Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats

Histology and Histopathology

Volumn 27, Issue 10, 2012, Pages 1297-1306

  Nakahara, Yutaka ^a   Sano, Tomoya ^a   Kodama, Yasushi ^b   Ozaki, Kiyokazu ^a   Matsuura, Tetsuro ^a  

^a SETSUNAN UNIVERSITY   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Alloxan; Dental caries; Diabetes; F344 rats; Periodontitis

Indexed keywords

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; DENTAL CARIES; EXPERIMENTAL DIABETES MELLITUS; FEMALE; FISCHER 344 RAT; HYPERGLYCEMIA; PATHOLOGY; PERIODONTITIS; RAT;

ALVEOLAR BONE LOSS; ANIMALS; DENTAL CARIES; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; HYPERGLYCEMIA; PERIODONTITIS; RATS; RATS, INBRED F344;

EID: 84867551625     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Belazi M.A., Galli-Tsinopoulou A., Drakoulakos D., Fleva A. and Papanayiotou P.H. (1998). Salivary alterations in insulin-dependent diabetes mellitus. Int. J. Paediatr. Dent. 8, 29-33.
2. Borghelli R.F., Devoto F.C., Foglia V.G. and Erausquin J. (1966). Dental caries in diabetic and prediabetic rats. J. Dent. Res. 45, 1105-1110.
3. Canepari P., Zerman N. and Cavalleri G. (1994). Lack of correlation between salivary Streptococcus mutans and lactobacilli counts and caries in IDDM children. Minerva Stomatol. 43, 501-505.
4. Claudino M., Ceolin D.S., Alberti S., Cestari T.M., Spadella C.T., Rubira-Bullen I.R., Garlet G.P. and de Assis G.F. (2007). Alloxan-induced diabetes triggers the development of periodontal disease in rats. PLoS ONE. 2, e1320.
5. Collin H.L., Uusitupa M., Niskanen L., Koivisto A.M., Markkanen H. and Meurman J.H. (1998). Caries in patients with non-insulin-dependent diabetes mellitus. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 85, 680-685.
6. Hartles R.L. and Lawton F.E. (1958). Experimental dental caries in the albino rat; the effect of single subcutaneous injections of alloxan on the incidence of dental caries. Br. J. Nutr. 12, 286-292.
7. Hintao J., Teanpaisan R., Chongsuvivatwong V., Dahlen G. and Rattarasarn C. (2007). Root surface and coronal caries in adults with type 2 diabetes mellitus. Community Dent. Oral Epidemiol. 35, 302-309.
8. Iughetti L., Marino R., Bertolani M.F. and Bernasconi S. (1999). Oral health in children and adolescents with IDDM--a review. J. Pediatr. Endocrinol. Metab. 12, 603-610.
9. Kodama Y., Matsuura M., Sano T., Nakahara Y., Ozaki K., Narama I. and Matsuura T. (2011). Diabetes enhances dental caries and apical periodontitis in caries-susceptible WBN/KobSlc rats. Comp. Med. 61, 53-59.
10. Lee S.M. and Bressler R. (1981). Prevention of diabetic nephropathy by diet control in the db/db mouse. Diabetes 30, 106-111.
11. Lenzen S. and Panten U. (1988). Alloxan: history and mechanism of action. Diabetologia 31, 337-342.
12. Liu R., Bal H.S., Desta T., Krothapalli N., Alyassi M., Luan Q. and Graves D.T. (2006). Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J. Dent. Res. 85, 510-54.
13. Loe H. (1993). Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 16, 329-334.
14. Mahay S., Adeghate E., Lindley M.Z., Rolph C.E. and Singh J. (2004). Streptozotocin-induced type 1 diabetes mellitus alters the morphology, secretory function and acyl lipid contents in the isolated rat parotid salivary gland. Mol. Cell. Biochem. 261, 175-181.
15. Malaisse W.J., Malaisse-Lagae F., Sener A. and Pipeleers D.G. (1982). Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc. Natl. Acad. Sci. USA 79, 927-930.
16. Mata A.D., Marques D., Rocha S., Francisco H., Santos C., Mesquita M.F. and Singh J. (2004). Effects of diabetes mellitus on salivary secretion and its composition in the human. Mol. Cell. Biochem. 261, 137-142.
17. McNamara T.F., Ramamurthy N.S., Mulvihill J.E. and Golub L.M. (1982). The development of an altered gingival crevicular microflora in the alloxan-diabetic rat. Arch. Oral Biol. 27, 217-223.
18. Mealey B.L. and Oates T.W. (2006). Diabetes mellitus and periodontal diseases. J. Periodontol. 77, 1289-1303.
19. Miralles L., Silvestre F.J., Hernandez-Mijares A., Bautista D., Llambes F. and Grau D. (2006). Dental caries in type 1 diabetics: influence of systemic factors of the disease upon the development of dental caries. Med. Oral Patol. Oral Cir. Bucal. 11, E256-60.
20. Moore P.A., Guggenheimer J., Etzel K.R., Weyant R.J. and Orchard T. (2001). Type 1 diabetes mellitus, xerostomia, and salivary flow rates. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 92, 281-291.
21. Nagy A., Nagashima H., Cha S., Oxford G.E., Zelles T., Peck A.B. and Humphreys-Beher M.G. (2001). Reduced oral wound healing in the NOD mouse model for type 1 autoimmune diabetes and its reversal by epidermal growth factor supplementation. Diabetes 50, 2100-2104.
22. Nichols M.S. and Shaw J.H. (1957). The effect of alloxan diabetes on caries incidence in the albino rat. J. Dent. Res. 36, 68-74.
23. Pontes Andersen C.C., Buschard K., Flyvbjerg A., Stoltze K. and Holmstrup P. (2006). Periodontitis deteriorates metabolic control in type 2 diabetic Goto-Kakizaki rats. J. Periodontol. 77, 350-356.
24. Ryan M.E., Carnu O. and Kamer A. (2003). The influence of diabetes on the periodontal tissues. J. Am. Dent. Assoc. 134 Spec No, 34S-40S.
25. Saadoun A.P. (1980). Diabetes and periodontal disease: a review and update. J. West Soc. Periodontol. Periodontal. Abstr. 28, 116-139.
26. Sano T., Ozaki K., Kodama Y., Matsuura T. and Narama I. (2009). Effects of the antifungal agent itraconazole on proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats. Toxicol. Pathol. 37, 790-798.
27. Sano T., Matsuura T., Ozaki K. and Narama I. (2011). Dental caries and caries-related periodontitis in type 2 diabetic mice. Vet. Pathol. 48, 506-512.
28. Taylor G.W., Manz M.C. and Borgnakke W.S. (2004). Diabetes, periodontal diseases, dental caries, and tooth loss: a review of the literature. Compend. Contin. Educ. Dent. 25, 179-84, 186-8, 190; quiz 192.
29. Tesseromatis C., Kotsiou A., Parara H., Vairaktaris E. and Tsamouri M. (2009). Morphological changes of gingiva in streptozotocin diabetic rats. Int. J. Dent. 2009, 725628.
30. Twetman S., Johansson I., Birkhed D. and Nederfors T. (2002). Caries incidence in young type 1 diabetes mellitus patients in relation to metabolic control and caries-associated risk factors. Caries Res. 36, 31-35.
31. Watanabe D., Nakara H., Yamaguchi Y., Akagi K., Hoshiya T., Nagashima Y., Okaniwa A. and Yoshikawa H. (2004). The pathological features of alloxan diabetes in beagle dogs. J. Toxicol. Pathol. 17, 187-195.