Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging

Journal of Applied Physiology

Volumn 113, Issue 8, 2012, Pages 1201-1212

  Casey, Darren P ^a,b   Joyner, Michael J ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

adrenergic receptors; Aging; Muscle contraction; Vasodilation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; PHENTOLAMINE;

ADRENERGIC SYSTEM; ADULT; AGED; AGING; ARTICLE; BLOOD FLOW; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRACHIAL ARTERY; DRUG EFFECT; FEMALE; FOREARM; HEART RATE; HEMODYNAMICS; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; LOWER BODY NEGATIVE PRESSURE; MALE; METHODOLOGY; MUSCLE CONTRACTION; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION; VASOCONSTRICTION; VASODILATATION;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; AGED; AGING; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRACHIAL ARTERY; FEMALE; FOREARM; HEART RATE; HEMODYNAMICS; HUMANS; INFUSIONS, INTRA-ARTERIAL; LOWER BODY NEGATIVE PRESSURE; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PHENTOLAMINE; REGIONAL BLOOD FLOW; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASODILATION;

EID: 84867518777     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00734.2012     Document Type: Article

References (52)

1. Bearden SE. Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction. Am J Physiol Regul Integr Comp Physiol 293: R1274-R1279, 2007.
2. Bearden SE, Payne GW, Chisty A, Segal SS. Arteriolar network architecture and vasomotor function with ageing in mouse gluteus maximus muscle. J Physiol 561: 535-545, 2004.
3. Behnke BJ, Delp MD. Aging blunts the dynamics of vasodilation in isolated skeletal muscle resistance vessels. J Appl Physiol 108: 14-20, 2010.
4. Brock RW, Tschakovsky ME, Shoemaker JK, Halliwill JR, Joyner MJ, Hughson RL. Effects of acetylcholine and nitric oxide on forearm blood flow at rest and after a single muscle contraction. J Appl Physiol 85: 2249-2254, 1998.
5. Carlson RE, Kirby BS, Voyles WF, Dinenno FA. Evidence for impaired skeletal muscle contraction-induced rapid vasodilation in aging humans. Am J Physiol Heart Circ Physiol 294: H1963-H1970, 2008.
6. Clifford PS, Hellsten Y. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97: 393-403, 2004.
7. Convertino VA, Doerr DF, Ludwig DA, Vernikos J. Effect of simulated microgravity on cardiopulmonary baroreflex control of forearm vascular resistance. Am J Physiol Regul Integr Comp Physiol 266: R1962-R1969, 1994.
8. Copp SW, Ferreira LF, Herspring KF, Musch TI, Poole DC. The effects of aging on capillary hemodynamics in contracting rat spinotrapezius muscle. Microvasc Res 77: 113-119, 2009.
9. Corcondilas A, Koroxenidis GT, Shepherd JT. Effect of a brief contraction of forearm muscles on forearm blood flow. J Appl Physiol 19: 142-146, 1964.
10. Davy KP, Seals DR, Tanaka H. Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age. Hypertension 32: 298-304, 1998.
11. DeLorey DS, Wang SS, Shoemaker JK. Evidence for sympatholysis at the onset of forearm exercise. J Appl Physiol 93: 555-560, 2002.
12. Dietz NM, Rivera JM, Eggener SE, Fix RT, Warner DO, Joyner MJ. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol 480: 361-368, 1994.
13. Dinenno FA, Dietz NM, Joyner MJ. Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men. Circulation 106: 1349-1354, 2002.
14. Dinenno FA, Masuki S, Joyner MJ. Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men. J Physiol 567: 311-321, 2005.
15. Donato AJ, Uberoi A, Wray DW, Nishiyama S, Lawrenson L, Richardson RS. Differential effects of aging on limb blood flow in humans. Am J Physiol Heart Circ Physiol 290: H272-H278, 2006.
16. Eklund B, Kaijser L. Effect of regional α- and β-adrenergic blockade on blood flow in the resting forearm during contralateral isometric handgrip. J Physiol 262: 39-50, 1976.
17. Engelke KA, Halliwill JR, Proctor DN, Dietz NM, Joyner MJ. Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm. J Appl Physiol 81: 1807-1814, 1996.
18. Hachiya T, Hashimoto I, Saito M, Blaber AP. Peripheral vascular responses of men and women to LBNP. Aviat Space Environ Med 83: 118-124, 2012.
19. Hammer LW, Boegehold MA. Functional hyperemia is reduced in skeletal muscle of aged rats. Microcirculation 12: 517-526, 2005.
20. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J, Joyner MJ. Sex and ageing differences in resting arterial pressure regulation: the role of the -adrenergic receptors. J Physiol 589: 5285-5297, 2011.
21. Hirai DM, Copp SW, Hageman KS, Poole DC, Musch TI. Aging alters the contribution of nitric oxide to regional muscle hemodynamic control at rest and during exercise in rats. J Appl Physiol 111: 989-998, 2011.
22. Hogikyan RV, Supiano MA. Arterial α-adrenergic responsiveness is decreased and SNS activity is increased in older humans. Am J Physiol Endocrinol Metab 266: E717-E724, 1994.
23. Holloszy JO, Kohrt WM. Exercise. In: Handbook of Physiology. Aging. Bethesda, MD: Am. Physiol. Soc., 1995, sect. 11, chapt. 24, p. 633-666.
