Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35139-35152

  Shi, Mingjian ^a   Pedchenko, Vadim ^a   Greer, Briana H ^a,b   Van Horn, Wade D ^a   Santoro, Samuel A ^a   Sanders, Charles R ^a,b   Hudson, Billy G ^a   Eichman, Brandt F ^a,b   Zent, Roy ^a,c   Pozzi, Ambra ^a,c  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN SYNTHESIS; CONFORMATIONAL CHANGE; DOWN-REGULATION; ERK ACTIVATION; EXTRACELLULAR; INTEGRINS; LIGAND BINDING; NEGATIVE CHARGE; SALT BRIDGES;

ACTIVATION ANALYSIS; CHELATION; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

COLLAGEN;

ALPHA1 INTEGRIN; ARGININE; ARGININE 287; COLLAGEN; COLLAGEN TYPE 4; GLUTAMINE; GLUTAMINE 317; MITOGEN ACTIVATED PROTEIN KINASE; THERMOLYSIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 1;

ARTICLE; BINDING AFFINITY; COLLAGEN SYNTHESIS; DOWN REGULATION; HUMAN; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN HOMEOSTASIS; PROTEIN SUBUNIT;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE, TRANSFORMED; COLLAGEN TYPE IV; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTEGRIN ALPHA1BETA1; LAMININ; LIGANDS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, MUTANT STRAINS; MODELS, MOLECULAR; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY;

EID: 84867417441     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.358648     Document Type: Article

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