Effects of copper-loaded chitosan nanoparticles on intestinal microflora and morphology in weaned piglets

Biological Trace Element Research

Volumn 149, Issue 2, 2012, Pages 184-189

  Wang, Min Qi ^a   Du, Yong Jie ^a   Wang, Chao ^a   Tao, Wen Jing ^a   He, Yu Dan ^a   Li, Hui ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Copper loaded chitosan nanoparticles; Intestinal microflora; Intestinal morphology; Weaned piglets

Indexed keywords

CHITOSAN; CHLORTETRACYCLINE; COPPER; COPPER LOADED CHITOSAN NANOPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BACTERIUM DETECTION; BIFIDOBACTERIUM; BODY WEIGHT; CECUM; CONTROLLED STUDY; DECREASED APPETITE; DIARRHEA; DIET SUPPLEMENTATION; DUODENUM; ESCHERICHIA COLI; FOOD INTAKE; GROWTH CURVE; INTESTINE FLORA; JEJUNUM; LACTOBACILLUS; NONHUMAN; PIGLET; SEX DIFFERENCE; TISSUE STRUCTURE; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; CHITOSAN; COPPER; FEMALE; INTESTINES; MALE; NANOPARTICLES; SWINE; WEANING;

BIFIDOBACTERIUM; ESCHERICHIA COLI; LACTOBACILLUS; SUIDAE;

EID: 84867571646     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9410-0     Document Type: Article

References (39)

