A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein

Biochemical Journal

Volumn 368, Issue 1, 2002, Pages 233-242

  Clauss, Adam ^a   Lilja, Hans ^a   Lundwall, Åke ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Epididymis; Serine protease; Transcript

Indexed keywords

DNA; ENZYMES; GENES; MICROORGANISMS; TISSUE;

HOMOLOGY;

BIOCHEMISTRY;

DNA FRAGMENT; ELAFIN; EPPIN; HUMAN EPIDIDYMIS GENE PRODUCT 4; KALLIKREIN; PROTEIN; PROTEINASE INHIBITOR; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE PROTEINASE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; WHEY ACIDIC PROTEIN;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHROMOSOME 20; CODON; DNA SEQUENCE; DNA SYNTHESIS; EPIDIDYMIS; EXON; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; GENE LOCUS; HOST RESISTANCE; NERVOUS TISSUE; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TATA BOX; TESTIS; TRACHEA;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 20; DNA; EXONS; GENE EXPRESSION; GENOME, HUMAN; HUMANS; INTRONS; MILK PROTEINS; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037113123     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020869     Document Type: Article

References (34)

1. Huntington, J. A., Read, R. J. and Carrell, R. W. (2000) Structure of a serpin-protease complex shows inhibition by deformation. Nature (London) 407, 923-926
2. Ruhlmann, A., Kukla, D., Schwager, P., Bartels, K. and Huber, R. (1973) Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region. J. Mol. Biol. 77, 417-436
3. Bolognesi, M., Gatti, G., Menagatti, E., Guarneri, M., Marquart, M., Papamokos, E. and Huber, R. (1982) Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 Å resolution. Structure solution, crystallographic refinement and preliminary structural interpretation. J. Mol. Biol. 162, 839-868
4. Hennighausen, L. G. and Sippel, A. E. (1982) Mouse whey acidic protein is a novel member of the family of 'four-disulfide core' proteins. Nucleic Acids Res. 10, 2677-2684
5. Wiedow, O., Schroder, J. M., Gregory, H., Young, J. A. and Christophers, E. (1990) Elafin: An elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence. J. Biol. Chem. 285, 14791-14795
6. Thompson, R. C. and Ohlsson, K. (1985) Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc. Natl. Acad. Sci. U.S.A. 83, 6692-6696
7. Tsunemi, M., Matsuura, Y., Sakakibara, S. and Katsube, Y. (1996) Crystal structure of an elastase, specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 Å resolution. Biochemistry 35, 11570-11576
8. Grutter, M. G., Fendrich, G., Huber, R. and Bode, W. (1988) The 2.5 Å X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine α-chymotrypsin. EMBO J. 7, 345-351
9. +-ATPase from porcine intestine. Biochem. Biophys. Res. Commun. 164, 496-502
10. Coronel, C. E., San Agustin, J. and Lardy, H. A. (1990) Purification and structure of caltrin-like proteins from seminal vesicle of the guinea pig. J. Biol. Chem. 265, 6854-6859
11. Tomee, J. F., Koeter, G. H., Hiemstra, P. S. and Kauffman, H. F. (1998) Secretory leukoprotease inhibitor: A native antimicrobial protein presenting a new therapeutic option? Thorax 53, 114-116
12. Legouis, R., Hardelin, J. P., Levilliers, J., Claverie, J. M., Compain, S., Wunderle, V., Millasseau, P., Le Paslier, D., Cohen, D., Caterina, D., Bougueleret, L., Delemarrevandewaal, H., Lutfalla, G., Weissenbach, J. and Petit, C. (1991) The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell 67, 423-435
13. Lundwall, A. and Ulvsback, M. (1996) The gene of the protease inhibitor SKALP/elafin is a member of the REST gene family. Biochem. Biophys. Res. Commun. 221, 323-327
