Review: Delivery of pharmaceutical agents to treat acne vulgaris: Current status and perspectives

Journal of Medical and Biological Engineering

Volumn 32, Issue 4, 2012, Pages 215-224

  Hsieh, Ming Fa ^a   Chen, Chao Hsuan ^a  

^a CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Acne vulgaris; Antimicrobial; Drug delivery system; Photodynamic therapy; Propionibacterium acnes

Indexed keywords

ACNE TREATMENT; ACNE VULGARIS; ANTIMICROBIAL; CURRENT STATUS; DRUG DELIVERY SYSTEM; HUMAN SKIN; IN-VITRO; PATHOGENIC BACTERIUM; PHARMACEUTICAL AGENTS; PHARMACEUTICAL DOSAGE FORMS; PROPIONIBACTERIUM ACNES; SOCIAL ACTIVITIES; THERAPEUTIC MODALITY;

PHOTODYNAMIC THERAPY;

DRUG DELIVERY;

ADAPALENE; AMINOLEVULINIC ACID; AZELAIC ACID; BENZOYL PEROXIDE; CLINDAMYCIN; DOXYCYCLINE; ERYTHROMYCIN; GREEN TEA EXTRACT; ISOTRETINOIN; MINOCYCLINE; RETINOIC ACID; RETINOID; SIALIDASE; SOLID LIPID NANOPARTICLE; SPHINGOMYELIN PHOSPHODIESTERASE; TAZAROTENE; TETRACYCLINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ACINETOBACTER; ACNE VULGARIS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BURN; CORYNEBACTERIUM; DRUG ADSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG TRANSPORT; DYSPEPSIA; ENAMEL HYPOPLASIA; ENCAPSULATION; ERYTHEMA; HUMAN; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LIGHT EMITTING DIODE; LIPID SOLUBILITY; LOW LEVEL LASER THERAPY; MICROCOCCUS; MICROEMULSION; MONOTHERAPY; NONHUMAN; PATHOGENESIS; PATIENT SATISFACTION; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PROPIONIBACTERIUM ACNES; PROTEIN EXPRESSION; PRURITUS; REVIEW; SKIN BIOPSY; SKIN FLORA; SKIN INFECTION; STAPHYLOCOCCUS; TOOTH DISCOLORATION; UNSPECIFIED SIDE EFFECT; VAGINA CANDIDIASIS;

EID: 84867409535     PISSN: 16090985     EISSN: None     Source Type: Journal    
DOI: 10.5405/jmbe.901     Document Type: Review

References (108)

