The Essential Role of Mbd5 in the Regulation of Somatic Growth and Glucose Homeostasis in Mice

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Du, Yarui ^a   Liu, Bo ^a   Guo, Fan ^a   Xu, Guifang ^a   Ding, Yuqiang ^b   Liu, Yong ^c   Sun, Xin ^d   Xu, Guoliang ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; INSULIN; METHYL CPG BINDING DOMAIN PROTEIN 5; METHYL CPG BINDING PROTEIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BRAIN; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GROWTH RETARDATION; HYPOGLYCEMIA; INSULIN SENSITIVITY; LETHALITY; MOUSE; NONHUMAN; POSTNATAL GROWTH; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WASTING SYNDROME;

ANIMALS; BRAIN; DEVELOPMENTAL DISABILITIES; EMBRYONIC DEVELOPMENT; GLUCOSE; HOMEOSTASIS; INSULIN; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE;

EID: 84867492707     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047358     Document Type: Article

References (38)

1. Jaenisch R, Bird A, (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33Suppl: 245-254.
2. Klose RJ, Bird AP, (2006) Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31: 89-97.
3. Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, et al. (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet 23: 62-66.
4. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, et al. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13: 1924-1935.
5. Kass SU, Pruss D, Wolffe AP, (1997) How does DNA methylation repress transcription? Trends Genet 13: 444-449.
6. Ng HH, Bird A, (1999) DNA methylation and chromatin modification. Curr Opin Genet Dev 9: 158-163.
7. Razin A, (1998) CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17: 4905-4908.
8. Fan G, Hutnick L, (2005) Methyl-CpG binding proteins in the nervous system. Cell Res 15: 255-261.
9. Hendrich B, Tweedie S, (2003) The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet 19: 269-277.
10. Roloff TC, Ropers HH, Nuber UA, (2003) Comparative study of methyl-CpG-binding domain proteins. BMC Genomics 4: 1.
11. Xu GL, Bestor TH, Bourc'his D, Hsieh CL, Tommerup N, et al. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402: 187-191.
12. Laget S, Joulie M, Le Masson F, Sasai N, Christians E, et al. (2010) The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA. PLoS One 5: e11982.
13. Jaillard S, Dubourg C, Gerard-Blanluet M, Delahaye A, Pasquier L, et al. (2009) 2q23.1 microdeletion identified by array comparative genomic hybridisation: an emerging phenotype with Angelman-like features? J Med Genet 46: 847-855.
14. Wagenstaller J, Spranger S, Lorenz-Depiereux B, Kazmierczak B, Nathrath M, et al. (2007) Copy-number variations measured by single-nucleotide-polymorphism oligonucleotide arrays in patients with mental retardation. Am J Hum Genet 81: 768-779.
15. Williams SR, Mullegama SV, Rosenfeld JA, Dagli AI, Hatchwell E, et al. (2009) Haploinsufficiency of MBD5 associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Eur J Hum Genet 18: 436-441.
16. Chung BH, Stavropoulos J, Marshall CR, Weksberg R, Scherer SW, et al. (2011) 2q23 de novo microdeletion involving the MBD5 gene in a patient with developmental delay, postnatal microcephaly and distinct facial features. Am J Med Genet A 155: 424-429.
17. van Bon BW, Koolen DA, Brueton L, McMullan D, Lichtenbelt KD, et al. (2010) The 2q23.1 microdeletion syndrome: clinical and behavioural phenotype. Eur J Hum Genet 18: 163-170.
18. Talkowski ME, Mullegama SV, Rosenfeld JA, van Bon BW, Shen Y, et al. (2011) Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder. Am J Hum Genet 89: 551-563.
19. Grosso S, Pucci L, Curatolo P, Coppola G, Bartalini G, et al. (2008) Epilepsy and electroencephalographic anomalies in chromosome 2 aberrations. A review. Epilepsy Res 79: 63-70.
20. Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A, (2001) Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol 229: 141-162.
21. Walenkamp MJ, Wit JM, (2007) Genetic disorders in the GH IGF-I axis in mouse and man. Eur J Endocrinol 157Suppl 1: S15-26.
22. Jansson JO, Eden S, Isaksson O, (1985) Sexual dimorphism in the control of growth hormone secretion. Endocr Rev 6: 128-150.
23. Giustina A, Mazziotti G, Canalis E, (2008) Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29: 535-559.
24. Ooi GT, Cohen FJ, Tseng LY, Rechler MM, Boisclair YR, (1997) Growth hormone stimulates transcription of the gene encoding the acid-labile subunit (ALS) of the circulating insulin-like growth factor-binding protein complex and ALS promoter activity in rat liver. Mol Endocrinol 11: 997-1007.
25. Liu JL, LeRoith D, (1999) Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology 140: 5178-5184.
26. Zhu X, Gleiberman AS, Rosenfeld MG, (2007) Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev 87: 933-963.
27. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103.
28. Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, et al. (2003) Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144: 3799-3810.
29. Dominici FP, Hauck S, Argentino DP, Bartke A, Turyn D, (2002) Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice. J Endocrinol 173: 81-94.
30. Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, et al. (2010) Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A 107: 6028-6033.
31. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, et al. (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23: 185-188.
32. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, et al. (2003) Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A 100: 6777-6782.
33. Hendrich B, Guy J, Ramsahoye B, Wilson VA, Bird A, (2001) Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev 15: 710-723.
34. Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, et al. (2010) A human MAP kinase interactome. Nat Methods 7: 801-805.
35. Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, et al. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A 105: 9397-9402.
36. Nowakowska BA, Obersztyn E, Szymanska K, Bekiesinska-Figatowska M, Xia Z, et al. (2010) Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C. Am J Med Genet B Neuropsychiatr Genet 153B: 1042-1051.
37. Liu P, Jenkins NA, Copeland NG, (2003) A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13: 476-484.
38. Kaufman HE, Adams EC, (1954) Water-Soluble Chelates in Histochemical Staining. Science 120: 723-724.