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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6647-6650

Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1

(4) Trippier, Paul C a Benmohammed, Radhia b Kirsch, Donald R b Silverman, Richard B a

a NORTHWESTERN UNIVERSITY (United States)

b Cambria Pharmaceuticals (United States)

Author keywords

Amyotrophic lateral sclerosis; Neuroprotection; Pharmacophore; Pyrazolone; Superoxide dismutase 1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; METHYL GROUP; NITROGEN; PROTON; PYRAZOLONE DERIVATIVE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HYDROGEN BOND; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN AGGREGATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL SURVIVAL; CYCLOPENTANES; DISEASE MODELS, ANIMAL; HUMANS; HYDROGEN BONDING; MICE; MUTATION; PC12 CELLS; PROTEIN FOLDING; PYRAZOLONES; SUPEROXIDE DISMUTASE;

EID: 84867582469 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.08.114 Document Type: Article

Times cited : (14)

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