Neural stimulation on human bone marrow-derived mesenchymal stem cells by extremely low frequency electromagnetic fields

Biotechnology Progress

Volumn 28, Issue 5, 2012, Pages 1329-1335

  Cho, Hyunjin ^a   Seo, Young Kwon ^a   Yoon, Hee Hoon ^a   Kim, Soo Chan ^b   Kim, Sung Min ^a   Song, Kye Yong ^c   Park, Jung Keug ^a  

^a Dongguk University   (South Korea)

^b Hankyong National University   (South Korea)

^c Chung Ang University College of Medicine   (South Korea)

Author keywords

Bone marrow mesenchymal stem cells; Extremely low frequency electromagnetic field; Neural cells

Indexed keywords

ADULT STEM CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL FUNCTIONS; BONE MARROW MESENCHYMAL STEM CELLS; EXTREMELY LOW FREQUENCIES; GENE LEVELS; HUMAN BONES; NEURAL CELLS; NEURAL DIFFERENTIATIONS; NEURAL STEM CELL; NEURAL STIMULATIONS; OLIGODENDROCYTES; PLURIPOTENT STEM CELLS;

ELECTROMAGNETIC FIELD EFFECTS; ELECTROMAGNETIC FIELDS; ELECTROPHYSIOLOGY; FLOWCHARTING; PROTEINS; STEM CELLS;

CELL CULTURE;

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NERVE PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; TAU PROTEIN;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; ELECTROMAGNETIC FIELD; GENE EXPRESSION; GENETICS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; NEURAL STEM CELL;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; ELECTROMAGNETIC FIELDS; GENE EXPRESSION; HUMANS; MESENCHYMAL STROMAL CELLS; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; TAU PROTEINS;

EID: 84867390876     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1607     Document Type: Article

References (30)

