Phage display generation of a novel human anti-CD1A monoclonal antibody with potent cytolytic activity

British Journal of Haematology

Volumn 159, Issue 3, 2012, Pages 299-310

  Bechan, Gitanjali I ^a   Lee, David W ^a   Zajonc, Dirk M ^b   Heckel, Diana ^a   Xian, Rena ^a   Throsby, Mark ^c   van Meijer, Marja ^d   Germeraad, Wilfred T V ^e   Kruisbeek, Anna M ^d   Egeler, R Maarten ^f   Arceci, Robert J ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c Merus BV   (Netherlands)

^d CRUCELL HOLLAND BV   (Netherlands)

^e MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

CD1A; Immunotherapy; Langerhans cell histiocytosis; Monoclonal antibody; T lineage acute lymphoblastic leukaemia

Indexed keywords

CD1 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD1A; MONOCLONAL ANTIBODY CR2113; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY ISOLATION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING COMPETITION; CANCER CELL CULTURE; CELL ASSAY; CELL MEDIATED CYTOTOXICITY; CONFOCAL MICROSCOPY; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNALIZATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD1; CELL LINE, TUMOR; CELL SURFACE DISPLAY TECHNIQUES; HUMANS; IMMUNOGLOBULIN G; KINETICS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED NOD; MICE, SCID; PEPTIDE LIBRARY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SINGLE-CHAIN ANTIBODIES;

EID: 84867449429     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12033     Document Type: Article

References (41)

