Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: A fMRI study

Journal of Applied Physiology

Volumn 100, Issue 1, 2006, Pages 266-273

  Macefield, V G ^a   Gandevia, S C ^a   Henderson, L A ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cardiopulmonary receptors; Medulla; Paraventricular nucleus; Sympathetic activity

Indexed keywords

ADULT; APNEA; ARTICLE; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; CINGULATE GYRUS; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; INSPIRATORY CAPACITY; INSULA; MALE; MEDULLA OBLONGATA; NORMAL HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SYMPATHETIC NERVE; SYMPATHETIC TONE; VALSALVA MANEUVER; ADRENERGIC SYSTEM; BRAIN; BRAIN MAPPING; CLINICAL TRIAL; INNERVATION; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; SKELETAL MUSCLE;

ADULT; APNEA; BRAIN; BRAIN MAPPING; FEMALE; HUMANS; INSPIRATORY CAPACITY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MUSCLE, SKELETAL; SYMPATHETIC NERVOUS SYSTEM; VALSALVA MANEUVER;

EID: 33644823869     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00588.2005     Document Type: Article

References (38)

1. Badoer E, McKinley MJ, Oldfield BJ, and McAllen RM. A comparison of hypotensive and non-hypotensive hemorrhage on Fos expression in spinally projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla. Brain Res 610: 216-223, 1993.
2. Banzett RB, Mulnier HE, Murphy K, Rosen SD, Wise RJ, and Adams L. Breathlessness in humans activates insular cortex. Neuroreport 11: 2117-2120, 2000.
3. Bloch-Salisbury E, Binks AP, Banzett RB, and Schwartzstein RM. Mechanical chest-wall vibration does not relieve air hunger. Respir Physiol Neurobiol 134: 177-190, 2003.
4. Bradley DJ, Paton JF, and Spyer KM. Cardiovascular responses evoked from the fastigial region of the cerebellum in anaesthetized and decerebrate rabbits. J Physiol 392: 475-491, 1987.
5. Butcher KS and Cechetto DF. Autonomic responses of the insular cortex in hypertensive and normotensive rats. Am J Physiol Regul Integr Comp Physiol 268: R214-R222, 1995.
6. Chen YL, Chan SH, and Chan JY. Participation of galanin in baroreflex inhibition of heart rate by hypothalamic PVN in rat. Am J Physiol Heart Circ Physiol 271: H1823-H1828, 1996.
7. Darlington DN, Shinsako J, and Dallman MF. Paraventricular lesions: hormonal and cardiovascular responses to hemorrhage. Brain Res 439: 289-301, 1988.
8. Del Bo A, Sved AF, and Reis DJ. Fastigial stimulation releases vasopressin in amounts that elevate arterial pressure. Am J Physiol Heart Circ Physiol 244: H687-H694, 1983.
9. Evans KC, Banzett RB, Adams L, McKay L, Frackowiak RS, and Corfield DR. BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger. J Neurophysiol 88: 1500-1511, 2002.
10. Friston KJ, Holmes AP, Worsley K, Poline JB, Frith CD, and Frackowiak RS. Statistic parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 2: 189-210, 1995.
11. Harper RM, Bandler R, Spriggs D, and Alger JR. Lateralized and widespread brain activation during transient blood pressure elevation revealed by magnetic resonance imaging. J Comp Neurol 417: 195-204, 2000.
12. Harper RM, Macey PM, Henderson LA, Woo MA, Macey KE, Frysinger RC, Alger JR, Nguyen KP, and Yan-Go FL. fMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects. J Appl Physiol 94: 1583-1595, 2003.
13. Haselton JR, Goering J, and Patel KP. Parvocellular neurons of the paraventricular nucleus are involved in the reduction in renal nerve discharge during isotonic volume expansion. J Auton Nerv Syst 50: 1-11, 1994.
14. Henderson LA, Macey PM, Macey KE, Frysinger RC, Woo MA, Harper RK, Alger JR, Yan-Go FL, and Harper RM. Brain responses associated with the Valsalva maneuver revealed by functional magnetic resonance imaging. J Neurophysiol 88: 3477-3486, 2002.
15. Henderson LA, Richard CA, Macey PM, Runquist ML, Yu PL, Galons JP, and Harper RM. Functional magnetic resonance signal changes in neural structures to baroreceptor reflex activation. J Appl Physiol 96: 693-703, 2004.
