Single low-dose red light is as efficacious as methyl-aminolevulinate- photodynamic therapy for treatment of acne: Clinical assessment and fluorescence monitoring

Acta Dermato-Venereologica

Volumn 89, Issue 4, 2009, Pages 372-378

  Hörfelt, Camilla ^a   Stenquist, Bo ^a   Halldin, Christina B ^a   Ericson, Marica B ^a,b   Wennberg, Ann Marie ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Acne; Fluorescence imaging; Methyl aminolaevulinic acid; Photodynamic therapy; Propionibacterium acnes; Sebum

Indexed keywords

AMINOLEVULINIC ACID METHYL ESTER;

ACNE VULGARIS; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE SEVERITY; DRY SKIN; ERYTHEMA; FEMALE; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPIGMENTATION; MALE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; RED LIGHT; SEBUM SECRETION; SKIN BIOPSY; SKIN EXFOLIATION; TREATMENT OUTCOME;

ACNE VULGARIS; ADMINISTRATION, TOPICAL; ADULT; AMINOLEVULINIC ACID; FEMALE; HUMANS; MALE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROPIONIBACTERIUM ACNES; SEBUM; SKIN; TREATMENT OUTCOME; YOUNG ADULT;

EID: 69249140331     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.2340/00015555-0667     Document Type: Article

References (29)

1. Leyden JJ. Therapy for acne vulgaris. N Engl J Med 1997; 336: 1156-1162.
2. Webster GF. The pathophysiology of acne. Cutis 2005; 76 Suppl 2: 4-7.
3. Knor T. The pathogenesis of acne. Acta Dermatovenerol Croat 2005; 13:44-49.
4. Eady EA, Gloor M, Leyden JJ. Propionibacterium acnes resistance: a worldwide problem. Dermatology 2003; 206: 54-56. (Pubitemid 36164666)
5. McLane J. Analysis of common side effects of isotretinoin. J Am Acad Dermatol 2001; 45: S188-S194. (Pubitemid 33032599)
6. Hirsch RJ, Shalita AR. Lasers, light, and acne. Cutis 2003; 71:353-354.
7. Cunliffe WJ, editor. Acne. London: Dunitz, 1989.
8. Sigurdsson V, Knulst AC, van Weelden H. Phototherapy of acne vulgaris with visible light. Dermatology 1997; 194: 256-260. (Pubitemid 27216040)
9. Elman M, Lebzelter J. Light therapy in the treatment of acne vulgaris. Dermatol Surg 2004; 30: 139-146. (Pubitemid 38314000)
10. Divaris DX, Kennedy JC, Pottier RH. Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. Am J Pathology 1990; 136:891-897.
11. Borelli C, Merk K, Schaller M, Jacob K, Vogeser M, Weindl G, et al. In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment. Acta Derm Venereol 2006; 86: 316-319.
12. Hongcharu W, Taylor CR, Chang Y, Aghassi D, Suthamjariya K, Andeerson RR. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol 2000; 115: 183-192 (Pubitemid 30637186)
13. Caekelbergh K, Annemans L, Lambert J, Roelandts R. Economic evaluation of methyl aminolaevulinate-based photodynamic therapy in the management of actinic keratosis and basal cell carcinoma. Br J Dermatol 2006; 155: 784-790. (Pubitemid 44352560)
14. Haedersdal M, Togsverd-Bo K, Wulf HC. Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris. J Eur Acad Derm Venereol 2008; 22: 267-278. (Pubitemid 351247414)
15. Pollock B, Turner D, Stringer MR, Bojar RA, Goulden V, Stables GI, et al. Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol 2004; 151:616-622. (Pubitemid 39330886)
16. Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol 2006; 54: 647-651.
17. Wiegell SR, Wulf C. Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. Br J Dermatol 2006; 154: 969-976.
18. Hörfeit C, Stenquist B, Larkö O, Faergemann J, Wennberg AM. Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. Acta Derm Venereol 2007; 87: 325-329.
19. Hörfeit C, Funk J, Frohm-Nilsson M, Wiegleb Edström D, Wennberg AM. Topical methyl aminolevulinate photodynamic therapy for treatment of facial acne vulgaris: results of a randomised study. Br J Dermatol 2006; 152: 765-772.
20. Pillsbury DM, Shelly WB, Kligman A. A manual of cutaneous medicine. Philadelphia: WB Saunders, 1961.
21. Ericson MB, Sandberg C, Stenquist B, Gudmundson F, Karlsson M, Ros AM, et al. Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome. Br J Dermatol 2004; 151: 1204-1212. (Pubitemid 40030168)
22. Mills OH, Kligman AM. The follicular biopsy. Dermatologica 1983; 167: 57-63.
23. Wennberg AM, Gudmundson F, Stenquist B, Ternesten A, Mölne L, Rosén A, et al. In vivo detection of basal cell carcinoma using imaging spectroscopy. Acta Derm Venereol 1999;79:54-61.
24. Wiegell SR, Skiveren J, Philipsen PA, Wulf C. Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate. Br J Dermatol 2008; 158:727-733.
25. Leyden JJ. The evolving role of Propionibacterium acnes in acne. Semin Cutan Med Surg 2001; 20: 139-143.
26. Seaton ED, Mouser PE, Charakida A, Alam S, Seldon PM, Chu AC. Investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris. Br J Dermatol 2006; 155: 748-755. (Pubitemid 44352555)
27. Young S, Bolton P, Dyson M, Harvey W, Diamantopoulus C. Macrophage responsiveness to light therapy. Lasers Surg Med 1989;9:497-505.
28. Yu W, Nairn JO, Lanzafame RJ. Effects of photostimulation on wound healing in diabetic mice. Lasers Surg Med 1997; 20: 56-63. (Pubitemid 27121396)
29. Bryld LE, Jemec GB. The bacterial flora of the skin surface following routine MAL-PDT. J Dermatolog Treat 2006; 17:222-223.