14. Lundwall, A. and Lazure, C. (1995) A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon. FEBS Lett. 374, 53-56
15. Ulvsback, M., Lazure, C., Lilja, H., Spurr, N. K., Rao, V. V., Loffler, C., Hansmann, I. and Lundwall, A. (1992) Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J. Biol. Chem. 267, 18080-18084
16. Molhuizen, H. O. F., Zeeuwen, P. L., Olde Weghuis, D., Geurts van Kessel, A. and Schalkwijk, J. (1994) Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-q13. Cytogenet. Cell Genet. 66, 129-131
17. Lundwall, A. A. and Clauss, A. (2002) Identification of a novel protease inhibitor gene that is highly expressed in the prostate. Biochem. Biophys. Res. Commun. 290, 452-456
18. Richardson, R. T., Sivashanmugam, P., Hall, S. H., Hamil, K. G., Moore, P. A., Ruben, S. M., French, F. S. and O'Rand, M. (2001) Cloning and sequencing of human Eppin: A novel family of protease inhibitors expressed in the epididymis and testis. Gene 270, 93-102
19. Kirchhoff, C., Habben, I., Ivell, R. and Krull, N. (1991) A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Biol. Reprod. 45, 350-357
20. Lundwall, A. (1996) The cloning of a rapidry evolving seminal-vesicle-transcribed gene encoding the major clot-forming protein of mouse semen. Eur. J. Biochem. 235, 424-430
21. Lundwall, A. (1998) The cotton-top tamarin carries an extended semenogelin I gene but no semenogelin II gene. Eur. J. Biochem. 255, 45-51
22. Tamechika, I., Itakura, M., Saruta, Y., Furukawa, M., Kato, A., Tachibana, S. and Hirose, S. (1996) Accelerated evolution in inhibitor domains of porcine elafin family members. J. Biol. Chem. 271, 7012-7018
23. Lundwall, A. and Olsson, A. Y. (2001) Semenoglin II gene is replaced by a truncated line 1 repeat in the cotton-top tamarin. Biol. Reprod. 65, 420-425
24. Ulvsback, M. and Lundwall, A. (1997) Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon. Eur. J. Biochem. 245, 25-31
25. Aeschlimann, D. and Paulsson, M. (1994) Transglutaminases: Protein cross-linking enzymes in tissues and body fluids. Thromb. Haemostasis 71, 402-415
26. Ohlsson, M., Rosengren, M., Tegner, H. and Ohlsson, K. (1983) Quantification of granulocyte elastase inhibitors in human mixed saliva and in pure parotid secretion. Hoppe-Seyler's Z. Physiol. Chem. 364, 1323-1328
27. Tegner, H. and Ohlsson, K. (1977) Localization of a low molecular weight protease inhibitor to tracheal and mixillary sinus mucosa. Hoppe-Seyler's Z. Physiol. Chem. 358, 425-429
28. Fink, E., Jaumann, E., Fritz, H., Ingrisch, H. and Werle, E. (1971) Protease inhibitors in human sperm prasma. Isolation using affinity chromatography and inhibition characteristics. Hoppe-Seyler's Z. Physiol. Chem. 352, 1591-1594
29. Hiemstra, P. S., Maassen, R. J., Stolk, J., Heinzel-Wieland, R., Steffens, G. J. and Dijkman, J. H. (1995) Antibacterial activity of antileukoprotease. Infect. Immun. 64, 4520-4524
30. Harvey, T. J., Hooper, J. D., Myers, S. A., Stephenson, S. A., Ashworth, L. K. and Clements, J. A. (2000) Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J. Biol. Chem. 275, 37397-37406
31. Yousef, G. M., Chang, A., Scorilas, A. and Diamandis, E. P. (2000) Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. Biochem. Biophys. Res. Commun. 276, 125-133
32. Riegman, P. H., Vlietstra, R. J., van der Korput, J. A., Romijn, J. C. and Trapman, J. (1989) Characterization of the prostate-specific antigen gene: A novel human kallikrein-like gene. Biochem. Biophys. Res. Commun. 159, 95-102
33. Lundwall, A. (1989) Characterization of the gene for prostate-specific antigen, a human glandular kallikrein. Biochem. Biophys. Res. Commun. 161, 1151-1159
34. Lilja, H. (1985) A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J. Clin. Invest. 76, 1899-1903