Relationship between total bilirubin and endothelial function, inflammation and oxidative stress in HIV-infected adults on stable antiretroviral therapy

HIV Medicine

Volumn 13, Issue 10, 2012, Pages 609-616

  Hileman, C O ^a,b   Longenecker, C T ^b,c   Carman, T L ^b,c   Milne, G L ^d   Labbato, D E ^b,c   Storer, N J ^b,c   White, C A ^c   McComsey, G A ^b,c  

^a METROHEALTH MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Endothelial function; HIV infection; Inflammation; Total bilirubin

Indexed keywords

ATAZANAVIR; BILIRUBIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CELL ADHESION MOLECULE; D DIMER; FIBRINOGEN; INSULIN; INTERLEUKIN 6; ISOPROSTANE DERIVATIVE; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; ARTICLE; BLOOD FLOW; BRACHIAL ARTERY; CONTROLLED STUDY; CORRELATION COEFFICIENT; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; INSULIN RESISTANCE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; VASCULAR ENDOTHELIUM;

ADULT; BILIRUBIN; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; C-REACTIVE PROTEIN; CELL ADHESION MOLECULES; CROSS-SECTIONAL STUDIES; ENDOTHELIUM, VASCULAR; F2-ISOPROSTANES; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HIV PROTEASE INHIBITORS; HIV SEROPOSITIVITY; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; MIDDLE AGED; OLIGOPEPTIDES; OXIDATIVE STRESS; PYRIDINES; RETROSPECTIVE STUDIES; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION;

EID: 84867548863     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2012.01026.x     Document Type: Article

References (20)

1. Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129-2138.
2. Ross AC, Rizk N, O'Riordan MA etal. Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy. Clin Infect Dis 2009; 49: 1119-1127.
3. Phillips AN, Carr A, Neuhaus J etal. Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trial. Antivir Ther 2008; 13: 177-187.
4. Kawamura K, Ishikawa K, Wada Y etal. Bilirubin from heme oxygenase-1 attenuates vascular endothelial activation and dysfunction. Arterioscler Thromb Vasc Biol 2005; 25: 155-160.
5. Keshavan P, Deem TL, Schwemberger SJ, Babcock GF, Cook-Mills JM, Zucker SD. Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration. J Immunol 2005; 174: 3709-3718.
6. Erdogan D, Gullu H, Yildirim E etal. Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima- media thickness in both men and women. Atherosclerosis 2006; 184: 431-437.
7. Djousse L, Levy D, Cupples LA, Evans JC, D'Agostino RB, Ellison RC. Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol 2001; 87: 1196-1200.
8. Perlstein TS, Pande RL, Creager MA, Weuve J, Beckman JA. Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004. Am J Med 2008; 121: 781-788.
9. Perlstein TS, Pande RL, Beckman JA, Creager MA. Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arterioscler Thromb Vasc Biol 2008; 28: 166-172.
10. Lin JP, O'Donnell CJ, Schwaiger JP etal. Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study. Circulation 2006; 114: 1476-1481.
11. Dekker D, Dorresteijn MJ, Pijnenburg M etal. The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 2011; 31: 458-463.
12. Dube MP, Shen C, Greenwald M, Mather KJ. No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo- controlled trial. Clin Infect Dis 2008; 47: 567-574.
13. Flammer AJ, Vo NT, Ledergerber B etal. Effect of atazanavir versus other protease inhibitor-containing antiretroviral therapy on endothelial function in HIV-infected persons: randomised controlled trial. Heart 2009; 95: 385-390.
14. Murphy RL, Berzins B, Zala C etal. Change to atazanavir/ritonavir treatment improves lipids but not endothelial function in patients on stable antiretroviral therapy. AIDS 2010; 24: 885-890.
15. Corretti MC, Anderson TJ, Benjamin EJ etal. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-265.
16. Hileman CO, Carman TL, Storer NJ, Labbato DE, White CA, McComsey GA. Omega-3 Fatty Acids Do Not Improve Endothelial Function In Virologically Suppressed HIV-Infected Men: a Randomized Placebo-Controlled Trial. AIDS Res Hum Retroviruses 2011 [Epub ahead of print].
17. Celermajer DS, Sorensen KE, Gooch VM etal. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-1115.
18. Torriani FJ, Komarow L, Parker RA etal. Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: the ACTG (AIDS Clinical Trials Group) Study 5152s. J Am Coll Cardiol 2008; 52: 569-576.
19. Regidor DL, Detels R, Breen EC etal. Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation. AIDS 2011; 25: 303-314.
20. Mondal D, Pradhan L, Ali M, Agrawal KC. HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants. Cardiovasc Toxicol 2004; 4: 287-302.