Open-label, single-arm phase II study of pemetrexed in the treatment of patients with recurrent or metastatic nasopharyngeal carcinoma who have had prior platinum-based chemotherapy

Cancer Chemotherapy and Pharmacology

Volumn 70, Issue 4, 2012, Pages 611-615

  Zhang, Yang ^a,b   Zhao, Liping ^a,b   Huang, Peiyu ^a,b   Wu, Jingxun ^b,c   Wang, Fenghua ^a,b   Huang, Yan ^a,b   Zhang, Li ^a,b  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

Chemotherapy; Metastatic; Nasopharyngeal carcinoma; Pemetrexed

Indexed keywords

CARBOPLATIN; CISPLATIN; CYANOCOBALAMIN; DEXAMETHASONE; DOCETAXEL; FLUOROURACIL; FOLIC ACID; PACLITAXEL; PEMETREXED;

ADULT; AGED; AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANOREXIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE METASTASIS; CANCER REGRESSION; CLINICAL ARTICLE; DRUG ERUPTION; DRUG TOLERABILITY; FATIGUE; FEMALE; FEVER; HUMAN; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; METASTASIS POTENTIAL; MULTIPLE CYCLE TREATMENT; NASOPHARYNX CARCINOMA; NAUSEA AND VOMITING; NEUTROPENIA; OPEN STUDY; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RECURRENT CANCER; SIDE EFFECT; STOMATITIS; THROMBOCYTOPENIA; TREATMENT OUTCOME; TREATMENT RESPONSE; VITAMIN SUPPLEMENTATION;

ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; FEMALE; GLUTAMATES; GUANINE; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PLATINUM COMPOUNDS; SALVAGE THERAPY;

EID: 84867581519     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-012-1950-7     Document Type: Article

References (15)

1. Chan AT, Teo PM, Leung TW, Johnson PJ (1998) The role of chemotherapy in the management of nasopharyngeal carcinoma. Cancer 82:1003-1012
2. Teo PM, Kwan WH, Lee WY et al (1996) Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma. Cancer 77:2423-2431
3. Ma BB, Chan AT (2005) Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma. Cancer 103:22-31
4. Bensouda Y, Kaikani W, Ahbeddou N et al (2011) Treatment for metastatic nasopharyngeal carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis 128:79-85
5. Au E, Tan EH, Ang PT (1998) Activity of paclitaxel by threehour infusion in Asian patients with metastatic undifferentiated nasopharyngeal cancer. Ann Oncol 9:327-329
6. Chua DT, Sham JS, Au GK (2003) A phase II study of capecitabine in patients with recurrent and metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy. Oral Oncol 39:361-366
7. Ciuleanu E, Irimie A, Ciuleanu TE et al (2008) Capecitabine as salvage treatment in relapsed nasopharyngeal carcinoma: a phase II study. J BUON 13:37-42
8. Zhang L, Zhang Y, Huang PY et al (2008) Phase II clinical study of gemcitabine in the treatment of patients with advanced nasopharyngeal carcinoma after the failure of platinum-based chemotherapy. Cancer Chemother Pharmacol 61:33-38
9. Ngeow J, Lim WT, Leong SS et al (2011) Docetaxel is effective in heavily pretreated patients with disseminated nasopharyngeal carcinoma. Ann Oncol 22:718-722
10. Hanna N, Shepherd FA, Fossella FV et al (2004) Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 22:1589-1597
11. Vogelzang NJ, Rusthoven JJ, Symanowski J et al (2003) Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 21:2636-2644
12. Pivot X, Raymond E, Laguerre B et al (2001) Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br J Cancer 85:649-655
13. Poon D, Chowbay B, Cheung YB et al (2005) Phase II study of irinotecan (CPT-11) as salvage therapy for advanced nasopharyngeal carcinoma. Cancer 103:576-581
14. Urba S, van Herpen CM, Sahoo TP et al (2012) Pemetrexed in combination with cisplatin versus cisplatin monotherapy in patients with recurrent or metastatic head and neck cancer: final results of a randomized, double-blind, placebo-controlled, phase 3 study. Cancer. doi:10.1002/cncr.27449
15. Yau TK, Shum T, Lee AW et al (2012) A phase II study of pemetrexed combined with cisplatin in patients with recurrent or metastatic nanopharyngeal carcinoma. Oral Oncol 48:441-444