Effect of the rd1 mutation on motor performance in R6/2 and wild type mice

PLoS Currents

Volumn , Issue , 2012, Pages

  Menalled, Liliana ^a   El Khodor, Bassem F ^b   Hornberger, Monica ^a   Park, Larry ^c   Howland, David ^c   Brunner, Dani ^a  

^a PSYCHOGENICS INC   (United States)

^b PFIZER INC   (United States)

^c CHDI MANAGEMENT CHDI FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE; GENE MUTATION; GRIP STRENGTH; HETEROZYGOSITY; HOMOZYGOSITY; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NERVE DEGENERATION; NONHUMAN; OPEN FIELD TEST; PHENOTYPE; RD1 GENE; ROTAROD TEST; SURVIVAL; WILD TYPE; HUNTINGTON CHOREA; LIFESPAN; OPEN FIELD BEHAVIOR; R6/2 MOUSE; REAL TIME POLYMERASE CHAIN REACTION; RETINAL DEGENERATION 1 GENE; TRANSGENIC MOUSE; BEHAVIOR; COGNITION; GENOTYPE; HYPERACTIVITY; PERFORMANCE; RETINA DEGENERATION;

EID: 84867507467     PISSN: None     EISSN: 21573999     Source Type: Journal    
DOI: 10.1371/currents.RRN1303     Document Type: Article

References (9)

1. Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 1990 Oct 18;347(6294):677-80. PubMed PMID: 1977087.
2. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci. 1978 Jun;17(6):489-98. PubMed PMID: 659071.
3. Clapcote SJ, Lazar NL, Bechard AR, Roder JC. Effects of the rd1 mutation and host strain on hippocampal learning in mice. Behav Genet. 2005 Sep;35(5):591-601. PubMed PMID: 16184487.
4. Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell. 1996 Nov 1;87(3):493-506. PubMed PMID: 8898202.
5. Alvarez-López C, Cernuda-Cernuda R, García-Fernández JM. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res. 2006 May 4;1087(1):134-41. Epub 2006 Apr 13. PubMed PMID: 16626665.
6. Azadi S, Johnson LE, Paquet-Durand F, Perez MT, Zhang Y, Ekström PA, van Veen T. CNTF+BDNF treatment and neuroprotective pathways in the rd1 mouse retina. Brain Res. 2007 Jan 19;1129(1):116-29. Epub 2006 Dec 6. PubMed PMID: 17156753.
7. Cepeda C, Starling AJ, Wu N, Nguyen OK, Uzgil B, Soda T, André VM, Ariano MA, Levine MS. Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF. J Neurosci Res. 2004 Dec 15;78(6):855-67. PubMed PMID: 15505789.
8. Abou-Sleymane G, Chalmel F, Helmlinger D, Lardenois A, Thibault C, Weber C, Mérienne K, Mandel JL, Poch O, Devys D, Trottier Y. Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program. Hum Mol Genet. 2006 Mar 1;15(5):691-703. Epub 2006 Jan 24. PubMed PMID: 16434483.
9. Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES. Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease. J Neurosci. 2005 Jan 5;25(1):157-63. Erratum in: J Neurosci. 2005 Apr 13;25(15):3994. PubMed PMID: 15634777.