1. H. Gollnick, W. Cunliffe, D. Berson, B. Dreno, A. Finlay, J. J. Leyden, A. R. Shalita, D. Thiboutot and T. Schwarz, "Management of acne: a report from a global alliance to improve outcomes in acne," J. Am. Acad. Dermatol, 49: S1-S37, 2003.
2. J. Leyden, "The evolving role of propionibacterium acnes in acne"Semin. Cutan. Med Surg., 20: 139-143, 2001.
3. C. Dessinioti and A. D. Katsambas, "The role of Propionibacterium acnes in acne pathogenesis: facts and controversies," Clin. Dermatol, 28: 2-7, 2010.
4. H. Bruggemann, "Insights in the pathogenic potential of Propionibacterium acnes from its complete genome," Semin. Cutan. Med. Surg., 24: 67-72, 2005.
5. E. Healy and N. Simpson, "Acne vulgaris," Br. Med J., 308: 831-833, 1994.
6. C. Holland, T. N. Mak, U. Zimny-Arndt, M. Schmid, T. F. Meyer, P. R. Jungblut and H. Brueggemann, "Proteomic identification of secreted proteins of Propionibacterium acnes," BMC Microbiol, 10:230,2010.
7. D. Rigopoulos, G. Larios and A. D. Katsambas, "The role of isotretinoin in acne therapy: why not as first-line therapy? Facts and controversies," Clin. Dermatol, 28: 24-30, 2010.
8. A. M. Layton, B. Dreno, H. P. M. Gollnick and C. C. Zouboulis, "A review of the European Directive for prescribing systemic isotretinoin for acne vulgaris," J. Eur. Acad Dermatol. Venereal, 20: 773-776, 2006.
9. C. J. Verfaille, M. Coel, I. H. Boersma, J. Mertens, M. Borgers and D. Roseeuw, "Oral Rl 15866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study," Br. J. Dermatol, 157: 122-126, 2007.
10. R. Fried and M. Nighland. "Acne quality of life and patient satisfaction following treatment with tretinoin pump," J. Drugs Dermatol, 8: 1080-1085, 2009.
11. T. Dai, Y. Huang and M. R. Hamblin, "Photodynamic therapy for localized infections-state of the art," Photodiagnosis Photodyn. Ther, 6: 170-188, 2009.
12. R. Bojar and K. Holland, "Acne and Propionibacterium acnes," Clin. Dermatol, 22: 375-379, 2004.
13. J. H. Cove, K. T. Holland and W. J. Cunliffe, "Effects of oxygen concentration on biomass production, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture," J. Gen. Microbiol, 129: 3327-3334, 1983.
14. E. A. Eady and E. Ingham, "Propionibacterium acnes: Friend or foe?"Rev. Med. Microbiol, 5: 163-173, 1994.
15. P. A. Grange, B. Weill, N. Dupin and F. Batteux, "Does inflammatory acne result from imbalance in the keratinocyte innate immune response?" Microbes. Infect, 12: 1085-1090, 2010.
16. S. W. Youn, "The role of facial sebum secretion in acne pathogenesis: facts and controversies," Clin. Dermatol, 28: 8-11, 2010.
17. D. Holland and A. Jeremy, "The role of inflammation in the pathogenesis of acne and acne scarring," Semin. Cutan. Med. Surg., 24: 79-83, 2005.
18. H. Bruggemann, A. Henne, F. Hoster, H. Liesegang, A. Wiezer, A. Strittmatter, S. Hujer, P. Durre and G. Gottschalk, "The complete genome sequence of Propionibacterium acnes, a commensal of human skin,"Science, 305: 671-673, 2004.
19. T. Nakatsuji, Y. Liu, C. Huang, R. L. Gallo and C. Huang, "Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris," PLoS One, 3: el551, 2008.
20. C. Huang, Y Liu, T. Nakatsuji, Y Shi, R. L. Gallo, S. Lin and C. Huang, "Proteomics integrated with Escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propioni-bacterium acnes," Proteomics Clin. Appl, 2: 1234-1245, 2008.
21. C. Huang, T. Nakatsuji, Y Liu and Y Shi, "In vivo tumor secretion probing via ultrafiltration and tissue chamber: implication for anti-cancer drugs targeting secretome," Recent Pat Anticancer Drug Discov., 3: 48-54, 2008.
22. E. M. Gribbon, W. J. Cunliffe and K. T. Holland, "Interaction of Propionibacterium acnes with skin lipids in vitro," J. Gen. Microbiol., 139: 1745-1751, 1993.
23. K. Gase, J. J. Ferretti, C. Primeaux and W. M. Mcshan, "Identification, cloning, and expression of the CAMP factor gene (cfa) of group A streptococci," Infect Immun., 67: 4725-4731, 1999.
