Effects of age on outcome in the SENTIS trial: Better outcomes in elderly patients

Cerebrovascular Diseases

Volumn 34, Issue 4, 2012, Pages 263-271

  Leker, Ronen R ^a   Molina, Carlos ^b   Cockroft, Kevin ^c   Liebeskind, David S ^d   Concha, Mauricio ^f   Shuaib, Ashfaq ⁱ   De Deyn, Peter Paul ^j,k   Burgin, W Scott ^g   Gupta, Rishi ^h   Dillon, William ^e   Diener, Hans Christoph ^l  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f SARASOTA MEMORIAL HOSPITAL   (United States)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

^h EMORY UNIVERSITY   (United States)

ⁱ UNIVERSITY OF ALBERTA   (Canada)

^j ZNA Middelheim   (Belgium)

^k UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^l UNIVERSITY HOSPITAL ESSEN   (Germany)

more..

Author keywords

Brain perfusion augmentation; Clinical trials; Elderly; Ischemic stroke; SENTIS

Indexed keywords

ADULT; AGE; AGED; ARTICLE; BALLOON CATHETER; BALLOON OCCLUSION; BRAIN FUNCTION; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; DISEASE SEVERITY; FEMALE; GROUPS BY AGE; HEART ATRIUM FIBRILLATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT SAFETY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RANKIN SCALE; SEX RATIO; SURVIVAL RATE; TRANSIENT ISCHEMIC ATTACK;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGEISM; CEREBRAL HEMORRHAGE; FEMALE; HUMANS; MALE; MIDDLE AGED; PERFUSION; RISK FACTORS; STROKE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84867448124     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000342668     Document Type: Article

References (16)

1. Hammer M, Jovin T, Wahr JA, Heiss WD: Partial occlusion of the descending aorta increases cerebral blood flow in a nonstroke porcine model. Cerebrovasc Dis 2009; 28: 406-410.
2. Lylyk P, Vila JF, Miranda C, Ferrario A, Romero R, Cohen JE: Partial aortic obstruction improves cerebral perfusion and clinical symptoms in patients with symptomatic vasospasm. Neurol Res 2005; 27(suppl 1):S129-135. (Pubitemid 41510943)
3. Emery DJ, Schellinger PD, Selchen D, Douen AG, Chan R, Shuaib A, Butcher KS: Safety and feasibility of collateral blood flow augmentation after intravenous thrombolysis. Stroke 2011; 42: 1135-1137.
4. Hammer MD, Schwamm L, Starkman S, Schellinger PD, Jovin T, Nogueira R, Burgin WS, Sen S, Diener HC, Watson T, Michel P, Shuaib A, Dillon W, Liebeskind DS: Safety and feasibility of NeuroFlo use in eight- To 24 h ischemic stroke patients. Int J Stroke, Epub ahead of print
5. Shuaib A, Bornstein NM, Diener HC, Dillon W, Fisher M, Hammer MD, Molina CA, Rutledge JN, Saver JL, Schellinger PD, Shownkeen H, SENTIS Trial Investigators: Partial aortic occlusion for cerebral perfusion augmentation: Safety and Efficacy of NeuroFlo in Acute Ischemic Stroke Trial. Stroke 2011; 42: 1680-1690.
6. Liebeskind DS: Aortic occlusion for cerebral ischemia: From theory to practice. Curr Cardiol Rep 2008; 10: 31-36.
7. Bhatnagar P, Sinha D, Parker RA, Guyler P, O'Brien A: Intravenous thrombolysis in acute ischaemic stroke: A systematic review and meta-analysis to aid decision making in patients over 80 years of age. J Neurol Neurosurg Psychiatry 2011; 82: 712-717.
8. Engelter ST, Reichhart M, Sekoranja L, Georgiadis D, Baumann A, Weder B, Müller F, Lüthy R, Arnold M, Michel P, Mattle HP, Tettenborn B, Hungerbühler HJ, Baumgartner RW, Sztajzel R, Bogousslavsky J, Lyrer PA: Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis. Neurology 2005; 65: 1795-1798.
9. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995; 333: 1581-1587.
10. Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Dávalos A, Erilä T, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Köhrmann M, Larrue V, Lees KR, Machnig T, Roine RO, Toni D, Vanhooren G, Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy Investigators: Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST). Stroke 2008; 39: 3316-3322.
11. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, Sorlie PD, Sotoodehnia N, Turan TN, Virani SS, Wong ND, Woo D, Turner MB, American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Executive summary: Heart disease and stroke statistics- 2012 update: A report from the American Heart Association. Circulation 2012; 125: 188-197.
12. Arkadir D, Eichel R, Gomori JM, Ben Hur T, Cohen JE, Leker RR: Multimodal reperfusion therapy for large hemispheric infarcts in octogenarians: Is good outcome a realistic goal? AJNR Am J Neuroradiol 2012; 33: 1167-1169.
13. Qureshi AI, Suri MF, Georgiadis AL, Vazquez G, Janjua NA: Intra-arterial recanalization techniques for patients 80 years or older with acute ischemic stroke: Pooled analysis from 4 prospective studies. AJNR Am J Neuroradiol 2009; 30: 1184-1189.
14. Berrouschot J, Rother J, Glahn J, Kucinski T, Fiehler J, Thomalla G: Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (1 or = 80 years) stroke patients. Stroke 2005; 36: 2421-2425. (Pubitemid 41566970)
15. Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR: Influence of age on outcome from thrombolysis in acute stroke: A controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA). Stroke 2011; 41: 2840-2848.
16. Nathoe HM, Koerselman J, Buskens E, van Dijk D, Stella PR, Plokker TH, Doevendans PA, Grobbee DE, de Jaegere PP, Octopus Study Group: Determinants and prognostic significance of collaterals in patients undergoing coronary revascularization. Am J Cardiol 2006; 98: 31-35. (Pubitemid 43902678)