Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation

Diabetes

Volumn 50, Issue 9, 2001, Pages 2100-2104

  Nagy, Akos ^a   Nagashima, Hiroyuki ^b   Cha, Seunghee ^b   Oxford, Gregory E ^b   Zelles, Tivadar ^a   Peck, Ammon B ^c   Humphreys Beher, Michael G ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b UNIVERSITY OF FLORIDA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; MESSENGER RNA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BODY WEIGHT; DRUG EFFECT; FEMALE; GENETICS; HOMEOSTASIS; INJURY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TONGUE; WOUND HEALING;

ANIMALS; BODY WEIGHT; DIABETES MELLITUS, TYPE 1; EPIDERMAL GROWTH FACTOR; FEMALE; HOMEOSTASIS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; ORGAN SIZE; RNA, MESSENGER; TONGUE; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0035461854     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.9.2100     Document Type: Article

References (39)

1. Herrera JL, Lyons MF, Johnson LF: Saliva: its role in health and disease. J Clin Gastroenterol 10:569-578, 1988
2. Fox PC: Saliva composition and its importance in dental health. Compend Suppl 13:S457-S460, 1989
3. Zelles T, Purushotham KR, Macauley SP, Oxford GE, Humpreys-Beher MG: Saliva and growth factors: the fountain of youth resides in us all. J Dent Res 74:1826-1832, 1995
4. Gubits RM, Shaw PA, Gresik EW, Onetti-Muda A, Barka T: Epidermal growth expression is regulated differently in mouse kidney and submandibular gland. Endocrinology 119:1382-1387, 1986
5. Watson AY, Anderson JK, Siminoski K, Mole SE, Murphy RA: Cellular and subcellular colocalization of nerve growth factor and epidermal growth factor in mouse submandibular glands. Anat Rec 213:365-376, 1985
6. Yeh Y-C, Guh S-Y, Yeh J, Yeh H-W: Transforming growth factor type alpha in normal human adult saliva. Molec Cell Endocrinol 67:247-255, 1989
7. Humphreys-Beher MG, Macauley SP, Chegini N, van Setten G, Punishotham KR, Stewart C, Schultz GS: Characterization of the synthesis and secretion of transforming growth factor alpha from salivary glands and saliva. Endocrinology 134:963-970, 1994
8. Smith PH, Patel DG: Immunochemical studies of the insulin-like material in the parotid gland of rats. Diabetes 33:661-666, 1984
9. Costigan DC, Guyda HJ, Posner B: Free insulin-like growth factor I (IGF-I) and IGF-II in human saliva. J Clin Endocrinol 66:1014-1018, 1988
10. Kerr M, Lee A, Wang PL, Purushotham KR, Chegini N, Yamamoto H, Humphreys-Beher MG: Detection of insulin, insulin like growth factors I and II in saliva and potential synthesis in the salivary glands of mice. Effect of type 1 diabetes mellitus. Biochem Pharmacol 49:1521-1531, 1995
11. Murikami K, Taniquchi H, Baba S: Presence of insulin-like immunoreactivity and its biosynthesis in rat and human parotid gland. Diabetolgia 22:358-361, 1982
12. Ryan J, Mantle T, McQuaid CJ, Costigan DC: Salivary insulin-like growth factor originates from local synthesis. J Endocrinol 135:85-90, 1992
13. Hiramatsu Y, Kagami H, Kosaki K, Sigetomi T, Ueda M, Kobayashi S, Sakanaka M: The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands. Nagoya J Med Sci 57:143-152, 1994
14. Cohen S: Isolation of a mouse submaxillary protein accelerating incisor eruption and eyelid opening in the newborn animal. J Biol Chem 237:1555-1562, 1962
15. Niall M, Ryan GB, O'Brien BM: The effect of epidermal growth factor on wound healing in mice. J Surg Res 33:164-169, 1982
16. Rail LB, Scott J, Bell GI, Crawford RJ, Penschow JD, Naill HD, Coghlan RD: Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature 313:228-231, 1985
