HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35678-35688

  Moon, Sung Min ^a   Kim, Soo A ^b   Yoon, Jung Hoon ^c   Ahn, Sang Gun ^a  

^a Chosun University   (South Korea)

^b Dongguk University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BCL-2 GENE; BCL-2MRNA; CELL LINES; CELLULAR DIFFERENTIATION; EMBRYONIC DEVELOPMENT; HUMAN HEAD; INDUCED ACTIVITY; LUCIFERASE REPORTER ASSAYS; OVER-EXPRESSION; PROMOTER DELETIONS; TRANSFECTION ASSAYS;

ASSAYS; CELL CULTURE; CELL DEATH; GENES; TISSUE; TRANSCRIPTION FACTORS;

DRUG PRODUCTS;

CASPASE 3; PACLITAXEL; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXC6; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HOMEODOMAIN PROTEINS; HUMANS; PACLITAXEL; PROTO-ONCOGENE PROTEINS C-BCL-2; RESPONSE ELEMENTS; SEQUENCE DELETION;

EID: 84867406264     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.361675     Document Type: Article

References (46)

1. Jemal, A., Siegel, R., Xu, J., and Ward, E. (2010) Cancer statistics, 2010. CA Cancer J. Clin. 60, 277-300
2. Parkin, D. M. (2001) Global cancer statistics in the year 2000. Lancet Oncol. 2, 533-543
3. Warnakulasuriya, S. (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 45, 309-316
4. Warnakulasuriya, S. (2009) Significant oral cancer risk associated with low socioeconomic status. Evid Based Dent. 10, 4-5
5. Argiris, A., and Eng, C. (2003) Epidemiology, staging, and screening of head and neck cancer. Cancer Treat Res. 114, 15-60
6. Abate-Shen, C. (2002) Deregulated homeobox gene expression in cancer: cause or consequence? Nat. Rev. Cancer 2, 777-785
7. Veraksa, A., Del Campo, M., and McGinnis, W. (2000) Developmental patterning genes and their conserved functions: from model organisms to humans. Mol. Genet. Metab. 69, 85-100 (Pubitemid 30180692)
8. Friedmann, Y., Daniel, C. A., Strickland, P., and Daniel, C. W. (1994) Hox genes in normal and neoplastic mouse mammary gland. Cancer Res. 54, 5981-5985 (Pubitemid 24375237)
9. Castronovo, V., Kusaka, M., Chariot, A., Gielen, J., and Sobel, M. (1994) Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. Biochem. Pharmacol. 47, 137-143 (Pubitemid 24045826)
10. Chen, K. N., Gu, Z. D., Ke, Y., Li, J. Y., Shi, X. T., and Xu, G. W. (2005) Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma. Clin. Cancer Res. 11, 1044-1049 (Pubitemid 40175752)
11. Takahashi, Y., Hamada, J., Murakawa, K., Takada, M., Tada, M., Nogami, I., Hayashi, N., Nakamori, S., Monden, M., Miyamoto, M., Katoh, H., and Moriuchi, T. (2004) Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative realtime RT-PCR system. Exp. Cell Res. 293, 144-153 (Pubitemid 38064421)
12. van Oostveen, J., Bijl, J., Raaphorst, F., Walboomers, J., and Meijer, C. (1999) The role of homeobox genes in normal hematopoiesis and hematological malignancies. Leukemia. 13, 1675-1690 (Pubitemid 29535248)
13. Yahagi, N., Kosaki, R., Ito, T., Mitsuhashi, T., Shimada, H., Tomita, M. Takahashi, T., and Kosaki, K. (2004) Position-specific expression of HOX genes along the gastrointestinal tract. Congenit Anom. 44, 18-26
14. Bodey, B., Bodey, B. Jr., Siegel, S. E., and Kaiser, H. E. (2000) Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in breast carcinomas. Anticancer Res. 20, 3281-3286
15. Fujiki, K., Duerr, E. M., Kikuchi, H., Ng, A., Xavier, R. J., Mizukami, Y., Imamura, T., Kulke, M. H., and Chung, D. C. (2008) Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology 135, 907-916
16. Bodey, B., Bodey, B. Jr., Siegel, S. E., Luck, J. V., and Kaiser, H. E. (2000) Homeobox B3, B4, and C6 gene product expression in osteosarcomas as detected by immunocytochemistry. Anticancer Res. 20, 2717-2721 (Pubitemid 30614490)
17. Miller, G. J., Miller, H. L., van Bokhoven, A., Lambert, J. R., Werahera, P. N., Schirripa, O., Lucia, M. S., and Nordeen, S. K. (2003) Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Cancer Res. 63, 5879-5888 (Pubitemid 37187488)
18. Tucci, R., Campos, M. S., Matizonkas-Antonio, L. F., Durazzo, M., Pinto Junior Ddos, S., and Nunes, F. D. (2011) HOXB5 expression in oral squamous cell carcinoma. J. Appl. Oral Sci. 19, 125-129
19. Hassan, N. M., Hamada, J., Murai, T., Seino, A., Takahashi, Y., Tada, M., Zhang, X., Kashiwazaki, H., Yamazaki, Y., Inoue, N., and Moriuchi, T. (2006) Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues. Oncol Res. 16, 217-224 (Pubitemid 46211725)
20. Bijl, J., van Oostveen, J. W., Kreike, M., Rieger, E., van der Raaij-Helmer, L. M., Walboomers, J. M., Corte, G., Boncinelli, E., van den Brule, A. J., and Meijer, C. J. (1996) Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue. Blood 87, 1737-1745
21. McCabe, C. D., Spyropoulos, D. D., Martin, D., and Moreno, C. S. (2008) Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer. Cancer Res. 68, 1988-1996 (Pubitemid 351416586)