16. Kaye DM, Jennings GL, Dart AM, and Esler MD. Differential effect of acute baroreceptor unloading on cardiac and systemic sympathetic tone in congestive heart failure. J Am Coll Cardiol 31: 583-587, 1998.
17. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A 89: 5675-5679, 1992.
18. Logothetis NK, Pauls J, Augath M, Trinath T, and Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 412: 150-157, 2001.
19. Macefield VG. Sustained activation of muscle sympathetic outflow during static lung inflation depends on a high intrathoracic pressure. J Auton Nerv Syst 68: 135-139, 1998.
20. Macefield VG and Wallin BG. Effects of static lung inflation on sympathetic activity in human muscle nerves at rest and during asphyxia. J Auton Nerv Syst 53: 148-156, 1995.
21. Macey PM, Alger JR, Kumar R, Macey KE, Woo MA, and Harper RM. Global BOLD MRI changes to ventilatory challenges in congenital central hypoventilation syndrome. Respir Physiol Neurobiol 139: 41-50, 2003.
22. Macey PM, Macey KE, Henderson LA, Alger JR, Frysinger RC, Woo MA, Yan-Go F, and Harper RM. Functional magnetic resonance imaging responses to expiratory loading in obstructive sleep apnea. Respir Physiol Neurobiol 138: 275-290, 2003.
23. Macey PM, Macey KE, Kumar R, and Harper RM. A method for removal of global effects from fMRI time series. Neuroimage 22: 360-366, 2004.
24. Monda M, Viggiano A, and De Luca V. Functional decortication lowers ventromedial hypothalamic activation induced by hippocampal neostigmine injection. Cereb Cortex 10: 1242-1246, 2000.
25. Moruzzi G. Paleocerebellar inhibition of vasomotor and respiratory carotid sinus reflexes. J Neurophysiol 3: 20-32, 1940.
26. Ogawa S, Lee TM, Nayak AS, and Glynn P. Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14: 68-78, 1990.
27. Parsons LM, Egan G, Liotti M, Brannan S, Denton D, Shade R, Robillard R, Madden L, Abplanalp B, and Fox PT. Neuroimaging evidence implicating cerebellum in the experience of hypercapnia and hunger for air. Proc Natl Acad Sci U S A 98: 2041-2046, 2001.
28. Privette TH, Wang JQ, Ingenito AJ, and Terrian DM. Dentate granule cells as a central cardioregulatory site in the rat. Brain Res 656: 295-301, 1994.
29. Saper CB. Convergence of autonomic and limbic connections in the insular cortex of the rat. J Comp Neurol 210: 163-173, 1982.
30. Shafton AD, Ryan A, and Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res 801: 239-243, 1998.
31. Shafton AD, Ryan A, McGrath B, and Badoer E. Volume expansion does not activate neuronal projections from the NTS or depressor VLM to the RVLM. Am J Physiol Regul Integr Comp Physiol 277: R39-R46, 1999.
32. Sun MK. Medullospinal vasomotor neurones mediate hypotension from stimulation of prefrontal cortex. J Auton Nerv Syst 38: 209-217, 1992.
33. Wang JQ and Ingenito AJ. Cardiovascular effects of microinjection of dynorphin-A(1-8) into the hippocampus in conscious, spontaneously hypertensive and normotensive Wistar-Kyoto rats. Clin Exp Hypertens 16: 229-243, 1994.
34. Wen YQ, Zhu JN, Zhang YP, and Wang JJ. Cerebellar interpositus nuclear inputs impinge on paraventricular neurons of the hypothalamus in rats. Neurosci Lett 370: 25-29, 2004.
35. Westerhaus MJ and Loewy AD. Central representation of the sympathetic nervous system in the cerebral cortex. Brain Res 903: 117-127, 2001.
36. Wurzner G, Chiolero A, Maillard M, Nussberger J, Hayoz D, Brunner HR, and Burnier M. Renal and neurohormonal responses to increasing levels of lower body negative pressure in men. Kidney Int 60: 1469-1476, 2001.
37. Yang Z and Coote JH. Influence of the hypothalamic paraventricular nucleus on cardiovascular neurones in the rostral ventrolateral medulla of the rat. J Physiol 513: 521-530, 1998.
38. Yang Z and Coote JH. Role of GABA and NO in the paraventricular nucleus-mediated reflex inhibition of renal sympathetic nerve activity following stimulation of right atrial receptors in the rat. Exp Physiol 88: 335-342, 2003.