The association of concurrent vitamin D and sex hormone deficiency with bone loss and fracture risk in older men: The osteoporotic fractures in men (MrOS) study

Journal of Bone and Mineral Research

Volumn 27, Issue 11, 2012, Pages 2306-2313

  Barrett Connor, Elizabeth ^a   Laughlin, Gail A ^a   Li, Hong ^b   Nielson, Carrie M ^b   Wang, P Ying ^b   Dam, Tien T ^a,c   Cauley, Jane A ^d   Ensrud, Kristine E ^e,f   Stefanick, Marcia L ^g   Lau, Edith ^h   Hoffman, Andrew R ^g   Orwoll, Eric S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Hong Kong Orthopaedic and Osteoporosis Center   (Hong Kong)

Author keywords

BONE LOSS; FRACTURE; OLDER MEN; SEX HORMONES; VITAMIN D

Indexed keywords

25 HYDROXYVITAMIN D; ESTRADIOL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGE DISTRIBUTION; AGED; ARTICLE; BONE DENSITY; COMPARATIVE STUDY; DISEASE ASSOCIATION; FRACTURE; HIP; HORMONE DEFICIENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; OSTEOLYSIS; RISK ASSESSMENT; SEDENTARY LIFESTYLE; VITAMIN D DEFICIENCY;

AGED; BONE DENSITY; BONE RESORPTION; COHORT STUDIES; GONADAL STEROID HORMONES; HIP; HUMANS; MALE; OSTEOPOROTIC FRACTURES; RISK FACTORS; VITAMIN D DEFICIENCY;

EID: 84867558111     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1697     Document Type: Article

References (43)

1. Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon PM, Cummings SR, Hoffman AR, Shikany JM, Barrett-Connor E, Orwoll E., Osteoporotic Fractures in Men (MrOS) Research Group. Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2010; 25 (3): 545-53.
2. DeLuca HF., Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80 (6 Suppl): 1689S-96S.
3. Ensrud KE, Lewis CE, Lambert LC, Taylor BC, Fink HA, Barrett-Connor E, Cauley JA, Stefanick ML, Orwoll E., Osteoporotic Fractures in Men MrOS Study Research Group. Endogenous sex steroids, weight change and rates of hip bone loss in older men: the MrOS study. Osteoporos Int. 2006; 17 (9): 1329-36. (Pubitemid 44127319)
4. Roddam AW, Neale R, Appleby P, Allen NE, Tipper S, Key TJ., Association between plasma 25-hydroxyvitamin D levels and fracture risk: the EPIC-Oxford study. Am J Epidemiol. 2007; 166 (11): 1327-36. (Pubitemid 350129418)
5. Looker AC, Mussolino ME., Serum 25-hydroxyvitamin D and hip fracture risk in older U.S. white adults. J Bone Miner Res. 2008; 23 (1): 143-50.
6. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA., The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011; 96 (1): 53-8.
7. Institute of Medicine(IOM). Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; 2011.
8. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V., Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2007; (158): 1-235.
9. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B., Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005; 293 (18): 2257-64. (Pubitemid 40629192)
10. Avenell A, Gillespie WJ, Gillespie LD, O'Connell D., Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev. 2009; (2): CD000227.
11. Khosla S, Melton LJ 3rd, Riggs BL., Clinical review 144: Estrogen and the male skeleton. J Clin Endocrinol Metab. 2002; 87 (4): 1443-50. (Pubitemid 34615219)
12. Khosla S, Melton LJ 3rd, Atkinson EJ, O'Fallon WM., Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab. 2001; 86 (8): 3555-61. (Pubitemid 32755943)
13. Gennari L, Merlotti D, Martini G, Gonnelli S, Franci B, Campagna S, Lucani B, Dal Canto N, Valenti R, Gennari C, Nuti R., Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. J Clin Endocrinol Metab. 2003; 88 (11): 5327-33. (Pubitemid 37452735)
14. Van Pottelbergh I, Goemaere S, Kaufman JM., Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. J Clin Endocrinol Metab. 2003; 88 (7): 3075-81. (Pubitemid 36877475)
15. Cauley JA, Ewing SK, Taylor BC, Fink HA, Ensrud KE, Bauer DC, Barrett-Connor E, Marshall L, Orwoll ES., Osteoporotic Fractures in Men Study (MrOS) Research Group. Sex steroid hormones in older men: longitudinal associations with 4.5-year change in hip bone mineral density-the osteoporotic fractures in men study. J Clin Endocrinol Metab. 2010; 95 (9): 4314-23.
16. Amin S, Zhang Y, Felson DT, Sawin CT, Hannan MT, Wilson PW, Kiel DP., Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med. 2006; 119 (5): 426-33.
17. Barrett-Connor E, Mueller JE, von Muhlen DG, Laughlin GA, Schneider DL, Sartoris DJ., Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2000; 85 (1): 219-23. (Pubitemid 32268817)
18. LeBlanc ES, Nielson CM, Marshall LM, Lapidus JA, Barrett-Connor E, Ensrud KE, Hoffman AR, Laughlin G, Ohlsson C, Orwoll ES., Osteoporotic Fractures in Men Study Group. The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab. 2009; 94 (9): 3337-46.
19. Mellström D, Vandenput L, Mallmin H, Holmberg AH, Lorentzon M, Odén A, Johansson H, Orwoll ES, Labrie F, Karlsson MK, Ljunggren O, Ohlsson C., Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res. 2008; 23 (10): 1552-60.
20. Goderie-Plomp HW, van der Klift M, de Ronde W, Hofman A, de Jong FH, Pols HA., Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study. J Clin Endocrinol Metab. 2004; 89 (7): 3261-9. (Pubitemid 38951891)
21. Meier C, Nguyen TV, Handelsman DJ, Schindler C, Kushnir MM, Rockwood AL, Meikle AW, Center JR, Eisman JA, Seibel MJ., Endogenous sex hormones and incident fracture risk in older men: the Dubbo Osteoporosis Epidemiology Study. Arch Intern Med. 2008; 168 (1): 47-54.
22. Center JR, Nguyen TV, Sambrook PN, Eisman JA., Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab. 1999; 84 (10): 3626-35. (Pubitemid 30645216)
23. Center JR, Nguyen TV, Sambrook PN, Eisman JA., Hormonal and biochemical parameters and osteoporotic fractures in elderly men. J Bone Miner Res. 2000; 15 (7): 1405-11. (Pubitemid 30413875)
24. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR., Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials. 2005; 26 (5): 557-68. (Pubitemid 41242401)
25. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K., Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study-a large observational study of the determinants of fracture in older men. Contemp Clin Trials. 2005; 26 (5): 569-85. (Pubitemid 41242402)
26. Lewis CE, Ewing SK, Taylor BC, Shikany JM, Fink HA, Ensrud KE, Barrett-Connor E, Cummings SR, Orwoll E., Osteoporotic Fractures in Men (MrOS) Study Research Group. Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007; 22 (2): 211-9. (Pubitemid 46167791)
27. Wang X, Sanyal A, Cawthon PM, Palermo L, Jekir M, Christensen J, Ensrud KE, Cummings SR, Orwoll E, Black DM., Osteoporotic Fractures in Men (MrOS) Research Group, Keaveny TM. Prediction of new clinical vertebral fractures in elderly men using finite element analysis of CT scans. J Bone Miner Res. 2012; 27 (4): 808-16.
28. Genant HK, Jergas M., Assessment of prevalent and incident vertebral fractures in osteoporosis research. Osteoporos Int. 2003; 14 (Suppl 3): S43-55.
29. Sanders KM, Pasco JA, Ugoni AM, Nicholson GC, Seeman E, Martin TJ, Skoric B, Panahi S, Kotowicz MA., The exclusion of high trauma fractures may underestimate the prevalence of bone fragility fractures in the community: the Geelong Osteoporosis Study. J Bone Miner Res. 1998; 13 (8): 1337-42. (Pubitemid 28373336)
30. Mackey DC, Lui LY, Cawthon PM, Bauer DC, Nevitt MC, Cauley JA, Hillier TA, Lewis CE, Barrett-Connor E, Cummings SR., Study of Osteoporotic Fractures (SOF) and Osteoporotic Fractures in Men Study (MrOS) Research Groups. High-trauma fractures and low bone mineral density in older women and men. JAMA. 2007; 298 (20): 2381-8.
31. Prentice RL., A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika. 1986; 73: 1-11.
32. Södergård R, Bäckström T, Shanbhag V, Carstensen H., Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem. 1982; 16 (6): 801-10. (Pubitemid 13228095)
33. Singh RJ, Taylor RL, Reddy GS, Grebe SK., C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab. 2006; 91 (8): 3055-61. (Pubitemid 44271755)
34. Holick MF., Vitamin D deficiency. N Engl J Med. 2007; 357 (3): 266-81.
35. Washburn RA, Smith KW, Jette AM, Janney CA., The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol. 1993; 46 (2): 153-62. (Pubitemid 23092124)
36. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D., A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130 (6): 461-70. (Pubitemid 29135798)
37. Block G, Hartman AM, Naughton D., A reduced dietary questionnaire: development and validation. Epidemiology. 1990; 1 (1): 58-64. (Pubitemid 20255624)
38. Orwoll E, Nielson CM, Marshall LM, Lambert L, Holton KF, Hoffman AR, Barrett-Connor E, Shikany JM, Dam T, Cauley JA., Osteoporotic Fractures in Men (MrOS) Study Group. Vitamin D deficiency in older men. J Clin Endocrinol Metab. 2009; 94 (4): 1214-22.
39. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P., Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol. 1994; 10 (4): 405-11. (Pubitemid 24339205)
40. Barlow WE, Ichikawa L, Rosner D, Izumi S., Analysis of case-cohort designs. J Clin Epidemiol. 1999; 52 (12): 1165-72. (Pubitemid 29535416)
41. Lin DY, Wei LJ., The robust inference for the Cox proportional hazards model. J Am Stat Assoc. 1989; 84 (408): 1074-8.
42. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39 (2 Suppl 1): S1-266.
43. Mithal A, Wahl DA, Bonjour JP, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009; 20 (11): 1807-20.