17. Noguchi S, Ohba Y, Oka T: Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice. J Endocrinol 128:425-431, 1991
18. Olsen PS, Poulsen SS, Kirkegaard P, Nexo E: Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 87:103-108, 1984
19. Konturek SJ, Dembinski A, Warzecha Z, Brzozowski T, Gregory H: Role of epidermal growth actor in healing of chronic gastrointestinal ulcers in rats. Gastroenterology 94:1300-1307, 1988
20. Schneyer CA, Humphreys-Beher MG: Effects of epidermal growth factor and nerve growth factor for isoproterenol induced DNA synthesis in rat parotid and pancreas following removal of the submandibular/sublingual glands. J Oral Pathol 17:350-356, 1988
21. Tsutsumi O, Kurachi H, Oka T: A physiological role of epidermal growth factor in male, reproductive system. Science 233:975-977, 1986
22. Kurachi H, Oka T: Changes in epidermal growth factor concentrations of submandibular gland, plasma, and urine of normal and sialoadenectomized female mice during various reproductive states. J Endocrinol 106:197-202, 1985
23. Tsutsumi O, Taketani Y, Oka T: The uterine growth promoting action of epidermal growth factor and its function in the fertility of mice. J Endocrinol 138:437-444, 1993
24. Massagué J: Epidermal growth factor like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem 258:13614-13620, 1983
25. Noguchi S, Ohba Y, Oka T: Effect of salivary epidermal growth factor on wound healing of tongue in mice. Am J Physiol 260:E620-E625, 1991
26. Kasayama S, Oka T: Impaired production of nerve growth factor in the submandibular gland of diabetic mice. Am J Physiol 257:E400-E404, 1989
27. Serrero G, Lepak NM, Hayashi J, Goodrich SP: Impaired epidermal growth factor production in genetically obese ob/ob mice. Am J Physiol 264:E800-E803, 1993
28. Hu Y, Nakagawa Y, Purushotham KR, Humphreys-Beher MG: Functional changes in salivary glands of autoimmune disease-prone NOD mice. Am J Physiol 263:E607-E614, 1992
29. Knighton DR, Fiegel VD: Growth factors and comprehensive surgical care of diabetic wounds. Curr Opin Gen Surg 1:32-39, 1993
30. Oxford GE, Tayari L, Barfoot MD, Peck AB, Tanaka Y, Humphreys-Beher MG: Salivary EGF levels reduced in diabetic patients. J Diabetes Complications 14:140-145, 2000
31. Robinson CP, Cornelius J, Bounous DI, Yamamoto H, Humphreys-Beher MG, Peck AB: Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice. Autoimmunity 27:29-44, 1998
32. Humphreys-Beher MG, Hu Y, Wang P-L, Purushotham KR: Utilization of the NOD mouse as an animal model for the study of secondary Sjögren's syndrome. Adv Exp Med Biol 350:631-636, 1994
33. Levi-Montalcini R, Cohen S: Effects of the mouse submaxillary glands on the sympathetic system in mammals. Ann N Y Acad Sci 85:324-341, 1960
34. Carpenter G, Cohen S: Epidermal growth factor. Annu Rev Biochem 48:193-216, 1979
35. Brown RL, Breeden MP, Greenhalgh DG: PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res 56:562-70, 1994
36. Anderson LC, Johnson DA: Effects of alloxan diabetes on rat parotid gland and saliva. Comp Biochem Physiol 70B:725-730, 1984
37. Maeda N, Nakagawa Y, Sakia M, Uno K, Takahashi A, Fujita H, Ishibashi K, Humphreys-Beher MG: Streptozotocin induced dry mouth in ICR mice. In Sjögren's Syndrome - State of the Art. Homma M, Sugia S, Tojo T, Miyasaka N, Akizuki M, Eds. Amsterdam, Kugler Publications, 1993, p. 513-518
38. Morris-Wiman J, Sego R, Brinkley L, Dolce C: The effects of sialoadenectomy and exogenous EGF on taste bud morphology and maintenance. Chem Senses 25:9-19, 2000
39. Pessa ME, Bland KI, Copeland ED III: Growth factors and determinants of wound healing. J Surg Res 42:207-217, 1987