Development of a novel mouse model of severe glucose-6-phosphate dehydrogenase (G6PD)-deficiency for in vitro and in vivo assessment of hemolytic toxicity to red blood cells

Blood Cells, Molecules, and Diseases

Volumn 47, Issue 3, 2011, Pages 176-181

  Ko, Chun Hay ^a,b   Li, Karen ^b   Li, Chung Leung ^c   Ng, Pak Cheung ^b   Fung, Kwok Pui ^a   James, Anthony Edward ^a   Wong, Raymond Pui On ^b   Gu, Goldie Jia Shi ^b   Fok, Tai Fai ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

Author keywords

G6PD deficiency; Glutathione; Methemoglobin; Mouse; Oxidative stress

Indexed keywords

1 NAPHTHOL; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; METHEMOGLOBIN; NAPHTHALENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD TOXICITY; CLINICAL ASSESSMENT; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ACTIVITY; DISEASE MODEL; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; GENETIC VARIABILITY; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMATOCRIT; HEMOLYTIC ANEMIA; HOMOZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VALIDATION PROCESS;

ANIMALIA; MUS;

EID: 80053385486     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.07.003     Document Type: Article

References (21)

1. Beutler E., Vulliamy T.J. Hematologically important mutations: glucose-6-phosphate dehydrogenase. Blood Cells Mol Dis. 2002, 28:93-103.
2. Lam S.T., Cheng M.L. Neonatal screening in Hong Kong and Macau. Southeast Asian J Trop Med Public Health. 2003, 34(Suppl 3):73-75.
3. Beutler E. G6PD deficiency. Blood. 1994, 84:3613-3636.
4. Bashan N., Makover O., Livne A., Moses S. Effect of oxidant agents on normal and G6PD-deficient erythrocytes. Isr J Med Sci. 1980, 16:351-356.
5. Wilmanski J., Villanueva E., Deitch E.A., Spolarics Z. Glucose-6-phosphate dehydrogenase deficiency and the inflammatory response to endotoxin and polymicrobial sepsis. Crit Care Med. 2007, 35:510-518.
6. Longo L., Vanegas O.C., Patel M., Rosti V., Li H., Waka J., Merghoub T., Pandolfi P.P., Notaro R., Manova K., Luzzatto L. Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO J. 2002, 21:4229-4239.
7. Pretsch W., Charles D.J., Merkle S. X-linked glucose-6-phosphate dehydrogenase deficiency in Mus musculus. Biochem Genet. 1988, 26:89-103.
8. Pretsch W. Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations. Mamm Genome. 2000, 11:537-542.
9. Ko C.H., Li K., Ng P.C., Fung K.P., Li C.L., Wong R.P., Chui K.M., Gu G.J., Yung E., Wang C.C., Fok T.F. Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro. Int J Mol Med. 2006, 18:987-994.
10. Ko C.H., Yung E., Li K., Li C.L., Ng P.C., Fung K.P., Wong R.P., Chui K.M., Gu G.J., Fok T.F. Multiplex primer extension reaction screening and oxidative challenge of glucose-6-phosphate dehydrogenase mutants in hemizygous and heterozygous subjects. Blood Cells Mol Dis. 2006, 37:21-26.
11. Lin N., Gao X., Li J., Zhu J. Influence of Huanglian and berberine on the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats. Zhongguo Zhong Yao Za Zhi. 1998, 23:562-564.
12. Baader S.L., Schilling M.L., Rosengarten B., Pretsch W., Teutsch H.F., Oberdick J., Schilling K. Purkinje cell lineage and the topographic organization of the cerebellar cortex: a view from X inactivation mosaics. Dev Biol. 1996, 174:393-406.
13. Felix K., Rockwood L.D., Pretsch W., Nair J., Bartsch H., Bornkamm G.W., Janz S. Moderate G6PD deficiency increases mutation rates in the brain of mice. Free Radic Biol Med. 2002, 32:663-673.
14. Pandolfi P.P., Sonati F., Rivi R., Mason P., Grosveld F., Luzzatto L. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 1995, 14:5209-5215.
15. Hutton J.J. Genetic regulation of glucose 6-phosphate dehydrogenase activity in the inbred mouse. Biochem Genet. 1971, 5:315-331.
16. Jain M., Cui L., Brenner D.A., Wang B., Handy D.E., Leopold J.A., Loscalzo J., Apstein C.S., Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation 2004, 109:898-903.
17. Matsui R., Xu S., Maitland K.A., Hayes A., Leopold J.A., Handy D.E., Loscalzo J., Cohen R.A. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005, 112:257-263.
18. Xu Y., Zhang Z., Hu J., Stillman I.E., Leopold J.A., Handy D.E., Loscalzo J., Stanton R.C. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010, 24:609-616.
19. Bloom K.E., Brewer G.J., Magon A.M., Wetterstroem N. Microsomal incubation test of potentially hemolytic drugs for glucose-6-phosphate dehydrogenase deficiency. Clin Pharmacol Ther. 1983, 33:403-409.
20. Bashan N., Peleg N., Moses S.W. Attempts to predict the hemolytic potential of drugs in glucose-6-phosphate dehydrogenase deficiency of the Mediterranean type by an in vitro test. Isr J Med Sci. 1988, 24:61-64.
21. Santucci K., Shah B. Association of naphthalene with acute hemolytic anemia. Acad Emerg Med 2000, 7:42-47.