GM1 cluster mediates formation of toxic Aβ fibrils by providing hydrophobic environments

Biochemistry

Volumn 51, Issue 41, 2012, Pages 8125-8131

  Fukunaga, Saori ^a   Ueno, Hiroshi ^a   Yamaguchi, Takahiro ^a   Yano, Yoshiaki ^a   Hoshino, Masaru ^a   Matsuzaki, Katsumi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,4-DIOXANE; ALZHEIMER; AMYLOID FIBRIL; CYTOTOXIC; FIBRIL FORMATION; HUMAN NEUROBLASTOMA; HYDROPHOBIC ENVIRONMENT; INCUBATION TIME; LIPID-PROTEIN INTERACTIONS; POLAR ENVIRONMENTS; SHEET STRUCTURE; SOLVENT CONDITIONS; SURFACE HYDROPHOBICITY;

AGGREGATES; CYTOTOXICITY; ETHERS; GLYCOPROTEINS; HYDROPHOBICITY; MEMBRANES;

PROTEINS;

7 DIETHYLAMINOCOUMARIN 3 CARBONYL DYE; AMYLOID; AMYLOID BETA PROTEIN[1-40]; AMYLOID D; AMYLOID M; AMYLOID W; DIOXANE; DYE; GANGLIOSIDE GM1; UNCLASSIFIED DRUG; WATER;

ARTICLE; BETA SHEET; CELL MEMBRANE; CELL POLARITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFRARED SPECTROSCOPY; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; RAFTLIKE MEMBRANE; STATIC ELECTRICITY;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; G(M1) GANGLIOSIDE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS;

EID: 84867533254     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300839u     Document Type: Article

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