Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6694-6699

  Bahl, Ash ^a   Barton, Patrick ^a   Bowers, Keith ^a   Caffrey, Moya V ^a   Denton, Rebecca ^a   Gilmour, Peter ^a   Hawley, Shaun ^a   Linannen, Tero ^a   Luckhurst, Christopher A ^a   Mochel, Tobias ^a   Perry, Matthew W D ^a   Riley, Robert J ^a   Roe, Emma ^a   Springthorpe, Brian ^a   Stein, Linda ^a   Webborn, Peter ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Antagonist; Bioavailability; Chemokine

Indexed keywords

AMPHOLYTE; AZ 12436092; BENZOIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CCR3; EOTAXIN 2; PHENYLACETIC ACID DERIVATIVE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANIMAL CELL; DIASTEREOISOMER; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SOLUBILITY; ENANTIOMER; NONHUMAN; RACEMIC MIXTURE; REVIEW;

EID: 84867582813     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.103     Document Type: Article

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