24. C. W. Lo, Y K. Lai, Y T. Liu, R. L. Gallo and C. M. Huang, "Staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting beta-hemolysin and CAMP factor,"/. Invest Dermatol, 131: 401-409, 2011.
25. M. Soerensen, T. N. Mak, R. Hurwitz, L. A. Ogilvie, H. J. Mollenkopf, T. F. Meyer and H. Brueggemann, "Mutagenesis of Propionibacterium acnes and analysis of two CAMP factor knock-out mutants," J. Microbiol. Methods, 83: 211-216, 2010.
26. T. Tsai, T. Tsai, W. Wu, J. T. Tseng and P. Tsai, "In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes,"FoodChem., 119: 964-968, 2010.
27. R. D. Ashby J. A. Zerkowski, D. K. Y Solaiman and L. S. Liu, "Biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium Propionibacterium acnes," New Biotech., 28: 24-30, 2011.
28. J. L. Johnson and C. S. Cummins, "Cell wall composition and deoxyribonucleic acid similarities among the anaerobic coryneforms, classical propionibacteria, and strains of Arachnia propionica," J. Bacterial, 109: 1047-1066, 1972.
29. T. Nakatsuji, Y Shi, W. Zhu, C. Huang, Y Chen, D. Lee, J. W. Smith, C. C. Zouboulis, R. L. Gallo and C. Huang, "Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo," Proteomics, 8: 3406-3415, 2008.
30. E. Adisen, J. Yiiksek, O. Erdem, F. N. Aksakal and A. B. Aksakal, "Expression of human neutrophil proteins in acne vulgaris," J. Eur.Acad. Dermatol. Venereal, 24: 32-37, 2010.
31. J. Wiesner and A. Vilcinskas, "Antimicrobial peptides: the ancient arm of the human immune system," Virulence, 1: 440-464, 2010.
32. G F. Webster, M. R. Ruggieri and K. J. McGinley "Correlation of Propionibacterium acnes populations with the presence of triglycerides on nonhuman skin," Appl. Environ. Microbiol, 41: 1269-1270, 1981.
33. M. Takaoki and H. Kawaji, "Impaired antibody response against T-dependent antigens in rhino mice," Immunology, 40: 27-32, 1980.
34. J. S. Strauss, D. P. Krowchuk, J. J. Leyden, A. W. Lucky, A. R. Shalita, E. C. Siegfried, D. M. Thiboutot, A. S. Van Voorhees, K. A. Beutner, C. K. Sieck and R. Bhushan, "Guidelines of care for acne vulgaris management,"/. Am. Acad Dermatol, 56: 651-663, 2007.
35. L. F. Eichenfield, J. F. Fowler Jr., R. G Fried, S. F. Friedlander, M. L. Levy and G F. Webster, "Perspectives on therapeutic options for acne: an update," Semin. Cutan. Med Surg., 29: 13-16, 2010.
36. S. E. Garner, A. Eady, C. M. Popescu, J. Newton and A. L. W. Po, "Minocycline for acne vulgaris: efficacy and safety," Cochrane DatabaseSyst. Rev, CD002086, 2003.
37. J. J. Leyden, K. Kaidbey and E. H. Gans, "The antimicrobial effects in vivo of minocycline, doxycycline and tetracycline in humans," J. Dermatol. Treat, 7: 223-225, 1996.
38. L. Maffeis and S. Veraldi, "Minocycline in the treatment of acne: latest findings," G. Ital Dermatol. Venereal, 145: 425-429, 2010.
39. R. T. Plott and M. S. Wortzman, "Key bioavailability features of a new extended-release formulation of minocycline hydrochloride tablets," Cutis, 78: 6-10, 2006.
40. K. Cha, J. Park, W Cho, D. Gu, K. Jeong and S. Hwang, "Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia," Arch. Pharm. Res., 32: 1593-1598,2009.
41. R. V Keny S. A. Mankame and C. F. Lourenco, "Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets," Indian. J. Pharm. Sci., 71: 295-302, 2009.
42. H. Tan, "Antibacterial therapy for acne: a guide to selection and use of systemic agents," Am. J. Clin. Dermatol, 4: 307-314, 2003.
43. P. Coates, S. Vyakrnam, J. C. Ravenscroft, G I. Stables, W J. Cunliffe, J. J. Leyden, J. Johnson, E. A. Eady and J. H. Cove, "Efficacy of oral isotretinoin in the control of skin and nasal colonization by antibiotic-resistant propionibacteria in patients with acne,"fe J. Dermatol, 153: 1126-1136, 2005.
44. C. N. Ellis, J. Leyden, H. I. Katz, M. T. Goldfarb, J. Hickman, T. M. Jones and E. Tschen, "Therapeutic studies with a new combination benzoyl peroxide/clindamycin topical gel in acne vulgaris," Cutis, 67: 13-20, 2001.