24. Jackson DN, Moore AW, Segal SS. Blunting of rapid onset vasodilatation and blood flow restriction in arterioles of exercising skeletal muscle with ageing in male mice. J Physiol 588: 2269-2282, 2010.
25. Joyner MJ, Charkoudian N, Wallin BG. Sympathetic nervous system and blood pressure in humans: individualized patterns of regulation and their implications. Hypertension 56: 10-16, 2010.
26. Kirby BS, Voyles WF, Simpson CB, Carlson RE, Schrage WG, Dinenno FA. Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration. J Physiol 587: 1989-2003, 2009.
27. Kneale BJ, Chowienczyk PJ, Brett SE, Coltart DJ, Ritter JM. Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculature. J Am Coll Cardiol 36: 1233-1238, 2000.
28. Lawrenson L, Hoff J, Richardson RS. Aging attenuates vascular and metabolic plasticity but does not limit improvement in muscleV̇O2 max. Am J Physiol Heart Circ Physiol 286: H1565-H1572, 2004.
29. Lawrenson L, Poole JG, Kim J, Brown C, Patel P, Richardson RS. Vascular and metabolic response to isolated small muscle mass exercise: effect of age. Am J Physiol Heart Circ Physiol 285: H1023-H1031, 2003.
30. Limberg JK, Eldridge MW, Proctor LT, Sebranek JJ, Schrage WG. α-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase. J Appl Physiol 109: 1360-1368, 2010.
31. Lott ME, Hogeman C, Herr M, Bhagat M, Sinoway LI. Sex differences in limb vasoconstriction responses to increases in transmural pressures. Am J Physiol Heart Circ Physiol 296: H186-H194, 2009.
32. Matthews JN, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. Br Med J 300: 230-235, 1990.
33. Minson CT, Halliwill JR, Young TM, Joyner MJ. Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101: 862-868, 2000.
34. Miyachi M, Tanaka H, Kawano H, Okajima M, Tabata I. Lack of age-related decreases in basal whole leg blood flow in resistance-trained men. J Appl Physiol 99: 1384-1390, 2005.
35. Musch TI, Eklund KE, Hageman KS, Poole DC. Altered regional blood flow responses to submaximal exercise in older rats. J Appl Physiol 96: 81-88, 2004.
36. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 45: 522-525, 2005.
37. Padilla J, Young CN, Simmons GH, Deo SH, Newcomer SC, Sullivan JP, Laughlin MH, Fadel PJ. Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns. Am J Physiol Heart Circ Physiol 298: H1128-H1135, 2010.
38. Parker BA, Smithmyer SL, Jarvis SS, Ridout SJ, Pawelczyk JA, Proctor DN. Evidence for reduced sympatholysis in leg resistance vasculature of healthy older women. Am J Physiol Heart Circ Physiol 292: H1148-H1156, 2007.
39. Patterson GC, Shepherd JT. The effects of continuous infusions into the brachial artery of adenosine triphosphate, histamine and acetylcholine on the amount and rate of blood debt repayment following rhythmic exercise of the forearm muscles. Clin Sci (Lond) 13: 85-91, 1954.
40. Poole JG, Lawrenson L, Kim J, Brown C, Richardson RS. Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. Am J Physiol Heart Circ Physiol 284: H1251-H1259, 2003.
41. Proctor DN, Joyner MJ. Skeletal muscle mass and the reduction of V̇O2 max in trained older subjects. J Appl Physiol 82: 1411-1415, 1997.
42. Proctor DN, Koch DW, Newcomer SC, Le KU, Leuenberger UA. Impaired leg vasodilation during dynamic exercise in healthy older women. J Appl Physiol 95: 1963-1970, 2003.
43. Proctor DN, Parker BA. Vasodilation and vascular control in contracting muscle of the aging human. Microcirculation 13: 315-327, 2006.
44. Proctor DN, Shen PH, Dietz NM, Eickhoff TJ, Lawler LA, Ebersold EJ, Loeffler DL, Joyner MJ. Reduced leg blood flow during dynamic exercise in older endurance-trained men. J Appl Physiol 85: 68-75, 1998.
45. Rea RF, Wallin BG. Sympathetic nerve activity in arm and leg muscles during lower body negative pressure in humans. J Appl Physiol 66: 2778-2781, 1989.
46. Schrage WG, Eisenach JH, Joyner MJ. Ageing reduces nitric-oxideand prostaglandin-mediated vasodilatation in exercising humans. J Physiol 579: 227-236, 2007.
47. Short KR, Nair KS. Muscle protein metabolism and the sarcopenia of aging. Int J Sport Nutr Exerc Metab Suppl 11: S119-S127, 2001.
48. Sundlof G, Wallin BG. Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J Physiol 274: 621-637, 1978.
49. Tschakovsky ME, Hughson RL. Rapid blunting of sympathetic vasoconstriction in the human forearm at the onset of exercise. J Appl Physiol 94: 1785-1792, 2003.
50. Tschakovsky ME, Rogers AM, Pyke KE, Saunders NR, Glenn N, Lee SJ, Weissgerber T, Dwyer EM. Immediate exercise hyperemia in humans is contraction intensity dependent: evidence for rapid vasodilation. J Appl Physiol 96: 639-644, 2004.
51. Wilkins BW, Pike TL, Martin EA, Curry TB, Ceridon ML, Joyner MJ. Exercise intensity-dependent contribution of -adrenergic receptormediated vasodilatation in hypoxic humans. J Physiol 586: 1195-1205, 2008.
52. Wray DW, Nishiyama SK, Richardson RS. Role of α1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age. Am J Physiol Heart Circ Physiol 296: H497-H504, 2009.