Enhancement of protease-induced IL-6 release in monocytic U-937 cells by phorbol-12-myristate-13-acetate

Inflammation Research

Volumn 61, Issue 10, 2012, Pages 1125-1129

  Domsalla, A ^a   Melzig, Matthias F ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

IL 6; Papain; PMA; Proteases; Thrombin; Trypsin; U 937 cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 6; PAPAIN; PHORBOL 13 ACETATE 12 MYRISTATE; SERINE PROTEINASE; THROMBIN; TRYPSIN;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN U937; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR INTERACTION; MONOCYTE;

HUMANS; INTERLEUKIN-6; PAPAIN; TETRADECANOYLPHORBOL ACETATE; THROMBIN; TRYPSIN; U937 CELLS;

EID: 84867404820     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0505-z     Document Type: Article

References (11)

1. Sower LE, Froelich CJ, Carney DH, Fenton JW, Klimpel GR. Thrombin induces IL-6 production in fibroblasts and epithelial cells-evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin. J Immunol. 1995;155:895-901.
2. Naldini A, Sower L, Bocci V, Meyers B, Carney DH. Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation. J Cell Physiol. 1998;177:76-84.
3. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258-64.
4. Siller-Matula JM, Schwameis M, Blann A, Mannhalter C, Jilma B. Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects. Thromb Haemost. 2011;106:1020-33.
5. Yoshizaki K, Nishimoto N, Mihara M, Kishimoto T. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Springer Semin Immunopathol. 1998;20:247-59.
6. Gschwend M, Hecker E. Tumor-promoting compounds from Euphorbia cooperi di-and triesters of 16-hydroxy-12-desoxyphorbol. Tetrahedron Lett. 1970:567-70.
7. Goel G, Makkar HPS, Francis G, Becker K. Phorbol esters: structure, biological activity, and toxicity in animals. Int J Toxicol. 2007;26:279-88.
8. Naldini A, Carney DH, Pucci A, Pasquali A, Carraro F. Thrombin regulates the expression of proangiogenic cytokines via proteolytic activation of protease-activated receptor-1. Gen Pharmacol-Vasc S. 2000;35:255-9.
9. Biswas P, Delfanti F, Bernasconi S, Mengozzi M, Cota M, Polentarutti N, et al. Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U-937 cell line. Blood. 1998;91:258-65.
10. Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergenolle N, et al. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev. 2005;26:1-43.
11. Liang G, Barker T, Xie Z, Charlers N, Rivera J, Druey KM. Naïve T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel T (H) 2 immunity. J Allergy Clin Immunol. 2012;129:1377-86.