1. Fossett E, Khan WS. Optimising human mesenchymal stem cell numbers for clinical application: a literature review. Stem Cells Int. 2012; 2012: 465259.
2. Sadan O, Melamed E, Offen D. Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases. Expert Opin Biol Ther. 2009; 9: 1487-1497.
3. Krampera M, Marconi S, Pasini A, Gali M, Rigotti G, Mosna F. Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus. Bone. 2007; 40: 382-390.
4. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res. 2000; 61: 364-370.
5. Jin K, Mao XO, Batteur S, Sun Y, Greenberg DA. Induction of neuronal markers in bone marrow cells: differential effects of growth factors and patterns of intracellular expression. Exp Neurol. 2003; 184: 78-89.
6. Lacy-Hulbert A, Metcalfe J, Hesketh R. Biological responses to electromagnetic fields. FASEB J. 1998; 12: 295-420.
7. Funk RH, Monsees TK. Effects of electromagnetic fields on cells: physiological and therapeutical approaches and molecular mechanisms of interaction. A review. Cells Tissues Organs. 2006; 182: 59-78.
8. Grassi C, D'Ascenzo M, Torsello A, Martinotti G, Wolf F, Cittadini A, Azzena GB. Effects of 50 Hz electromagnetic fields on voltage-gated Ca2+ channels and their role in modulation of neuroendocrine cell proliferation and death. Cell Calcium. 2004; 35: 307-315.
9. Güven M, Günay I, Ozgünen K, Zorludemir S. Effect of pulsed magnetic field on regenerating rat sciatic nerve: an in-vitro electrophysiologic study. Int J Neurosci. 2005; 115: 881-892.
10. Schwartz Z, Simon BJ, Duran MA, Barabino G, Chaudhri R, Boyan BD. Pulsed electromagnetic fields enhance BMP-2 dependent osteoblastic differentiation of human mesenchymal stem cells. J Orthop Res. 2008; 26: 1250-1255.
11. Mayer-Wagner S, Passberger A, Sievers B, Aigner J, Summer B, Schiergens TS, Jansson V, Müller PE. Effects of low frequency electromagnetic fields on the chondrogenic differentiation of human mesenchymal stem cells. Bioelectromagnetic. 2011; 32: 283-290.
12. Mathie A, Kennard LE, Veale EL. Neuronal ion channels and their sensitivity to extremely low frequency weak electric field effects. Radiat Prot Dosimetry. 2003; 106: 311-316.
13. Sieron A, Labus L, Nowak P, Cieslar G, Brus H, Durczok A, Zagzil T, Kostrzewa RM, Brus R. Alternating extremely low frequency magnetic field increases turnover of dopamine and serotonin in rat frontal cortex. Bioelectromagnetics. 2004; 25: 426-430.
14. Arias-Carrión O, Hernández-López S, Ibáñez O, Bargas J, Hernández-Cruz A, Drucker-Colín R. Neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant. J Neurosci Res. 2006; 84: 1425-1437.
15. Gerardi G, De Ninno A, Prosdocimi M, Ferrari V, Barbaro F, Mazzariol S, Bernardini D, Talpo G. Effects of electromagnetic fields of low frequency and low intensity on rat metabolism. Biomagn Res Technol. 2008; 6: 3.
16. Olivares-Banuelos T, Navarro L, Gonzalez A, Drucker-Colin R. Differentiation of chromaffin cells elicited by ELFMF modifies gene expression pattern. Cell Biol Int. 2004; 28: 273-279.
17. Lupke M, Frahm J, Lantow M, Maercker C, Remondini D, Bersani F, Simko M. Gene expression analysis of ELF-MF exposed human monocytes indicating the involvement of the alternative activation pathway. Biochim Biophys Acta. 2006; 1763: 402-412.
18. Cossarizza A, Monti D, Bersani F, Cantini M, Cadossi R, Sacchi A, Franceschi C. Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects. Biochem Biophys Res Commun. 1989; 160: 692-698.
19. Nikolova T, Czyz J, Rolletschek A, Blyszczuk P, Fuchs J, Jovtchev G, Schuderer J, Kuster N, Wobus AM. Electromagnetic fields affect transcript levels of apoptosis related genes in embryonic stem cell-derived neural progenitor cells. FASEB J. 2005; 19: 1686-1688.
20. Wu H, Ren K, Zhao W, Baojian GE, Peng S. Effect of electromagnetic fields on proliferation and differentiation of cultured mouse bone marrow mesenchymal stem cells. J Huazhong Univ Sci Technol Med Sci. 2005; 25: 185-187.
21. Huang L, Dong L, Chen Y, Qi H, Xiao D. Effects of sinusoidal magnetic field observed on cell proliferation, ion concentration, and osmolarity in two human cancer cell lines. Electromagn Biol Med. 2006; 25: 113-126.
22. Wolf FI, Torsello A, Tedesco B, Fasanella S, Boninsegna A, D'Ascenzo M, Grassi C, Azzena GB, Cittadini A. 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism. Biochim Biophys Acta. 2005; 1743: 120-129.
23. Simko M, Mattsson MO. Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: Possible immune cell activation. J Cell Biochem. 2004; 93: 83-92.
24. Piacentini R, Ripoli C, Mezzogori D, Azzena GB, Grassi C. Extremely low-frequency electromagnetic fields promote in vitro neurogenesis via upregulation of Cav1-channel activity. J Cell Physiol. 2008; 215: 129-139.
25. Motoyama M, Deie M, Kanaya A, Nishimori M, Miyamoto A, Yanada S, Adachi N, Ochi M. In vitro cartilage formation using TGF-beta-immobilized magnetic beads and mesenchymal stem cell-magnetic bead complexes under magnetic field conditions. J Biomed Mater Res A. 2010; 92: 196-204.
26. Wislet-Gendebien S, Hans G, Leprince P, Rigo JM, Moonen G, Rogister B. Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype. Stem Cells. 2005; 23: 392-402.
27. Sun S, Titushkin I, Cho M. Regulation of mesenchymal stem cell adhesion and orientation in 3D collagen scaffold by electrical stimulus. Bioelectrochemistry. 2006; 69: 133-141.
28. Morgado-Valle C, Verdugo-Diaz L, Garcia DE, Morales-Orozco C, Drucker-Colin R. The role of voltage-gated Ca2+ channels in neurite growth of cultured chromaffin cells induced by extremely low frequency (ELF) magnetic field stimulation. Cell Tissue Res. 1998; 291: 217-230.
29. Tonini R, Baroni MD, Masala E, Micheletti M, Ferroni A, Mazzanti M. Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. Biophys J. 2001; 81: 2580-2589.
30. Mantamadiotis T, Papalexis N, Dworkin S. CREB signalling in neural stem/progenitor cells: recent developments and the implications for brain tumour biology. Bioessays. 2012; 34: 293-300.