1. Adams, G.P. & Weiner, L.M. (2005) Monoclonal antibody therapy of cancer. n, 23, 1147-1157.
2. Allam, J.P. & Novak, N. (2006) The pathophysiology of atopic eczema. Clinical and Experimental Dermatology, 31, 89-93.
3. Allen, C.E., Li, L., Peters, T.L., Leung, H.C., Yu, A., Man, T.K., Gurusiddappa, S., Phillips, M.T., Hicks, M.J., Gaikwad, A., Merad, M. & McClain, K.L. (2010) Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. Journal of Immunology, 184, 4557-4567.
4. Amiot, M., Bernard, A., Raynal, B., Knapp, W., Deschildre, C. & Boumsell, L. (1986) Heterogeneity of the first cluster of differentiation: characterization and epitopic mapping of three CD1 molecules on normal human thymus cells. Journal of Immunology, 136, 1752-1758.
5. Amiot, M., Dastot, H., Degos, L., Schmid, M. & Boumsell, L. (1987) 'Leukocyte Typing III'. Oxford Univ Press, Oxford.
6. Arico, M., Girschikofsky, M., Genereau, T., Klersy, C., McClain, K., Grois, N., Emile, J.F., Lukina, E., De Juli, E. & Danesino, C. (2003) Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society. European Journal of Cancer, 39, 2341-2348.
7. Badalian-Very, G., Vergilio, J.A., Degar, B.A., MacConaill, L.E., Brandner, B., Calicchio, M.L., Kuo, F.C., Ligon, A.H., Stevenson, K.E., Kehoe, S.M., Garraway, L.A., Hahn, W.C., Meyerson, M., Fleming, M.D. & Rollins, B.J. (2010) Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood, 116, 1919-1923.
8. Boel, E., Verlaan, S., Poppelier, M.J., Westerdaal, N.A., Van Strijp, J.A. & Logtenberg, T. (2000) Functional human monoclonal antibodies of all isotypes constructed from phage display library-derived single-chain Fv antibody fragments. Journal of Immunological Methods, 239, 153-166.
9. Bonifaz, L.C., Bonnyay, D.P., Charalambous, A., Darguste, D.I., Fujii, S., Soares, H., Brimnes, M.K., Moltedo, B., Moran, T.M. & Steinman, R.M. (2004) In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. The Journal of Experimental Medicine, 199, 815-824.
10. Cheong, C., Idoyaga, J., Do, Y., Pack, M., Park, S.H., Lee, H., Kang, Y.S., Choi, J.H., Kim, J.Y., Bonito, A., Inaba, K., Yamazaki, S., Steinman, R.M. & Park, C.G. (2007) Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207. Journal of Immunological Methods, 324, 48-62.
11. Davies, J., Jiang, L., Pan, L.Z., LaBarre, M.J., Anderson, D. & Reff, M. (2001) Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII. Biotechnology and Bioengineering, 74, 288-294.
12. Fithian, E., Kung, P., Goldstein, G., Rubenfeld, M., Fenoglio, C. & Edelson, R. (1981) Reactivity of Langerhans cells with hybridoma antibody. Proceedings of the National Academy of Sciences of the United States of America, 78, 2541-2544.
13. Fujita, S., Sato, Y., Sato, K., Eizumi, K., Fukaya, T., Kubo, M. & Yamashita, N. (2007) Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+ CD25+ Foxp3+ regulatory T cells. Blood, 110, 3793-3803.
14. Geis, N., Zell, S., Rutz, R., Li, W., Giese, T., Mamidi, S., Schultz, S. & Kirschfink, M. (2010) Inhibition of membrane complement inhibitor expression (CD46, CD55, CD59) by siRNA sensitizes tumor cells to complement attack in vitro. Current Cancer Drug Targets, 10, 922-931.
15. Hemmerling, J., Wegner-Kops, J., von Stebut, E., Wolff, D., Wagner, E.M., Hartwig, U.F., Andre, M.C., Theobald, M., Schopf, R.E., Herr, W. & Meyer, R.G. (2011) Human epidermal Langerhans cells replenish skin xenografts and are depleted by alloreactive T cells in vivo. Journal of Immunology, 187, 1142-1149.
16. Hussein, M.R. (2008) Evaluation of Langerhans' cells in normal and eczematous dermatitis skin by CD1a protein immunohistochemistry: preliminary findings. Journal of Cutaneous Pathology, 35, 554-558.
17. Idoyaga, J., Cheong, C., Suda, K., Suda, N., Kim, J.Y., Lee, H., Park, C.G. & Steinman, R.M. (2008) Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo. Journal of Immunology, 180, 3647-3650.
18. Jordan, M.B., McClain, K.L., Yan, X., Hicks, J. & Jaffe, R. (2005) Anti-CD52 antibody, alemtuzumab, binds to Langerhans cells in Langerhans cell histiocytosis. Pediatric Blood & Cancer, 44, 251-254.
19. Kahn-Perles, B., Wietzerbin, J., Caillol, D.H. & Lemonnier, F. (1985) Delineation of three subsets of class I human T antigens (HTA) on Molt-4 cells: serologic and regulatory relationship to HLA class I antigens. Journal of Immunology, 134, 1759-1765.
