Bernhard (2005) Cortical substrates for the perception of dyspnea. Chest 128:345-354
10. Schön D, Rosenkranz M, Regelsberger J, Dahme B, Büchel C, von Leupoldt A (2008) Reduced perception of dyspnea and pain after right insular cortex lesions. Am J Respir Crit Care Med 178:1173-1179
11. Ptak K, Yamanishi T, Aungst J, Milescu LS, Zhang R, Richerson GB, Smith JC (2009) Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci 29:3720-3737
12. Wang S, Jiang Y, Xiao JS, Liu MZ, Liu SP (1980) Spontaneous discharges of habenular nucleus and its inhibitory action on nucleus raphe magnus. Sci Bull 25:83-88
13. Li MX, Wang JH, Huang M, Lin WH, Wang M, Yu L, Wang S (2010) Blockage of the habenular nucleus can eliminate dyspnea induced by electrostimulation of the insular cortex. Neural Regen Res 5:1025-1029
14. Real C, Seif I, Adrien J, Escourrou P (2009) Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase a. Respir Physiol Neurobiol 168:230-238
15. Berry RB, Yamaura EM, Gill K, Reist C (1999) Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea. Sleep 22:1087-1092
16. Kraiczi H, Hedner J, Dahlof P, Ejnell H, Carlson J (1999) Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. Sleep 22:61-67
17. Veasey SC (2003) Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. Am J Respir Med 2:21-29
18. Zhong YJ, Zhang C, Wang GF (2010) Effects of 5- hydroxytryptamine and 5-hydroxytryptamine 2A/2 C agonist on the genioglossus activity and sleep apnea in rats. Chin Med J (Engl) 123:2094-2098
19. Schabus M, Dang-Vu TT, Albouy G, Balteau E, Boly M, Carrier J, Darsaud A, Degueldre C, Desseilles M, Gais S, Phillips C, Rauchs G, Schnakers C, Sterpenich V, Vandewalle G, Luxen A, Maquet P (2007) Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep. Proc Natl Acad Sci USA 104:13164-13169
20. Macey KE, Macey PM, Woo MA, Henderson LA, Frysinger RC, Harper RK, Alger JR, Yan-Go F, Harper RM (2006) Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea. Respir Physiol Neurobiol 151:44-60
21. Macefield VG, Gandevia SC, Henderson LA (2006) Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: a fmri study. J Appl Physiol 100:266-273
22. Herigstad M, Hayen A, Wiech K, Pattinson KT (2011) Dyspnoea and the brain. Respir Med 105:809-817
23. Cross RM, Macey PM, Doering LV, Alger JR, Yan-Go FL (2008) Fmri responses to cold pressor challenges in obstructive sleep apnea patients. Sleep 31:1103-1109
24. Macey PM, Kumar R, Alger JR, Yan-Go FL, Harper RM (2008) Brain structural changes in obstructive sleep apnea. Sleep 31:967-977
25. Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, Harper RM (2008) Brain structural changes in obstructive sleep apnea. Sleep 31:967-977
26. Carley DW, Trbovic S, Radulovacki M (1996) Sleep apnea in normal and rem sleep-deprived normotensive wistar-kyoto and spontaneously hypertensive (shr) rats. Physiol Behav 59:827-831
27. Trbovic SM, Radulovacki M, Carley DW (1997) Protoveratrines A and B increase sleep apnea index in Sprague-Dawley rats. J Appl Physiol 83:1602-1606
28. Hu HZ (2005) A course of experiments of medical science. Science Press, Beijing, p 656
29. Aleksandrov VG, Aleksandrova NP, Bagaev VA (2000) Identification of a respiratory related area in the rat insular cortex. Can J Physiol Pharmacol 78:582-586
30. Bagaev V, Aleksandrov V (2006) Visceral-related area in the rat insular cortex. Auton Neurosci 125:16-21
31. Barker JR, Thomas CF, Behan M (2009) Serotonergic projections from the caudal rephe nuclei to the hypoglossal nucleus in male and female rats. Respir Physiol Neurobiol 165:175-184
32. Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ (2005) The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol 564:549-562
33. Saboisky JP, Butler JE, McKenzie DK, Gorman RB, Trinder JA, White DP, Gandevia SC (2007) Neural drive to human genioglossus in obstructive sleep apnoea. J Physiol 585:135-146
34. Luo YM, Wu HD, Tang J, Jolley C, Steier J, Moxham J, Zhong NS, Polkey MI (2008) Neural respiratory drive during apnoeic events in obstructive sleep apnoea. Eur Respir J 31:650-657
35. Luo YM, Tang J, Jolley C, Steier J, Zhong NS, Moxham J, Polkey MI (2009) Distinguishing obstructive from central sleep apnea events: diaphragm electromyogram and esophageal pressure compared. Chest 135:1133-1141
36. Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS (2009) The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. Chest 135:957-964
37. Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A (2009) Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea. Sleep 32:361-368
38. Mahamed S, Mitchell GS (2007) Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea? Exp Physiol 92:27-37
39. Sood S, Liu X, Liu H, Nolan P, Horner RL (2003) 5-ht at hypoglossal motor nucleus and respiratory control of genioglossus muscle in anesthetized rats. Respir Physiol Neurobiol 138:205-221
40. Maier SF, Amat J, Baratta MV, Paul E, Watkins LR (2006) Behavioral control, the medial prefrontal cortex, and resilience. Dialogues Clin Neurosci 8:397-406
41. Oades RD, Halliday GM (1987) Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity. Brain Res 434:117- 165
42. Simmons MS, Clark GT (2009) The potentially harmful medical consequences of untreated sleep-disordered breathing: the evidence supporting brain damage. J Am Dent Assoc J Neurosci 29:3720-3737