Vitamin D increases expression of cathelicidin in cultured sebocytes

Archives of Dermatological Research

Volumn 304, Issue 8, 2012, Pages 627-632

  Lee, Weon Ju ^a   Cha, Hyun Wuk ^a   Sohn, Mi Yeung ^a   Lee, Seok Jong ^a   Kim, Do Won ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Antimicrobial peptides; Cathelicidin; Cultured sebocytes; Vitamin D

Indexed keywords

BETA DEFENSIN 2; BETA DEFENSIN 3; CALCITRIOL; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE 18; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; PSORIASIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HAIR FOLLICLE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCALP; SEBACEOUS CELL; SKIN CELL; WESTERN BLOTTING;

ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; PRIMARY CELL CULTURE; RECEPTORS, CALCITRIOL; RNA, SMALL INTERFERING; S100 PROTEINS; SEBACEOUS GLANDS; VITAMIN D;

EID: 84867576731     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-012-1255-z     Document Type: Article

References (29)

1. Broome AM, Ryan D, Eckert RL (2003) S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem 51:675-685
2. Chronnell CM, Ghali LR, Ali RS, Quinn AG, Holland DB, Bull JJ, Cunliffe WJ, McKay IA, Philpott MP, Müller-Röver S (2001) Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. J Invest Dermatol 117:1120-1125
3. Clemens TL, Adams JS, Horiuchi N, Gilchrest BA, Cho H, Tsuchiya Y, Matsuo N, Suda T, Holick MF (1983) Interaction of 1, 25-dihydroxyvitamin-D3 with keratinocytes and fibroblasts from skin of normal subjects and a subject with vitamin-Ddependent rickets, type II: a model for study of the mode of action of 1, 25-dihydroxyvitamin D3. J Clin Endocrinol Metab 56:824-830
4. Dombrowski Y, Peric M, Koglin S, Ruzicka T, Schauber J (2010) Control of cutaneous antimicrobial peptides by vitamin D3. Arch Dermatol Res 302:401-408
5. Froy O (2005) Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways. Cell Microbiol 7:1387-1397
6. Fujie T, Shikiji T, Uchida N, Urano Y, Nagae H, Arase S (1996) Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. Arch Dermatol Res 288:703-708
7. Fukuoka M, Ogino Y, Sato H, Ohta T, Komoriya K, Nishioka K, Katayama I (1998) RANTES expression in psoriatic skin and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin D3 (tacalcitol). Br J Dermatol 138:63-70
8. Gallo RL, Murakami M, Ohtake T, Zaiou M (2002) Biology and clinical relevance of naturally occurring antimicrobial peptides. J Allergy Clin Immunol 110:823-831
9. Ganceviciene R, Fimmel S, Glass E, Zouboulis CC (2006) Psoriasin and follicular hyperkeratinization in acne comedones. Dermatology 213:270-272
10. Gombart AF, Borregaard N, Koeffler HP (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. FASEB J 19:1067-1077
11. Gombart AF, Saito T, Koeffler HP (2009) Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates. BMC Genomics 10:321
12. Graham GM, Farrar MD, Cruse-Sawyer JE, Holland KT, Ingham E (2004) Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br J Dermatol 150:421-428
13. Holick MF (2011) Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets 12:4-18
14. Krämer C, Seltmann H, Seifert M, Tilgen W, Zouboulis CC, Reichrath J (2009) Characterization of the vitamin D endocrine system in human sebocytes in vitro. J Steroid Biochem Mol Biol 113:9-16
15. Lee KC, Eckert RL (2007) S100A7 (Psoriasin)-mechanism of antibacterial action in wounds. J Invest Dermatol 127:945-957
16. Madsen P, Rasmussen HH, Leffers H, Honoré B, Dejgaard K, Olsen E, Kiil J, Walbum E, Andersen AH, Basse B et al (1991) Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J Invest Dermatol 97:701-712
17. Murakami M, Ohtake T, Dorschner RA, Schittek B, Garbe C, Gallo RL (2002) Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J Invest Dermatol 119:1090-1095
18. Nagy I, Pivarcsi A, Kis K, Koreck A, Bodai L, McDowell A, Seltmann H, Patrick S, Zouboulis CC, Kemény L (2006) Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes Infect 8:2195-2205
19. Nagy I, Pivarcsi A, Koreck A, Széll M, Urbán E, Kemény L (2005) Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol 124:931-938
20. Schaller M, Loewenstein M, Borelli C, Jacob K, Vogeser M, Burgdorf WH, Plewig G (2005) Induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with Propionibacterium acnes and coproporphyrin III. Br J Dermatol 153:66-71
21. Schauber J, Iffland K, Frisch S, Kudlich T, Schmausser B, Eck M, Menzel T, Gostner A, Lührs H, Scheppach W (2004) Histonedeacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. Mol Immunol 41:847-854
22. Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL (2008) Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1, 25-Dihydroxyvitamin D (3). J Invest Dermatol 128:816-824
23. Thomas DR (2006) Vitamins in aging, health and longevity. Clin Interv Aging 1:81-91
24. Wang TT, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, Tavera-Mendoza L, Lin R, Hanrahan JW, Mader S, White JH (2004) Cutting edge: 1, 25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173:2909-2912
25. Weber G, Heilborn JD, Chamorro Jimenez CI, Hammarsjo A, Torma H, Stahle M (2005) Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatol 124:1080-1082
26. Webster GF (1999) Acne vulgaris: state of the science. Arch Dermatol 135:1101-1102
27. Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H (2008) Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology 124:357-367
28. Zouboulis CC (2004) Acne and sebaceous gland function. Clin Dermatol 22:360-366
29. Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann C (2008) Human skin stem cells and the ageing process. Exp Gerontol 43:986-997