Phenylpyruvic acid decreases glucose-6-phosphate dehydrogenase activity in rat brain

Cellular and Molecular Neurobiology

Volumn 32, Issue 7, 2012, Pages 1113-1118

  Rosa, Andrea Pereira ^a   Jacques, Carlos Eduardo Dias ^a   Moraes, Tarsila Barros ^a   Wannmacher, Clóvis M D ^a   Dutra, Ângela De Mattos ^b   Dutra Filho, Carlos Severo ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

Author keywords

Glucose 6 phosphate dehydrogenase; Oxidative stress; Phenylacetic acid; Phenylalanine; Phenyllactic acid; Phenylpyruvic acid

Indexed keywords

ATROLACTIC ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PENTOSE PHOSPHATE; PHENYLACETIC ACID; PHENYLALANINE; PHENYLPYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN HOMOGENATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; IN VITRO STUDY; INCUBATION TIME; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PENTOSE PHOSPHATE CYCLE; PHENYLKETONURIA; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; GLUCOSEPHOSPHATE DEHYDROGENASE; PHENYLPYRUVIC ACIDS; RATS; RATS, WISTAR;

RATTUS;

EID: 84867581606     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-012-9834-2     Document Type: Article

References (29)

1. Artuch R, Colome C, Sierra C, Brandi N, Lambruschini N, Campistol J, Ugarte D, Vilaseca MA (2004) A longitudinal study of antioxidant status in phenylketonuric patients. Clin Biochem 37:198-203
2. Biagiotti E, Guidi L, Del Grande P, Ninfali P (2003) Glucose-6- phosphate dehydrogenase expression associated with NADPHdependent reactions in cerebellar neurons. Cerebellum 2:178-183
3. Burgard P (2000) Development of intelligence in early treated phenylketonuria. Eur J Pediatr 159(Suppl 2):S74-S79
4. Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605
5. Cheng ML, Ho HY, Wu YH, Chiu DT (2004) Glucose-6-phosphate dehydrogenase-deficient cells show an increased propensity for oxidant-induced senescence. Free Radic Biol Med 36:580-591
6. Fernandes CG, Leipnitz G, Seminotti B, Amaral AU, Zanatta A, Vargas CR, Dutra Filho CS, Wajner M (2010) Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing rats. Cell Mol Neurobiol 30:317-326
7. Frosali S, Di Simplicio P, Perrone S, Di Giuseppe D, Longini M, Tanganelli D, Buonocore G (2004) Glutathione recycling and antioxidant enzyme activities in erythrocytes of term and preterm newborns at birth. Biol Neonate 85:188-194
8. Hashida K, Sakakura Y, Makino N (2002) Kinetic studies on the hydrogen peroxide elimination by cultured PC12 cells: rate limitation by glucose-6-phosphate dehydrogenase. Biochim Biophys Acta 1572:85-90
9. Hommes FA, Eller RG, Taylor EH (1982) The effects of phenylalanine on myelin metabolism in adolescent rats. In: Cockburn F, Gitzelmann R (eds) Inborn errors of metabolism in human. MTP Press, Lancaster, pp 193-199
10. Kienzle Hagen ME, Pederzolli CD, Sgaravatti AM, Bridi R, Wajner M, Wannmacher CM, Wyse AT, Dutra-Filho CS (2002) Experimental hyperphenylalaninemia provokes oxidative stress in rat brain. Biochim Biophys Acta 1586:344-352
11. Ko CH, Wong RP, Ng PC, Li K, Chui KM, Yuen PM, Fok TF (2009) Oxidative challenge and glucose-6-phosphate dehydrogenase activity of preterm and term neonatal red blood cells. Neonatology 96:96-101
12. Ko CH, Li K, Li CL, Ng PC, Fung KP, James AE, Wong RP, Gu GJ, Fok TF (2011) Development of a novel mouse model of severe glucose-6-phosphate dehydrogenase (G6PD)-deficiency for in vitro and in vivo assessment of hemolytic toxicity to red blood cells. Blood Cells Mol Dis 47:176-181
