Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT): establishment of workflow and initial clinical data

Radiation Oncology

Volumn 7, Issue 1, 2012, Pages

  Combs, Stephanie E ^a   Kessel, Kerstin A ^a   Herfarth, Klaus ^a   Jensen, Alexandra ^a   Oertel, Susanne ^a   Blattmann, Claudia ^a   Ecker, Swantje ^a   Hoess, Angelika ^a   Martin, Eike ^a   Witt, Olaf ^a,b   Jäkel, Oliver ^a   Kulozik, Andreas E ^a   Debus, Jürgen ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Carbon ion radiotherapy; Children; Proton radiation

Indexed keywords

ADENOID CYSTIC CARCINOMA; ADOLESCENT; ADULT; ARTICLE; CHILD; CHILDHOOD CANCER; CHORDOMA; CLINICAL ARTICLE; FEMALE; FOLLOW UP; HUMAN; ION THERAPY; MALE; NASOPHARYNX FIBROMA; OSTEOSARCOMA; PARAMENINGEAL DISORDER; PARTICLE THERAPY; PATIENT POSITIONING; PILOCYTIC ASTROCYTOMA; PRESCHOOL CHILD; RHABDOMYOSARCOMA; SCHOOL CHILD; TREATMENT PLANNING; TREATMENT RESPONSE; TUMOR RECURRENCE; WORKFLOW;

ADOLESCENT; ADULT; ANESTHESIA; ASTROCYTOMA; BRAIN NEOPLASMS; CARBON; CHILD; CHILD, PRESCHOOL; CHONDROSARCOMA; FEMALE; GERMANY; HUMANS; IONS; MALE; PATIENT POSITIONING; PEDIATRICS; PILOT PROJECTS; PROTONS; SKULL BASE NEOPLASMS; WORKFLOW; YOUNG ADULT;

EID: 84867473196     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-7-170     Document Type: Article

References (29)