45. H. Abdulla and A. Shalita, "Topical clindamycin preparations in the treatment of acne vulgaris," Expert Rev. Dermatol, 4: 155-162,2009.
46. J. L. Lesher Jr., D. K. Chalker and J. G Smith Jr., "An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris," J. Am. Acad. Dermatol, 12: 526-531, 1985.
47. A. Shalita, J. S. Weiss, D. K. Chalker, C. N. Ellis, A Greenspan, H. I. Katz, I. Kantor, L. E. Millikan, T. Swinehart, L. Swinyer, C. Whitmore, M. Baker and J. Czernielewski, "A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial," J. Am. Acad. Dermatol, 34: 482-485, 1996.
48. M. Kawashima, S. Harada, J. Czernielewski and Y Miyachi, "Adapalene gel 0.1%, topical retinoid-like molecule, for the treatment of Japanese patients with acne vulgaris: a multicenter, randomized, investigator-blinded, dose-ranging study," Skin Res., 6: 494-503, 2007.
49. A. W Lucky, S. I. Cullen, T. Funicella, M. T. Jarratt, T, Jones and M. E. Reddick, "Double-blind, vehicle-controlled, multicenter comparison of two 0.025% tretinoin creams in patients with acne vulgaris," J. Am. Acad. Dermatol, 38: S24-S30, 1998.
50. A. W Lucky, S. I. Cullen, M. T. Jarratt and J. W Quigley "Comparative efficacy and safety of two 0.025% tretinoin gels: results from a multicenter, double-blind, parallel study," J. Am. Acad Dermatol, 38: S17-S23, 1998.
51. R. A. S. Chandraratna, "Tazarotene-first of a new generation of receptor-selective retinoids," Br. J. Dermatol, 135: 18-25, 1996.
52. M. L. Elsaie, M. F. Abdelhamid, L. T. Elsaaiee and H. M. Emam, "The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris," J. Drugs Dermatol, 8: 358-364, 2009.
53. J. Y Fang, T. L. Hwang, Y L. Huang and C. L. Fang, "Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol," Int. J. Pharm., 310: 131-138,2006.
54. C. H. Chen, M. F. Hsieh, Y. N. Ho, C. M. Huang, J. S. Lee, C. Y. Yang and Y. Chang, "Enhancement of catechin skin permeation via a newly fabricated mPEG-PCL-graft-2-hydroxycellulose membrane,"/. Membr. Sci., 371: 134-140, 2011.
55. J. Buse and A. El-Aneed, "Properties, engineering and applications of lipid-based nanoparticle drug-delivery systems: current research and advances," Nanomedicine, 5: 1237-1260, 2010.
56. D. Yang, D. Pornpattananangkul, T. Nakatsuji, M. Chan, D. Carson, C. M. Huang and L. F. Zhang, "The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes," Biomateriah, 30: 6035-6040, 2009.
57. C. M. Huang, C. Chen, D. Pornpattananangkul, L. Zhang, M. Chan, M. F. Hsieh and L. F. Zhang, "Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids," Biomateriah, 32:214-221,2011.
58. L. Zhang, J. M. Chan, F. X. Gu, J. Rhee, A. Z. Wang, A. F. Radovic-Moreno, F. Alexis, R. Langer and O. C. Farokhzad, "Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform," ACSNana, 2: 1696-1702, 2008.
59. Y Lin, Z. Huang, R. Zhuo and J. Fang, "Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery,"Int. J. Nanomed., 5: 117-128, 2010.
60. S. M. Moghimi and T. Kissel, "Particulate nanomedicines," Adv. DrugDeliv. Rev., 58: 1451-1455, 2006.
61. V. M. Meidan, M. C. Bonner and B. B. Michniak, "Transfollicular drug delivery: Is it a reality?" Int. J. Pharm., 306: 1-14, 2005.
62. T. W. Prow, J. E. Grice, L. L. Lin, R. Faye, M. Butler, W. Becker, E. M.T. Wurm, C. Yoong, T. A. Robertson, H. P. Soyer and M. S. Roberts, "Nanoparticles and microparticlrs for skin drug delivery," Adv. DrugDeliv. Rev, 63: 470-491, 2011.
63. J. Lademann, H. Richter, A. Teichmann, N. Otberg, U. Blume-Peytavi, B. Weiss, U. F. Schaefer, C. M. Lehr, R. Wepf and W Sterry "Nanoparticles-an efficient carrier for drug delivery into the hair follicles," Eur. J. Pharm. Biopharm., 66: 159-164, 2007.
64. C. Beaulac, S. Sachetelli and J. Lagace, "In-vitro bactericidal efficacy of sub-MIC concentrations of liposome-encapsulated antibiotic against Gram-negative and Gram-positive bacteria," J. Antimicrob. Chemother, 41: 35-41, 1998.
