Hypothermia, hypotension, hypersomnia, and obesity associated with hypothalamic lesions in a patient positive for the anti-aquaporin 4 antibody: A case report and literature review

Archives of Neurology

Volumn 69, Issue 10, 2012, Pages 1355-1359

  Suzuki, Keisuke ^a   Nakamura, Toshiki ^b   Hashimoto, Kenichi ^a   Miyamoto, Masayuki ^a   Komagamine, Tomoko ^a   Nagashima, Takahide ^a   Izawa, Naoki ^a   Kanbayashi, Takashi ^c   Takahashi, Toshiyuki ^d   Hirata, Koichi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Rehabilitation Amakusa Hospital   (Japan)

^c AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4 ANTIBODY; FOLLITROPIN; HYDROCORTISONE SODIUM SUCCINATE; IMMUNOGLOBULIN G; LUTEINIZING HORMONE; METHYLPREDNISOLONE SODIUM SUCCINATE; MODAFINIL; OREXIN; PREDNISOLONE; VASOPRESSIN;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ARTICLE; BRADYCARDIA; CASE REPORT; CATAPLEXY; COGNITIVE DEFECT; DAYTIME SOMNOLENCE; DEMYELINATING DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISORIENTATION; ELECTROENCEPHALOGRAPHY; FEMALE; FOLLITROPIN BLOOD LEVEL; HUMAN; HYPERSOMNIA; HYPONATREMIA; HYPOTENSION; HYPOTHALAMUS LESION; HYPOTHERMIA; INAPPROPRIATE VASOPRESSIN SECRETION; LETHARGY; LUTEINIZING HORMONE BLOOD LEVEL; MEMORY DISORDER; NARCOLEPSY; NEUROMYELITIS OPTICA SPECTRUM DISEASE; NEUROMYELITIS OPTICA SPECTRUM DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PLEOCYTOSIS; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; SERUM OSMOLARITY;

ANTIBODIES, ANTI-IDIOTYPIC; AQUAPORIN 4; DISORDERS OF EXCESSIVE SOMNOLENCE; FEMALE; HUMANS; HYPOTENSION; HYPOTHALAMUS; HYPOTHERMIA; MAGNETIC RESONANCE IMAGING; OBESITY; YOUNG ADULT;

EID: 84867385326     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2012.300     Document Type: Article

References (16)

1. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol. 2007;6(9):805-815. (Pubitemid 47238676)
2. Kim W, Kim SH, Lee SH, Li XF, Kim HJ. Brain abnormalities as an initial manifestation of neuromyelitis optica spectrum disorder. Mult Scler. 2011;17(9):1107-1112.
3. Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA. Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol. 2006;63(7):964-968. (Pubitemid 44036298)
4. Chan KH, Tse CT, Chung CP, et al. Brain involvement in neuromyelitis optica spectrum disorders. Arch Neurol. 2011;68(11):1432-1439.
5. Poppe AY, Lapierre Y, Melançon D, et al. Neuromyelitis optica with hypothalamic involvement. Mult Scler. 2005;11(5):617-621. (Pubitemid 41387709)
6. Carlander B, Vincent T, Le Floch A, Pageot N, Camu W, Dauvilliers Y. Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes. J Neurol Neurosurg Psychiatry. 2008;79(3):333-334. (Pubitemid 351303398)
7. Nozaki H, Shimohata T, Kanbayashi T, et al. A patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia, reduced orexin (hypocretin) level, and symmetrical hypothalamic lesions. Sleep Med. 2009;10(2):253-255.
8. Kanbayashi T, Shimohata T, Nakashima I, et al. Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications. Arch Neurol. 2009;66(12):1563-1566.
9. Baba T, Nakashima I, Kanbayashi T, et al. Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody. J Neurol. 2009;256(2):287-288.
10. Viegas S, Weir A, Esiri M, et al. Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. J Neurol Neurosurg Psychiatry. 2009;80(6):679-682.
11. Samart K, Phanthumchinda K. Neuromyelitis optica with hypothalamic involvement: a case report. J Med Assoc Thai. 2010;93(4):505-509.
12. Sekiguchi T, Ishibashi S, Kubodera T, et al. Anhidrosis associated with hypothalamic lesions related to anti-aquaporin 4 autoantibody. J Neurol. 2011;258(12):2293-2295.
13. Nakajima H, Fujiki Y, Ito T, Kitaoka H, Takahashi T. Anti-aquaporin-4 antibody-positive neuromyelitis optica presenting with syndrome of inappropriate antidiuretic hormone secretion as an initial manifestation. Case Rep Neurol. 2011;3(3):263-267.
14. Nakano T, Fujimoto T, Fukuda Y, Takahashi T, Kanbayashi T. Neuromyelitis optica with syndrome of inappropriate secretion of antidiuretic hormone and hypersomnia associated with bilateral hypothalamic lesions: a case report [in Japanese]. Rinsho Shinkeigaku. 2011;51(8):599-602.
15. Deguchi K, Kono S, Deguchi S, et al. A patient with anti-aquaporin 4 antibody presenting hypersomnolence as the initial symptom and symmetrical hypothalamic lesions. J Neurol Sci. 2012;312(1-2):18-20.
16. Iorio R, Lucchinetti CF, Lennon VA, et al. Syndrome of inappropriate antidiuresis may herald or accompany neuromyelitis optica. Neurology. 2011;77(17):1644-1646.