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1
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84875004644
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VICTRELIS™ (boceprevir) Full prescribing information (, revised 5/2011)
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VICTRELIS™ (boceprevir) Full prescribing information (www.victrelis.com, revised 5/2011).
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2
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84875005935
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INCIVEK™ (telaprevir) Full prescribing information (, revised 5/2011)
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INCIVEK™ (telaprevir) Full prescribing information (www.incivek.com, revised 5/2011).
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3
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84860322902
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New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives
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Boceprevir for untreated chronic HCV genotype 1 infection
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F. Poordad, J.J. McCone, B.R. Bacon, S. Bruno, M.P. Manns, M. Sulkowski, I.M. Jacobson, K.R. Reddy, Z.D. Goodman, N. Boparai, and M.J. DiNubile Boceprevir for untreated chronic HCV genotype 1 infection N Engl J Med 364 2011 1195 1206
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79953176289
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B.R. Bacon, S.C. Gordon, E. Lawitz, P. Marcellin, J.M. Vierling, S. Zeuzem, F. Poordad, Z.D. Goodman, H.L. Sings, N. Boparai, and M. Burroughs Boceprevir for previously treated chronic HCV genotype 1 infection N Engl J Med 364 2011 1207 1217
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Sings, H.L.9
Boparai, N.10
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Resistance to direct antiviral agents in patients with hepatitis C virus infection
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C. Sarrazin, and S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2010 447 462
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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
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M.H. Powdrill, E.P. Tchesnokov, R.A. Kozak, R.S. Russell, R. Martin, E.S. Svarovskaia, H. Mo, R.D. Kouyos, and M. Götte Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance Proc Natl Acad Sci U S A 108 2011 20509 20513
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Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
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C. Hezode, N. Forestier, G. Dusheiko, P. Ferenci, S. Pol, T. Goeser, J.P. Bronowicki, M. Bourliere, S. Gharakhanian, L. Bengtsson, and L. McNair Telaprevir and peginterferon with or without ribavirin for chronic HCV infection N Engl J Med 360 2009 1839 1850
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65449152185
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Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
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J.G. McHutchison, G.T. Everson, S.C. Gordon, I.M. Jacobson, M. Sulkowski, R. Kauffman, L. McNair, J. Alam, and A.J. Muir Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection N Engl J Med 360 2009 1827 1838
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Alam, J.8
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70349292099
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Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
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D. Ge, J. Fellay, A.J. Thompson, J.S. Simon, K.V. Shianna, T.J. Urban, E.L. Heinzen, P. Qiu, A.H. Bertelsen, A.J. Muir, and M. Sulkowski Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance Nature 461 2009 399 401
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Ge, D.1
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Heinzen, E.L.7
Qiu, P.8
Bertelsen, A.H.9
Muir, A.J.10
Sulkowski, M.11
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17
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84860313573
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Will interferon-free regimens prevail?
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C. Welsch, and S. Zeuzem Will interferon-free regimens prevail? Gastroenterology 142 2012 1351 1355
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Gastroenterology
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, pp. 1351-1355
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Welsch, C.1
Zeuzem, S.2
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18
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84867402127
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Boceprevir resistance-associated variants (RAVS) are observed more frequently in HCV (GT1)-infected patients with poor response to peginterferon alfa-2b/ribavirin
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Berlin (Abstract 9)
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S. Zeuzem, R.J. Barnard, J.A. Howe, R.A. Ogert, R. Ralston, N. Boparai, C.A. Brass, J.K. Albrecht, M. Burroughs, and V. Sniukiene Boceprevir resistance-associated variants (RAVS) are observed more frequently in HCV (GT1)-infected patients with poor response to peginterferon alfa-2b/ribavirin EASL Berlin 2011 (Abstract 9)
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(2011)
EASL
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Zeuzem, S.1
Barnard, R.J.2
Howe, J.A.3
Ogert, R.A.4
Ralston, R.5
Boparai, N.6
Brass, C.A.7
Albrecht, J.K.8
Burroughs, M.9
Sniukiene, V.10
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19
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84867398549
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Long-term outcomes following combinations treatment with boceprevir plus pegintron/ribavirin (P/R) in patients with chronic hepatitis C, genotype 1 (CHC-G1)
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Vienna (Abstract 2016)