65. M. Schafer-Korting, H. C. Korting and E. Ponce-Poschl, "Liposomal tretinoin for uncomplicated acne vulgaris," Clin. Investig., 72: 1086-1091, 1994.
66. M. Brisaert, M. Gabriels, V. Matthijs and J. Plaizier-Vercammen, "Liposomes with tretinoin: a physical and chemical evaluation," J. Pharm. Biomed Anal, 26: 909-917, 2001.
67. N. Skalko, M. Cajkovac and I. Jalsenjak, "Liposomes with clindamycin hydrochloride in the therapy of acne vulgaris," Int. J. Pharm., 85: 97-101, 1992.
68. J. de Leeuw, H. C. de Vijlder, P. Bjerring and H. A. M. Neumann, "Liposomes in dermatology today," J. Eur. Acad Dermatol. Venereal, 23: 505-516, 2009.
69. F. Shakeel, W Ramadan, M. S. Faisal, M. Rizwan, M. Faiyazuddin, G Mustafa and S. Shafiq, "Transdermal and topical delivery of anti-inflammatory agents using nanoemulsion /microemulsion: an updated review," Curr. Nanosci., 6: 184-198, 2010.
70. E. Peira, M. E. Carlotti, R. Cavalli and M. Trotta, "Azelaic acid sodium salt in the formulation of microemulsions for topical applications," Drug Deliv. Sci. Technol, 16: 375-379, 2006.
71. M. R. Gasco, M. Gallarate and F. Pattarino, "in vitro permeation of azelaic acid from viscosized microemulsions," Int. J. Pharm., 69: 193-196, 1991.
72. B. Soltes, "Intense pulsed light therapy," Obstet. Gynecol. Clin. N.Am., 37:489-499, 2010.
73. W Li, "Nanotechology-based strategies to enhance the efficacy of photodynamic therapy for cancers," Curr. Drug Metab., 10: 851-860, 2009.
74. L. E. Millikan, "Acne therapy: old wine in new vessels-the promise (and pitfalls) of new drug deliveries and regimens," Expert Rev. Dermatol, 4: 191-194, 2009.
75. J. Y Lin and H. H. Chan, "Pigmentary disorders in Asian skin: treatment with laser and intense pulsed light sources," Skin Therapy Lett, 11:8-11,2006.
76. P. Babilas, S. Schreml, R. M. Szeimies and M. Landthaler, "Intense pulsed light (IPL): a review," Lasers Surg. Med, 42: 93-104, 2010.
77. W Hongcharu, C. R. Taylor, Y Chang, D. Aghassi, K. Suthamjariya and R. R. Anderson, "Topical ALA-photodynamic therapy for the treatment of acne vulgaris," J. Invest. Dermatol, 115: 183-192,2000.
78. P. Babilas, S. Schreml, M. Landthaler and R. Szeimies, "Photodynamic therapy in dermatology: state-of-the-art," Photodermatol Photoimmunol Photomed, 26: 118-132, 2010.
79. M. A. Santos, V. G Belo and G Santos, "Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study," Dermatol. Surg, 31:910-915,2005.
80. A. F. Taub, "A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris," J. Drugs Dermatol, 10: 1010-1016,2007.
81. J. Rajanamatin and P. Choawawanich, "Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study," Dermatol. Surg., 32: 991-996, 2006.
82. C. Ash, G Town and P. Bjerring, "Relevance of the structure of time-resolved spectral output to light-tissue interaction using intense pulsed light (IPL)," Lasers Surg. Med, 40: 83-92, 2008.
83. S. E. Chang, S. J. Ahn, D. Y Rhee, J. H. Choi, K. C. Moon, H. S. Suh and S. Cho, "Treatment of facial acne papules and pustules in Korean patients using an intense pulsed light device equipped with a 530- to 750-nm filter," Dermatol. Surg., 33: 676-679, 2007.
84. O. O. Erol, A. Gurlek, G Agaoglu, E. Topcuoglu and H. Oz, "Treatment of hypertrophic scars and keloids using intense pulsed light (IPL)," Aesthetic. Plast. Surg., 32: 902-909, 2008.
85. Y S. Choi, H. S. Suh, M. Y Yoon, S. U. Min, D. H. Lee and D. H. Suh, "Intense pulsed light vs. pulsed-dye laser in the treatment of facial acne: a randomized split-face trial," J. Eur. Acad. Dermatol. Venereol, 24: 773-780, 2010.
86. S. Kawana, R. Tachihara, T. Kato and T. Omi, "Effect of smooth pulsed light at 400 to 700 and 870 to 1,200 nm for acne vulgaris in Asian skin," Dermatol. Surg, 36: 52-57, 2010.
