Sex steroid hormones in older men: Longitudinal associations with 4.5-year change in hip bone mineral density - The osteoporotic fractures in men study

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 9, 2010, Pages 4314-4323

  Cauley, Jane A ^a   Ewing, Susan K ^b   Taylor, Brent C ^c   Fink, Howard A ^c   Ensrud, Kristine E ^c   Bauer, Douglas C ^b   Barrett Connor, Elizabeth ^d   Marshall, Lynn ^e   Orwoll, Eric S ^e  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; SEX HORMONE; TESTOSTERONE;

AGED; ARTICLE; BONE DENSITY; CHEMOLUMINESCENCE; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FOLLOW UP; HIP; HUMAN; LIQUID CHROMATOGRAPHY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; UNITED STATES; AGING; BLOOD; CLINICAL TRIAL; COMPLICATION; FRACTURES, BONE; MULTICENTER STUDY; PHYSIOLOGY; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BONE DENSITY; CROSS-SECTIONAL STUDIES; FRACTURES, BONE; GONADAL STEROID HORMONES; HIP; HUMANS; LONGITUDINAL STUDIES; MALE; OSTEOPOROSIS; TIME FACTORS;

EID: 77956565548     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2635     Document Type: Article

References (36)

1. Khosla S, Melton 3rd LJ, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL 1998 Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274
2. Center JR, Nguyen TV, Sambrook PN, Eisman JA 1999 Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 84:3626-3635
3. Szulc P, Hofbauer LC, Heufelder AE, Roth S, Delmas PD 2001 Osteoprotegerin serum levels in men: correlation with age, estrogen, and testosterone status. J Clin Endocrinol Metab 86:3162-3165
4. van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW 2000 Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276-3282
5. Ravaglia G, Forti P, Maioli F, Nesi B, Pratelli L, Cucinotta D, Bastagli L, Cavalli G 2000 Body composition, sex steroids, IGF-1, and bone mineral status in aging men. J Gerontol A Biol Sci Med Sci 55:M516-M521
6. Kelly PJ, Pocock NA, Sambrook PN, Eisman JA 1990 Dietary calcium, sex hormones, and bone mineral density in men. BMJ 300:1361-1364
7. Murphy S, Khaw KT, Cassidy A, Compston JE 1993 Sex hormones and bone mineral density in elderly men. Bone Miner 20:133-140
8. Paller CJ, Shiels MS, Rohrmann S, Basaria S, Rifai N, Nelson W, Platz EA, Dobs A 2009 Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clin Endocrinol (Oxf) 70:26-34
9. Kuchuk NO, van Schoor NM, Pluijm SM, Smit JH, de Ronde W, Lips P 2007 The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. Clin Endocrinol (Oxf) 67:295-303
10. Araujo AB, Travison TG, Leder BZ, McKinlay JB 2008 Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men. J Clin Endocrinol Metab 93:2135-2141
11. Khosla S, Melton 3rd LJ, Atkinson EJ, O'Fallon WM 2001 Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 86:3555-3561
12. Gennari L, Merlotti D, Martini G, Gonnelli S, Franci B, Campagna S, Lucani B, Dal Canto N, Valenti R, Gennari C, Nuti R 2003 Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. J Clin Endocrinol Metab 88:5327-5333
13. Van Pottelbergh I, Goemaere S, Kaufman JM 2003 Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. J Clin Endocrinol Metab 88:3075-3081
14. Bjørnerem A, Emaus N, Berntsen GK, Joakimsen RM, Fønnebø V, Wilsgaard T, Oian P, Seeman E, Straume B 2007 Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromso study. Calcif Tissue Int 81:65-72
15. Khosla S, Melton 3rd LJ, Riggs BL 2002 Clinical review 144: Estrogen and the male skeleton. J Clin Endocrinol Metab 87:1443-1450
16. LeBlanc ES, Nielson CM, Marshall LM, Lapidus JA, Barrett-Connor E, Ensrud KE, Hoffman AR, Laughlin G, Ohlsson C, Orwoll ES 2009 The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men. J Clin Endocrinol Metab 94:3337-3346
17. Kahn SM, Hryb DJ, Nakhla AM, Romas NA, Rosner W 2002 Sex hormone-binding globulin is synthesized in target cells. J Endocrinol 175:113-120
18. Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA 1999 Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate. Steroids 64:100-106
19. Hammes A, Andreassen TK, Spoelgen R, Raila J, Hubner N, Schulz H, Metzger J, Schweigert FJ, Luppa PB, Nykjaer A, Willnow TE 2005 Role of endocytosis in cellular uptake of sex steroids. Cell 122:751-762
20. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K 2005 Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study: a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26:569-585
21. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR 2005 Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials 26:557-568
22. Södergård R, Bäckström T, Shanbhag V, Carstensen H 1982 Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature. J Steroid Biochem 16:801-810
23. Cawthon PM, Ewing SK, McCulloch CE, Ensrud KE, Cauley JA, Cummings SR, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Research Group 2009 Loss of hip BMD in older men: the Osteoporotic Fractures inMen(MrOS) Study. J Bone Miner Res 24:1728-1735
24. Washburn RA, Ficker JL 1999 Physical Activity Scale for the Elderly (PASE): the relationship with activity measured by a portable accelerometer. J Sports Med Phys Fitness 39:336-340
25. Block G, Subar AF 1992 Estimates of nutrient intake from a food frequency questionnaire: the 1987 National Health Interview Survey. J Am Diet Assoc 92:969-977
26. Durrleman S, Simon R 1989 Flexible regression models with cubic splines. Stat Med 8:551-561
27. Devlin TF, Weeks BJ, 1986 Spine functions for logistic regression modeling. Proc Eleventh Annual SAS Users Group International, SAS Institute, Cary, NC, 1986, pp 646-651
28. Turner RT, Wakley GK, Hannon KS 1990 Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats. J Orthop Res 8:612-617
29. Lorentzon M, Swanson C, Andersson N, Mellström D, Ohlsson C 2005 Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study. J Bone Miner Res 20:1334-1341
30. Lapauw BM, Taes Y, Bogaert V, Vanbillemont G, Goemaere S, Zmierczak HG, De Bacquer D, Kaufman JM 2009 Serum estradiol is associated with volumetric BMD and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings. J Bone Miner Res 24:1075-1085
31. Szulc P, Joly-Pharaboz MO, Marchand F, Delmas PD 2004 Insulin-like growth factor I is a determinant of hip bone mineral density in men less than 60 years of age: MINOS study. Calcif Tissue Int 74:322-329
32. Khosla S, Melton 3rd LJ, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, Riggs BL 2005 Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men. J Bone Miner Res 20:730-740 (Pubitemid 40571629)
33. Mellström D, Vandenput L, Mallmin H, Holmberg AH, Lorentzon M, Odén A, Johansson H, Orwoll ES, Labrie F, Karlsson MK, Ljunggren O, Ohlsson C 2008 Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res 23:1552-1560
34. Amin S, Zhang Y, Felson DT, Sawin CT, Hannan MT, Wilson PW, Kiel DP 2006 Estradiol, testosterone, and the risk for hip fractures in elderly men from the Framingham Study. Am J Med 119:426-433
35. Szulc P, Delmas PD 2007 Bone loss in elderly men: increased endosteal bone loss and stable periosteal apposition. The prospective MINOS study. Osteoporos Int 18:495-503
36. Fink HA, Ewing SK, Ensrud KE, Barrett-Connor E, Taylor BC, Cauley JA, Orwoll ES 2006 Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men. J Clin Endocrinol Metab 91:3908-3915