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J.M. Vierling, R. Ralston, E.J. Lawitz, J. McCone, S. Gordon, D. Pound, M. Davis, J. Galati, I. Jacobson, and L. Rossaro Long-term outcomes following combinations treatment with boceprevir plus pegintron/ribavirin (P/R) in patients with chronic hepatitis C, genotype 1 (CHC-G1) EASL Vienna 2010 (Abstract 2016)
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(2010)
EASL
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Vierling, J.M.1
Ralston, R.2
Lawitz, E.J.3
McCone, J.4
Gordon, S.5
Pound, D.6
Davis, M.7
Galati, J.8
Jacobson, I.9
Rossaro, L.10
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20
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84890455968
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Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials
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Berlin (Abstract 8)
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J.C. Sullivan, S. De Meyer, D.J. Bartels, I. Dierynck, E. Zhang, J. Spanks, A. Tigges, N. Adda, E.C. Martin, and I.M. Jacobson Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials EASL Berlin 2011 (Abstract 8)
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(2011)
EASL
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Sullivan, J.C.1
De Meyer, S.2
Bartels, D.J.3
Dierynck, I.4
Zhang, E.5
Spanks, J.6
Tigges, A.7
Adda, N.8
Martin, E.C.9
Jacobson, I.M.10
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21
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84867403032
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Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: Interim analysis from the EXTEND study
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San Francisco (Abstract 248)
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K.E. Sherman, M.S. Sulkowski, F. Zoulim, A. Alberti, L.J. Wei, J.C. Sullivan, E.C. Martin, T.L. Kieffer, S. De Meyer, and G. Picchio Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: interim analysis from the EXTEND study AASLD San Francisco 2011 (Abstract 248)
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(2011)
AASLD
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Sherman, K.E.1
Sulkowski, M.S.2
Zoulim, F.3
Alberti, A.4
Wei, L.J.5
Sullivan, J.C.6
Martin, E.C.7
Kieffer, T.L.8
De Meyer, S.9
Picchio, G.10
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22
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82755182674
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Analysis of long-term persistance of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
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S. Susser, J. Vermehren, N. Forestier, M.W. Welker, N. Grigorian, C. Füller, D. Perner, S. Zeuzem, and C. Sarrazin Analysis of long-term persistance of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir J Clin Virol 52 2011 321 327
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J Clin Virol
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Susser, S.1
Vermehren, J.2
Forestier, N.3
Welker, M.W.4
Grigorian, N.5
Füller, C.6
Perner, D.7
Zeuzem, S.8
Sarrazin, C.9
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23
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84867403033
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Long-term follow-up analysis of the hepatitis C virus NS3 protease in patients treated with telaprevir or boceprevir: A comparison between clonal and deep sequencing
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San Francisco (Abstract 2104)
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S. Susser, S.E. Schelhorn, D. Perner, N. Grigorian, T. Lengauer, S. Zeuzem, and C. Sarrazin Long-term follow-up analysis of the hepatitis C virus NS3 protease in patients treated with telaprevir or boceprevir: a comparison between clonal and deep sequencing AASLD San Francisco 2011 (Abstract 2104)
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(2011)
AASLD
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Susser, S.1
Schelhorn, S.E.2
Perner, D.3
Grigorian, N.4
Lengauer, T.5
Zeuzem, S.6
Sarrazin, C.7
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24
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84961633113
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Retreatment with telaprevir/PEG-IFN/RBV after a short exposure to telaprevir in phase i studies: Interim results from a phase IIIB rollover trial (C219)
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San Francisco (Abstract 35)
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C. Sarrazin, H.W. Reesink, S. Zeuzem, C.J. Weegink, D. Luo, J. Witek, T.L. Kieffer, D. Bartels, I. Dierynck, S. De Meyer, and G. Picchio Retreatment with telaprevir/PEG-IFN/RBV after a short exposure to telaprevir in phase I studies: interim results from a phase IIIB rollover trial (C219) AASLD San Francisco 2011 (Abstract 35)
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(2011)
AASLD
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Sarrazin, C.1
Reesink, H.W.2
Zeuzem, S.3
Weegink, C.J.4
Luo, D.5
Witek, J.6
Kieffer, T.L.7
Bartels, D.8
Dierynck, I.9
De Meyer, S.10
Picchio, G.11
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25
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84859800942
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Treatment outcome and resistance analysis in HCV genotype 1 patients previously exposed to TMC435 monotherapy and re-treated with TMC435 in combination with PegIFNa-2a/ribavirin
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(Abstract 2068)
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O. Lenz, J. de Bruijne, L. Vijgen, T. Verbinnen, C. Weegink, H. van Marck, I. Vandenbroucke, M. Peeters, G. De Smedt, and K. Simmen Treatment outcome and resistance analysis in HCV genotype 1 patients previously exposed to TMC435 monotherapy and re-treated with TMC435 in combination with PegIFNa-2a/ribavirin EASL 2011 (Abstract 2068)
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(2011)
EASL
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Lenz, O.1
De Bruijne, J.2
Vijgen, L.3
Verbinnen, T.4
Weegink, C.5
Van Marck, H.6
Vandenbroucke, I.7
Peeters, M.8
De Smedt, G.9
Simmen, K.10
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