87. J. I. Na and D. H. Suh, "Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial,"Dermatol. Surg., 33: 1228-1233, 2007.
88. C. Zane, R. Capezzera, A. Pedretti, E. Facchinetti and P. Calzavara-Pinton, "Non-invasive diagnostic evaluation of phototherapeutic effects of red light phototherapy of acne vulgaris," Photodermatol. Photoimmunol. Photomed, 24: 244-248, 2008.
89. C. Horfelt, B. Stenquist, C. B. Halldin, M. B. Ericson and A. M. Wennberg, "Single low-dose red light is as efficacious as methyl-aminolevulinate-photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring," Ada Derm.-Venereol, 89: 372-378, 2009.
90. A. Johnsson, B. Kjeldstad and T. B. Melo, "Fluoresence from pilosebaceous follicles," Arch. Dermatol. Res., 279: 190-193, 1987.
91. W C. Cunliffe and V. Goulden, "Phototherapy and acne vulgaris," fe J. Dermatol, 142: 855-856, 2000.
92. M. S. Choi, S. J. Yun, H. J. Beom, H. R. Park and J. B. Lee, "Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes," J. Dermatol, 38: 661-666, 2011.
93. W L. Lee, A. R. Shalita and M. B. Poh-Fitzpatrick, "Comparative studies of porphyrin production in Propioi-bacterium acnes and Propionibacterium granulosum," J. Bacterial., 133: 811-815, 1978.
94. B. Kjeldstad and A. Johnsson, "An action spectrum for blue and near ultraviolet inactivation of Propionibacterium acnes; with emphasis on a possible porphyrin photosensitization," Photochem. Photobiol, 43: 67-70, 1986.
95. S. Y Lee, C. E. You and M. Y Park, "Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV," Lasers Surg. Med, 39: 180-188, 2007.
96. P. Papageorgiou, A. Katsambas and A. Chu, "Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris," Br. J. Dermatol, 142: 973-978, 2000.
97. D. J. Goldberg and B. A. Russell, "Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris," J. Cosmet. Laser Ther., 8: 71-75, 2006.
98. J. Webber, Y. Luo, R. Crilly D. Fromm and D. Kessel, "An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo," J. Photochem. Photobiol. B-Biol, 35: 209-211, 1996.
99. H. Chen, C. Yu, T. Tsai, Y Hsu, R. Kuo and C. Chiang, "Topical 5-aminolevulinic acid-mediated photodynamic therapy for oral verrucous hyperplasia, oral leukoplakia and oral erythroleukoplakia," Photodiagnosis Photodyn. Ther., 4: 44-52, 2007.
100. P. McCann, T. Stafinski, C. Wong and D. Menon, "The safety and effectiveness of endoscopic and non-endoscopic approaches to the management of early esophageal cancer: a systematic review," Cancer Treat. Rev., 37: 11-62, 2011.
101. V. de Giorgi, M. Grazzini, B. Alfaioli, I. Savarese, S. A. Corciova, Q Guerriero and T. Lotti, "Cutaneous manifestations of breast carcinoma,"Dermatol. Ther, 23: 581-589, 2010.
102. B. Zhao and Y He, "Recent advances in the prevention and treatment of skin cancer using photodynamic therapy," Expert Rev. Anticancer Ther, 10: 1797-1809, 2010.
103. A. Casas, S. Battah, G D. Venosa, P. Dobbin, L. Rodriguez, H. Fukuda, A. Batlle and A. J. MacRobert, "Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy," J. Control. Release, 135: 136-143, 2009.
104. X. Wang, H. Wang, L. Zhang, M. Guo and Z. Huang, "Topical ALA PDT for the treatment of severe acne vulgaris," Photodiagnosis Photodyn. Ther, 7: 33-38, 2010.
105. M. H. Gold, "Acne and PDT: new techniques with lasers and light sources," Lasers Med. Sci., 22: 67-72, 2007.
106. C. K. Yeung, S. Y Shek, C. S. Yu, T. Kono and H. H. Chan, "Liposome-encapsulated 0.5% 5-aminolevulinic acid with intense pulsed light for the treatment of inflammatory facial acne a pilot study," Dermatol. Surg., 37: 450-459, 2011.
107. S. Kosaka, N. Miyoshi, O. E. Akilov, T. Hasan and S. Kawana, "Targeting of sebaceous glands by -aminolevulinic acid-based photodynamic therapy: an in-vivo study," Lasers Surg. Med., 43: 376-381,2011.
108. M. Haedersdal, K. Togsverd-Bo and H. C. Wulf, "Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris," J. Eur Acad. Dermatol. Venereol, 22: 267-278, 2008.