20. Kelly, K.M., Beverley, P.C., Chu, A.C., Davenport, V., Gordon, I., Smith, M. & Pritchard, J. (1994) Successful in vivo immunolocalization of Langerhans cell histiocytosis with use of a monoclonal antibody, NA1/34. Journal of Pediatrics, 125, 717-722.
21. Klangsinsirikul, P., Carter, G.I., Byrne, J.L., Hale, G. & Russell, N.H. (2002) Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution. Blood, 99, 2586-2591.
22. de Kruif, J., Terstappen, L., Boel, E. & Logtenberg, T. (1995) Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library. Proceedings of the National Academy of Sciences of the United States of America, 92, 3938-3942.
23. Li, H., Kaplan, D.H., Matte-Martone, C., Tan, H.S., Venkatesan, S., Johnson, K., Demetris, A.J., McNiff, J., Shlomchik, M.J. & Shlomchik, W.D. (2011) Langerhans cells are not required for graft-versus-host disease. Blood, 117, 697-707.
24. Merad, M. (2005) Ontogeny of Lagerhans cells and graft versus host disease. Advances in Experimental Medicine and Biology, 560, 115-123.
25. Merad, M., Hoffmann, P., Ranheim, E., Slaymaker, S., Manz, M.G., Lira, S.A., Charo, I., Cook, D.N., Weissman, I.L., Strober, S. & Engleman, E.G. (2004) Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nature Medicine, 10, 510-517.
26. Merle-Beral, H., Boumsell, L., Michel, A. & Debre, P. (1989) CD1 expression on B-CLL lymphocytes. British Journal of Haematology, 71, 209-212.
27. Minkov, M., Grois, N., Braier, J., Rosso, D., Arico, M., Broadbent, V., Gadner, H. & Ladisch, S. (2003) Immunosuppressive treatment for chemotherapy-resistant multisystem Langerhans cell histiocytosis. Medical and Pediatric Oncology, 40, 253-256.
28. Misery, L., Campos, L., Dezutter-Dambuyant, C., Guyotat, D., Treille, D., Schmitt, D. & Thivolet, J. (1992) CD1-reactive leukemic cells in bone marrow: presence of Langerhans cell marker on leukemic monocytic cells. European Journal of Haematology, 48, 27-32.
29. Nquyen, K. & Tazi, A. (2006) [Langerhans cell histiocytosis in adults]. La Revue du praticien, 56, 1863-1871.
30. Olive, D., Dubreuil, P. & Mawas, C. (1984) Two distinct TL-like molecular subsets defined by monoclonal antibodies on the surface of human thymocytes with different expression on leukemia lines. Immunogenetics, 20, 253-264.
31. Pless, D.D., Torres, E.R., Reinke, E.K. & Bavari, S. (2001) High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A. Infection and Immunity, 69, 570-574.
32. Porcelli, S.A. (1995) The CD1 Family: A Third Lineage of Antigen-Presenting Molecules. Academic Press Inc., USA.
33. Porcelli, S.A. & Modlin, R.L. (1999) The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annual Review of Immunology, 17, 297-329.
34. Ray, A., Schmitt, D., Dezutter-Dambuyant, C., Fargier, M.C. & Thivolet, J. (1989) Reappearance of CD1a antigenic sites after endocytosis on human Langerhans cells evidenced by immunogoldrelabeling. The Journal of Investigative Dermatology, 92, 217-224.
35. Salamone, M.C., Roisman, F.R., Santiago, J., Satz, M.L. & Fainboim, L. (1990) Analysis of CD1 molecules on haematological malignancies of myeloid and lymphoid origin. I. Cell surface antigen expression. Disease Markers, 8, 265-274.
36. Shlomchik, W.D., Couzens, M.S., Tang, C.B., McNiff, J., Robert, M.E., Liu, J., Shlomchik, M.J. & Emerson, S.G. (1999) Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science, 285, 412-415.
37. Sotzik, F., Boyd, A. & Shortman, K. (1993) Surface antigens of human thymocyte populations defined by CD3, CD4 and CD8 expression: CD1a is expressed by mature thymocytes but not peripheral T cells. Immunology Letters, 36, 101-106.
38. Van Ewijk, W., de Kruif, J., Germeraad, W.T., Berendes, P., Ropke, C., Platenburg, P.P. & Logtenberg, T. (1997) Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments. Proceedings of the National Academy of Sciences of the United States of America, 94, 3903-3908.
39. Wilson, J., Cullup, H., Lourie, R., Sheng, Y., Palkova, A., Radford, K.J., Dickinson, A.M., Rice, A.M., Hart, D.N. & Munster, D.J. (2009) Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease. The Journal of Experimental Medicine, 206, 387-398.
40. Wuchter, C., Ruppert, V., Schrappe, M., Dorken, B., Ludwig, W.D. & Karawajew, L. (2002) In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia. Blood, 99, 4109-4115.
41. Zajonc, D.M., Elsliger, M.A., Teyton, L. & Wilson, I.A. (2003) Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å. Nature Immunology, 4, 808-815.