A preliminary study targeting neuronal pathways activated following environmental enrichment by resting state functional magnetic resonance imaging

Journal of Alzheimer's Disease

Volumn 32, Issue 1, 2012, Pages 101-107

  Little, Deborah M ^a,b,c   Foxely, Sean ^d   Lazarove, Orly ^e  

^a VISN 17 Center of Excellence for Research on Returning War Veterans   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Alzheimer's disease; brain plasticity; environmental enrichment; resting state functional MRI

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ARTICLE; ATTENUATION; BRAIN CORTEX; CONTROLLED STUDY; ENVIRONMENTAL ENRICHMENT; FAMILIAL ALZHEIMER DISEASE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; MOLECULAR MECHANICS; MOUSE; NERVE CELL NETWORK; NERVE TRACT; NERVOUS SYSTEM DEVELOPMENT; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 84867494040     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-111508     Document Type: Article

References (18)

1. Markham JA, GreenoughWT(2004) Experience-driven brain plasticity: Beyond the synapse. Neuron Glia Biol 1, 351-363.
2. Lazarov O, Larson J (2007) Environmental enrichment: From mouse AD model to AD therapy, Nova Science Publishers, Inc., Chapter XI, pp. 303-328.
3. LazarovO, Robinson J,TangYP, Hairston IS,Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120, 701-713.
4. Hu YS, Xu P, Pigino G, Brady ST, Larson J, Lazarov O (2010) Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1{Delta}E9 mice. FASEB J 24, 1667-1681.
5. Ambree O, Leimer U, Herring A, Gortz N, Sachser N, Heneka MT, Paulus W, Keyvani K (2006) Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: Involvement of multiple pathways. Am J Pathol 169, 544-552.
6. Costa DA, Cracchiolo JR, Bachstetter AD, Hughes TF, Bales KR, Paul SM, Mervis RF, Arendash GW, Potter H (2007) Enrichment improves cognition in AD mice by amyloidrelated and unrelated mechanisms. Neurobiol Aging 28, 831-844.
7. Wolf SA, Kronenberg G, Lehmann K, Blankenship A, Overall R, Staufenbiel M, Kempermann G (2006) Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease. Biol Psychiatry 60, 1314-1323.
8. Kempermann G, Kuhn HG, Gage FH (1998) Experienceinduced neurogenesis in the senescent dentate gyrus. J Neurosci 18, 3206-3212.
9. Kempermann G, Gast D, Gage FH (2002) Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 52, 135-143.
10. Jonckers E, Van Audekerke J, De Visscher G, Van der Linden A, Verhoye M (2011) Functional connectivity fMRI of the rodent brain: Comparison of functional connectivity networks in rat and mouse. Plos One 6, e18876.
11. Engineer ND, Percaccio CR, Pandya PK, Moucha R, Rathbun DL, Kilgard MP (2004) Environmental enrichment improves response strength, threshold, selectivity, and latency of auditory cortex neurons. J Neurophysiol 92, 73-82.
12. Coq JO, Xerri C (2001) Sensorimotor experience modulates age-dependent alterations of the forepawrepresentation in the rat primary somatosensory cortex. Neuroscience 104, 705-715.
13. Coq JO, Xerri C (1998) Environmental enrichment alters organizational features of the forepaw representation in the primary somatosensory cortex of adult rats. Exp Brain Res 121, 191-204.
14. Godde B, Berkefeld T, David-Jurgens M, Dinse HR (2002) Age-related changes in primary somatosensory cortex of rats: Evidence for parallel degenerative and plastic-adaptive processes. Neurosci Biobehav Rev 26, 743-752.
15. Beaulieu C, Cynader M (1990) Effect of the richness of the environment on neurons in cat visual cortex. II. Spatial and temporal frequency characteristics. Brain Res Dev Brain Res 53, 82-88.
16. Frick KM, Stearns NA, Pan JY, Berger-Sweeney J (2003) Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice. Learn Mem 10, 187-198.
17. Swain RA, Harris AB, Wiener EC, Dutka MV, Morris HD, Theien BE, Konda S, Engberg K, Lauterbur PC, Greenough WT (2003) Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat. Neuroscience 117, 1037-1046.
18. Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009) Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry. Neurobiol Dis 33, 20-27.