1. Mathew AG, Sutton AL, Scheidt AB, Patterson JA, Kelly DT, Meyerholtz KA (1993) Effect of galactan on selected microbial populations in the ileum of the weaning pig. J Anim Sci 71:1503-1509
2. Williams NH, Stahly TS, Zimmerman DR (1997) Effects of chronic immune system activation on the rate, efficiency, and composition of growth and lysine needs of pigs fed from 6 to 27 kg. J Anim Sci 75:2463-2471
3. Boudry G, Peron V, Huerou-Luron IL, Lalles JP, Seve B (2004) Weaning induces both transient and long-lasting modifications of absorptive, secretory, and barrier properties of piglet intestine. J Nutr 134:2256-2262
4. Kyriakis SC (1989) The effects of avilamycin in the control of stress-induced post-weaning diarrhoea in piglets. J Vet Pharmacol Ther 12:296-301
5. Bach KK (2001) Development of antibiotic resistance and options to replace antimicrobials in animal diets. Proc Nutr 60:291-299
6. Henrik CW (2003) Antibiotics in animal feed and their role in resistance development. Curr Opin Microbiol 6:439-445
7. Majet NV, Kumar R (2000) A review of chitin and chitosan. React Funct Polym 46:1-27
8. Ramnani SP, Sabharwal S (2006) Adsorption behavior of Cr (VI) onto radiation crosslinked chitosan and its possible application for the treatment of wastewater containing Cr (VI). React Funct Polym 66:902-909
9. Chien PJ, Seu F, Yang FH (2007) Effect of edible chitosan coating on quality and shelf life of sliced mango fruit. J Food Eng 78:225-229
10. Hong KN, Park NY, Lee SH, Meyers SP (2002) Antibacterial activity of chitosan and chitosan oligomers with different molecular weights. J Food Microbiol 74:65-72
11. Tsai GJ, Zhang SL, Shieh PL (2004) Antimicrobial activity of a low-molecular weight chitosan obtained from cellulase digestion of chitosan. J Food Prot 67:396-398
12. Liu N, Chen XG, Park HJ, Liu CG, Liu CS, Meng XH, Yu LJ (2006) Effect of MWand concentration of chitosan on antibacterial activity of Escherichia coli. Carbohydr Polym 64:60-65
13. Du WL, Niu SS, Xu YL, Xu ZR, Fan CL (2009) Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions. Carbohydr Polym 75:385-389
14. Domek MJ, LeChevallier MW, Cameron SC, McFeters GA (1984) Evidence for the role of copper in the injury process of coliform bacteria in drinking water. Appl Environ Microbiol 48:289-293
15. Vasconcelos HL, Favere VT, Goncalves NS, Laranjeira MCM (2007) Chitosan modified with Reactive Blue 2 dye on adsorption equilibrium of Cu (II) and Ni (II) ions. React Funct Polym 67:1052-1060
16. Han XY, Du WL, Fan CL, Xu ZR (2010) Changes in composition a metabolism of caecal microbiota in rats fed diets supplemented with copper-loaded chitosan nanoparticles. J Anim Physiol Anim Nutr 94:138-144
17. 88 of chitosan nanoparticle loaded copper ions. Nanotechnology. doi:10.1088/0957-4484/19/8/085707
18. NRC (1998) Nutrient requirements of swine, 10th edn. National Academies Press, Washington
19. Risley CR, Kornegay ET, Lindemann MD, Wood CM, Eigel WN (1992) Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs. J Anim Sci 70:196-206
20. Bryant MP, Allison I (1961) An improved nonselective culture medium for animal bacterial and its use in determining diurnal variation in numbers of bacteria in the rumen. J Dairy Sci 44:1446-1453
21. Bryant MP (1972) Commentary on the Hungate technique for culture for anaerobic bacteria. Am J Clin Nutr 25:1324-1330
22. Munoa FJ, Pares R (1988) Selective medium for the isolation and enumeration of Bifidobacterium spp. Appl Environ Microbiol 54:1715-1718
23. Holdeman LV, Cato EP, Moore WEC (1977) Anaerobic laboratory manual, 4th edn. Virginia Polytechnic Institute and State University, Blacksburg
24. Hopwood DE, Pethick DW, Pluske JR, Hampson DJ (2004) Addition of pearl barley to a rice-based diet for newly weaned piglets increases the viscosity of the intestinal contents, reduces starch digestibility and exacerbates post-weaning colibacillosis. Br J Nutr 92:419-427
25. Uni Z, Noy Y, Sklan D (1998) Posthatch development of muscosal function in the broiler small intestine. Poult Sci 77:75-82
26. Xu ZR, Hu CH, Xia MS, Zhan XA, Wang MQ (2003) Effects of dietary fructooligosaccharide on digestive enzyme activities, intestinal microflora and morphology of male broilers. Poult Sci 82:1030-1036
27. Xia MS, Hu CH, Xu ZR (2004) Effects of copper-bearing mont-morillonite on growth performance, digestive enzyme activities, and intestinal microflora and morphology of male broilers. J Poult Sci 83:1868-1875
28. Kreuter J (2001) Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47:65-81
29. De Campos AM, Sanchez A, Alonso MJ (2001) Chitosan nano-particles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporine A. Int J Pharm 224:159-168
30. Xu YL, Du Y (2003) Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int J Pharm 250:215-226
31. Domek MJ, Lechevallier MW, Mcfeters GA (1984) Evidence for the role of copper in the injury process of coliforms in drinking water. Appl Environ Microbiol 48:289-293
32. Carcelli M, Mazza P, Pelizzi G (1995) Antimicrobial and geno-toxic activity of 2, 6-diacetylpyridinebis (acylhydrazones) and their complexes with some first transition series metal ions. X-ray crystal structure of a dinuclear copper (II) complex. J Inorg Biochem 57:43-62
33. Jantova S, Labuda L, VollekV ZM (1997) Antimicrobial effects of the macrocyclic Cu (II)-tetraanhydroanimobenzaldehyde complex. Folia Microbiol Prague 42:324-326
34. Tang ZR, Yin YL, Nyachoti CM (2005) Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-mRNA expression in early-weaned piglets. J Domest Anim Endocrinol 28:430-441
35. Hill EG, Larson NL (1955) Effect of chlortetracycline supplementation on growth and feed utilization of unsuckled baby pigs obtained by hysterectomy. J Anim Sci 14:1116-1121
36. Bunch RJ, Speer VC, Hays VW, McCall JT (1963) Effects of high levels of copper and chlortetracycline on performance of pigs. J Anim Sci 22:56-60
37. Collier CT, Smiricky-Tjardes MR, Albin DM, Wubben JE, Gabert VM, Deplancke B, Bane D, Anderson DB, Gaskins HR (2003) Molecular ecological analysis of porcine ileal microbiota responses to antimicrobial growth promoters. J Anim Sci 81:3035-3045
38. Chung YC, Su YP, Chen CC, Jia G, Wang HL, Wu JCG, Lin JG (2004) Relationship between antibacterial activity of chitosan and surface characteristics of cell wall. Acta Pharmacol Sin 25:932-936
39. Fuller R, Newland LGM, Briggs CAE, Braude R, Mitchell KG (1960) The normal intestinal flora of the pig: IV. The effect of dietary supplements of penicillin, chlortetracycline or copper sulphate on the faecal flora. J Appl Microbiol 23:195-205