1. Miralbell R, Lomax A, Cella L, Schneider U. Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys 2002, 54:824-829. 10.1016/S0360-3016(02)02982-6, 12377335.
2. Krejcarek SC, Grant PE, Henson JW, Tarbell NJ, Yock TI. Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation. Int J Radiat Oncol Biol Phys 2007, 68:646-649. 10.1016/j.ijrobp.2007.02.021, 1955224, 17449195.
3. Childs SK, Kozak KR, Friedmann AM, Yeap BY, Adams J, Macdonald SM, et al. Proton radiotherapy for Parameningeal Rhabdomyosarcoma: clinical outcomes and late effects. Int J Radiat Oncol Biol Phys 2012, 82(2):635-642. Epub 2011 Mar 4, 10.1016/j.ijrobp.2010.11.048, 3290917, 21377294.
4. Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, et al. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer 2011, 117(19):4522-4530. Epub 2011 Mar 29, 10.1002/cncr.26037, 21448934.
5. Cotter SE, Herrup DA, Friedmann A, Macdonald SM, Pieretti RV, Robinson G, et al. Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and Dosimetry compared to intensity-modulated radiation therapy. Therapy Int J Radiat Oncol Biol Phys 2011, 81(5):1367-1373. Epub 2010 Oct 8.
6. Macdonald SM, Trofimov A, Safai S, Adams J, Fullerton B, Ebb D, et al. Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes. Int J Radiat Oncol Biol Phys 2011, 79:121-129. 10.1016/j.ijrobp.2009.10.069, 20452141.
7. Macdonald SM, Yock TI. Proton beam therapy following resection for childhood ependymoma. Childs Nerv Syst 2010, 26:285-291. 10.1007/s00381-009-1059-4, 20024657.
8. Macdonald SM, Safai S, Trofimov A, Wolfgang J, Fullerton B, Yeap BY, et al. Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons. Int J Radiat Oncol Biol Phys 2008, 71:979-986. 10.1016/j.ijrobp.2007.11.065, 18325681.
9. Petit JH, Biller BM, Yock TI, Swearingen B, Coen JJ, Chapman P, et al. Proton stereotactic radiotherapy for persistent adrenocorticotropin-producing adenomas. J Clin Endocrinol Metab 2008, 93:393-399. 10.1210/jc.2007-1220, 18029460.
10. Yock T, Schneider R, Friedmann A, Adams J, Fullerton B, Tarbell N. Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons. Int J Radiat Oncol Biol Phys 2005, 63:1161-1168. 10.1016/j.ijrobp.2005.03.052, 15950401.
11. Rutz HP, Weber DC, Goitein G, Ares C, Bolsi A, Lomax AJ, et al. Postoperative spot-scanning proton radiation therapy for chordoma and chondrosarcoma in children and adolescents: initial experience at paul scherrer institute. Int J Radiat Oncol Biol Phys 2008, 71:220-225. 10.1016/j.ijrobp.2007.09.014, 18068310.
12. Timmermann B, Lomax AJ, Nobile L, Grotzer MA, Weiss M, Kortmann RD, et al. Novel technique of craniospinal axis proton therapy with the spot-scanning system: avoidance of patching multiple fields and optimized ventral dose distribution. Strahlenther Onkol 2007, 183:685-688. 10.1007/s00066-007-1759-1, 18040613.
13. Keating N, Yock T, Tarbell N. Comparative analysis of second malignancy risk in patients treated with proton therapy vs. conventional photon therapy. Presented at: the American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting; Sept.21-25, 2008 2008, Boston, Ref Type: Abstract.
14. Combs SE, Ellerbrock M, Haberer T, Habermehl D, Hoess A, Jakel O, et al. Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patients. Acta Oncol 2010, 49:1132-1140. 10.3109/0284186X.2010.498432, 20831505.
15. Schlampp I, Karger CP, Jakel O, Scholz M, Didinger B, Nikoghosyan A, et al. Temporal lobe reactions after radiotherapy with carbon ions: incidence and estimation of the relative biological effectiveness by the local effect model. Int J Radiat.Oncol Biol Phys 2011, 80(3):815-823. Epub 2010 Jul 16, 10.1016/j.ijrobp.2010.03.001, 20638186.
16. Schulz-Ertner D, Nikoghosyan A, Didinger B, Munter M, Jakel O, Karger CP, et al. Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques. Cancer 2005, 104:338-344. 10.1002/cncr.21158, 15937907.
17. Jensen AD, Nikoghosyan A, Windemuth-Kieselbach C, Debus J, Munter MW. Combined treatment of malignant salivary gland tumours with intensity-modulated radiation therapy (IMRT) and carbon ions: COSMIC. BMC Cancer 2010, 10:546. 10.1186/1471-2407-10-546, 2958954, 20937120.
18. Combs SE, Jakel O, Haberer T, Debus J. Particle therapy at the Heidelberg Ion Therapy Center (HIT) - Integrated research-driven university-hospital-based radiation oncology service in Heidelberg. Germany Radiother Oncol 2010, 95:41-44.
19. Combs SE, Kieser M, Rieken S, Habermehl D, Jakel O, Haberer T, et al. Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial. BMC Cancer 2010, 10:478. 10.1186/1471-2407-10-478, 2944178, 20819220.
20. Blattmann C, Oertel S, Schulz-Ertner D, Rieken S, Haufe S, Ewerbeck V, et al. Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma. BMC. Cancer 2010, 10:96. 10.1186/1471-2407-10-96, 2846886, 20226028.
21. Schulz-Ertner D, Karger CP, Feuerhake A, Nikoghosyan A, Combs SE, Jakel O, et al. Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int J Radiat Oncol Biol Phys 2007, 68:449-457. 10.1016/j.ijrobp.2006.12.059, 17363188.
22. Schulz-Ertner D, Nikoghosyan A, Hof H, Didinger B, Combs SE, Jakel O, et al. Carbon ion radiotherapy of skull base chondrosarcomas. Int J Radiat Oncol Biol Phys 2007, 67:171-177. 10.1016/j.ijrobp.2006.08.027, 17056193.
23. Brodin NP, Rosenschold PM, Aznar MC, Kiil-Berthelsen A, Vogelius IR, Nilsson P, et al. Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma. Acta Oncol 2011, 50:806-816. 10.3109/0284186X.2011.582514, 21767178.
24. Kozak KR, Adams J, Krejcarek SJ, Tarbell NJ, Yock TI. A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys 2009, 74:179-186. 10.1016/j.ijrobp.2008.06.1942, 19019562.
25. Rombi B, Delaney TF, Macdonald SM, Huang MS, Ebb DH, Liebsch NJ, et al. Proton radiotherapy for pediatric Ewing's sarcoma: initial clinical outcomes. Int J Radiat Oncol Biol Phys 2012, 82(3):1142-1148. Epub 2011 Aug 18, 10.1016/j.ijrobp.2011.03.038, 21856094.
26. Winkfield KM, Linsenmeier C, Yock TI, Grant PE, Yeap BY, Butler WE, et al. Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. Int J Radiat Oncol Biol Phys 2009, 73:716-721. 10.1016/j.ijrobp.2008.05.010, 18676089.
27. Moeller BJ, Chintagumpala M, Philip JJ, Grosshans DR, McAleer MF, Woo SY, et al. Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy. Radiat Oncol 2011, 6:58. 10.1186/1748-717X-6-58, 3123575, 21635776.
28. Chung CS, Keating N, Yock T, Tabell N. Comparative analysis of second malignancy risk in patients treated with proton therapy versus conventional photon therapy. Int J Radiat Oncol Biol Phys 2011, 72:Page S8.
29. Bettega D, Calzolari P, Hessel P, Stucchi CG, Weyrather WK. Neoplastic transformation induced by carbon ions. Int J Radiat Oncol Biol Phys 2009, 73:861-868. 10.1016/j.ijrobp.2008.07.067, 19135314.