22. Grishina, I. B., Kim, S. Y., Ferrara, C., Makarenkova, H. P., Walden, P. D. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev. Biol. 288, 334-347 (Pubitemid 41790747)
23. Ricort, J. M., and Binoux, M. (2002) Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulinlike growth factor signaling pathway. J. Biol. Chem. 277, 19448-19454
24. van der Geer, P., Hunter, T., and Lindberg, R. A. (1994) Receptor proteintyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10, 251-337 (Pubitemid 24372822)
25. Lin, Y, Liu, G., Zhang, Y., Hu, Y. P., Yu, K., Lin, C., McKeehan, K., Xuan, J. W., Ornitz, D. M., Shen, M. M., Greenberg, N., McKeehan, W. L., and Wang, F. (2007) Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development 134, 723-734 (Pubitemid 46437914)
26. Danial, N. N., and Korsmeyer, S. J. (2004) Cell death: critical control points. Cell 116, 205-219 (Pubitemid 38167313)
27. Trask, D. K., Wolf, G. T., Bradford, C. R., Fisher, S. G., Devaney, K., Johnson, M., Singleton, T., and Wicha, M. (2002) Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. Laryngoscope 112, 638-644 (Pubitemid 34285929)
28. Sharma, H., Sen, S., Lo Muzio, L., Mariggiò, A., Singh, N. (2005) Antisense- mediated downregulation of antiapoptotic proteins induces apoptosis and sensitizes head and neck squamous cell carcinoma cells to chemotherapy. Cancer Biol. Ther. 4, 720-727 (Pubitemid 41351170)
29. Wolter, K. G., Wang, S. J., Henson, B. S., Wang, S., Griffith, K. A., Kumar, B., Chen, J., Carey, T. E., Bradford, C. R., D'Silva, N. J. (2006) (-)-Gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. Neoplasia 8, 163-172 (Pubitemid 43671231)
30. Li, R., Boehm, A. L., Miranda, M. B., Shangary, S., Grandis, J. R., Johnson, D. E. (2007) Targeting antiapoptotic Bcl-2 family members with cell-permeable BH3 peptides induces apoptosis signaling and death in head and neck squamous cell carcinoma cells. Neoplasia 9, 801-811 (Pubitemid 47623420)
31. Cory, S., Adams, J. M. (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656 (Pubitemid 37328916)
32. Jones, P. A., Baylin, S. B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428 (Pubitemid 34587077)
33. Gehring, W. J., Hiromi, Y. (1986) Homeotic genes and the homeobox. Annu. Rev. Genet. 20, 147-173
34. Krumlauf, R. (1994) HOX genes in vertebrate development. Cell 78, 191-201
35. De Souza Setubal Destro, M. F., Bitu, C. C., Zecchin, K. G., Graner, E., Lopes, M. A., Kowalski, L. P., Coletta, R. D. (2010) Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. Int. J. Oncol. 36, 141-149
36. Cazal, C., Sobral, A. P., de Almeida, F. C., das Graças Silva-Valenzuela, M., Durazzo, M. D., Nunes, F. D. (2006) The homeobox HOXB13 is expressed in human minor salivary gland. Oral Dis. 12, 424-427
37. Wissmann, C., Wild, P. J., Kaiser, S., Roepcke, S., Stoehr, R., Woenckhaus, M., Kristiansen, G., Hsieh, J. C., Hofstaedter, F., Hartmann, A., Knuechel, R., Rosenthal, A., Pilarsky, C. (2003) WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J. Pathol 201, 204-212 (Pubitemid 37258931)
38. Park, S., Kim, J. H., Jang, J. H. (2007) Aberrant hypermethylation of the FGFR2 gene in human gastric cancer cell lines. Biochem. Biophys. Res. Commun. 357, 1011-1015 (Pubitemid 46693672)
39. Zhu, X., Lee, K., Asa, S. L., Ezzat, S. (2007) Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells. Am. J. Pathol. 170, 1618-1628 (Pubitemid 47339306)
40. Nguyen, A., Rauch, T. A., Pfeifer, G. P., Hu, V. W. (2010) Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J. 24, 3036-3051
41. Babidge, W. J., Butler, L. M., Burton, M. A., Cowled, P. A. (2001) Methylation of CpG sites in exon 2 of the bcl-2 gene occurs in colorectal carcinoma. Anticancer Res. 21, 2809-2814 (Pubitemid 33054460)
42. Zhu, Q., Jin, Z., Yuan, Y., Lu, Q., Ge, D., Zong, M. (2011) Impact of MTHFR gene C677T polymorphism on Bcl-2 gene methylation and protein expression in colorectal cancer. Scand J. Gastroenterol. 46, 436-445
43. Svingen, T., Tonissen, K. F. (2006) Hox transcription factors and their elusive mammalian gene targets. Heredity 97, 88-96 (Pubitemid 44341508)
44. Jones, F. S., Holst, B. D., Minowa, O., De Robertis, E. M., Edelman, G. M. (1993) Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3). Proc. Natl. Acad. Sci. U.S.A. 90, 6557-6561 (Pubitemid 23207252)
45. Drenning, S. D., Marcovitch, A. J., Johnson, D. E., Melhem, M. F., Tweardy, D. J., Grandis, J. R. (1998) Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin. Cancer Res. 4, 2913-2921 (Pubitemid 28523523)
46. Trask, D. K., Wolf, G. T., Bradford, C. R., Fisher, S. G., Devaney, K., Johnson, M., Singleton, T., Wicha, M. (2002) Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation. Laryngoscope 112, 638-644 (Pubitemid 34285929)