13. Leong SF, Clark JB (1984) Regional enzyme development in rat brain. Enzymes associated with glucose utilization. Biochem J 218:131-138
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
15. Makino N, Sasaki K, Hashida K, Sakakura Y (2004) A metabolic model describing the H2O2 elimination by mammalian cells including H2O2 permeation through cytoplasmic and peroxisomal membranes: comparison with experimental data. Biochim Biophys Acta 1673:149-159
16. Martinez-Cruz F, Pozo D, Osuna C, Espinar A, Marchante C, Guerrero JM (2002) Oxidative stress induced by phenylketonuria in the rat: prevention by melatonin, vitamin E, and vitamin C. J Neurosci Res 69:550-558
17. Moraes TB, Zanin F, da Rosa A, de Oliveira A, Coelho J, Petrillo F, Wajner M, Dutra-Filho CS (2010) Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain. J Neurol Sci 292:89-95
18. Ribas GS, Sitta A, Wajner M, Vargas CR (2011) Oxidative stress in phenylketonuria: what is the evidence? Cell Mol Neurobiol 31:653-662
19. Salati LM, Amir-Ahmady B (2001) Dietary regulation of expression of glucose-6-phosphate dehydrogenase. Annu Rev Nutr 21:121-140
20. Scriver CR, Kaufman S (2001) Hyperphenylalaninemia: phenylalanine hydroxylase deficiency. In: Scriver CR, Beaudet AL, Sly WS, Walle D (eds) The metabolic and molecular bases of inherited disease, 8th edn. McGraw-Hill, New York, pp 1667-1724
21. Sirtori LR, Dutra-Filho CS, Fitarelli D, Sitta A, Haeser A, Barschak AG, Wajner M, Coelho DM, Llesuy S, Bello-Klein A, Giugliani R, Deon M, Vargas CR (2005) Oxidative stress in patients with phenylketonuria. Biochim Biophys Acta 1740:68-73
22. Sitta A, Barschak AG, Deon M, Terroso T, Pires R, Giugliani R, Dutra-Filho CS, Wajner M, Vargas CR (2006) Investigation of oxidative stress parameters in treated phenylketonuric patients. Metab Brain Dis 21:287-296
23. Sitta A, Barschak AG, Deon M, Barden AT, Biancini GB, Vargas PR, de Souza CF, Netto C, Wajner M, Vargas CR (2009) Effect of short- and long-term exposition to high phenylalanine blood levels on oxidative damage in phenylketonuric patients. Int J Dev Neurosci 27:243-247
24. Tian WN, Pignatare JN, Stanton RC (1994) Signal transduction proteins that associate with the platelet-derived growth factor (PDGF) receptor mediate the PDGF-induced release of glucose- 6-phosphate dehydrogenase from permeabilized cells. J Biol Chem 269:14798-14805
25. Tsai KJ, Hung IJ, Chow CK, Stern A, Chao SS, Chiu DT (1998) Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6-phosphate-dehydrogenase-deficient granulocytes. FEBS Lett 436:411-414
26. Ursini MV, Parrella A, Rosa G, Salzano S, Martini G (1997) Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress. Biochem J 323(Pt 3):801-806
27. Wajner M, Latini A, Wyse AT, Dutra-Filho CS (2004) The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies. J Inherit Metab Dis 27:427-448
28. Weber G (1969) Inhibition of human brain pyruvate kinase and hexokinase by phenylalanine and phenylpyruvate: possible relevance to phenylketonuric brain damage. Proc Natl Acad Sci USA 63:1365-1369
29. Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC (2010) Glucose-6-phosphate dehydrogenasedeficient mice have increased renal oxidative stress and increased albuminuria. FASEB J 24:609-616