Activated hypothalamic pituitary adrenal axis in patients with metabolic syndrome

Hormone and Metabolic Research

Volumn 44, Issue 11, 2012, Pages 839-844

  Kazakou, P ^a   Kyriazopoulou, V ^a   Michalaki, M ^a   Ierodiakonou, V ^a   Psyrogiannis, A ^a   Habeos, I ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

ACTH; cortisol; glucocorticoids; metabolic syndrome

Indexed keywords

C PEPTIDE; CORTICOTROPIN; DEXAMETHASONE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCORTISONE; INSULIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DEXAMETHASONE SUPPRESSION TEST; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERCORTISOLISM; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADRENOCORTICOTROPIC HORMONE; ADULT; C-PEPTIDE; CASE-CONTROL STUDIES; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; UP-REGULATION;

EID: 84867336197     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1311632     Document Type: Article

References (41)

1. Grundy S. M., Cleeman J. I., Daniels S. R., Donato K. A., Eckel R. H., Franklin B. A., Gordon D. J., Krauss R. M., Savage P. J., Smith S. C. Jr, Spertus J. A., Costa F. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation: 2005; 112 2735 2752
2. Anagnostis P., Athyros V. G., Tziomalos K., Karagiannis A., Mikhailidis D. P. Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab: 2009; 94 2692 2701
3. Wajchenberg B. L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev: 2000; 21 697 738
4. Pasquali R., Biscotti D., Spinucci G., Vicennati V., Genazzani A. D., Sgarbi L., Casimirri F. Pulsatile secretion of ACTH and cortisol in premenopausal women: effect of obesity and body fat distribution. Clin Endocrinol (Oxf): 1998; 48 603 612
5. Andrews R. C., Walker B. R. Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Lond): 1999; 96 513 523
6. Dinneen S., Alzaid A., Miles J., Rizza R. Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. J Clin Invest: 1993; 92 2283 2290
7. Björntorp P., Rosmond R. Hypothalamic origin of the metabolic syndrome X. Ann N Y Acad Sci: 1999; 892 297 307
8. Chrousos G. P. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J Obes Relat Metab Disord: 2000; 24 02 S50 S55
9. Epel E. S., McEwen B., Seeman T., Matthews K., Castellazzo G., Brownell K. D., Bell J., Ickovics J. R. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med: 2000; 62 623 632
10. Chalew S., Nagel H., Shore S. The hypothalamic-pituitary-adrenal axis in obesity. Obes Res: 1995; 3 371 382
11. Rosmond R., Dallman M. F., Björntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab: 1998; 83 1853 1859
12. Epel E. E., Moyer A. E., Martin C. D., Macary S., Cummings N., Rodin J., Rebuffe-Scrive M. Stress-induced cortisol, mood, and fat distribution in men. Obes Res: 1999; 7 9 15
13. Vicennati V., Ceroni L., Gagliardi L., Pagotto U., Gambineri A., Genghini S., Pasquali R. Response of the hypothalamic-pituitary-adrenal axis to small dose arginine-vasopressin and daily urinary free cortisol before and after alprazolam pre-treatment differs in obesity. J Endocrinol Invest: 2004; 27 541 547
14. Leal A. M., Moreira A. C. Food and the circadian activity of the hypothalamic-pituitary-adrenal axis. Braz J Med Biol Res: 1997; 30 1391 1405
15. Korbonits M., Trainer P. J., Nelson M. L., Howse I., Kopelman P. G., Besser G. M., Grossman A. B., Svec F. Differential stimulation of cortisol and dehydroepiandrosterone levels by food in obese and normal subjects: relation to body fat distribution. Clin Endocrinol (Oxf): 1996; 45 699 706
16. Vicennati V., Ceroni L., Gagliardi L., Gambineri A., Pasquali R. Comment: response of the hypothalamic-pituitary-adrenocortical axis to high-protein/fat and high-carbohydrate meals in women with different obesity phenotypes. J Clin Endocrinol Metab: 2002; 87 3984 3988
17. Obesity: preventing and managing the global epidemic Report of a WHO consultation. World Health Organ Tech Rep Ser: 2000; 894 i-xii 1 253
18. Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia: 1985; 28 412 419
19. Katz A., Nambi S. S., Mather K., Baron A. D., Follmann D. A., Sullivan G., Quon M. J. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab: 2000; 85 2402 2410
20. Matsuda M., DeFronzo R. A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care: 1999; 22 1462 1470
21. Bonora E., Kiechl S., Willeit J., Oberhollenzer F., Egger G., Targher G., Alberiche M., Bonadonna R. C., Muggeo M. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes: 1998; 47 1643 1649
22. Nakai Y., Nakaishi S., Kishimoto H., Seino Y., Nagasaka S., Sakai M., Taniguchi A. The threshold value for insulin resistance on homeostasis model assessment of insulin sensitivity. Diabet Med: 2002; 19 346 347
23. Ascaso J. F., Pardo S., Real J. T., Lorente R. I., Priego A., Carmena R. Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism. Diabetes Care: 2003; 26 3320 3325
24. Bergman R., Hücking K., Watanabe R. Measuring insulin action in vivo. Int Textbook Diabetes Mellitus: 2004; 16 303 318
25. Follenius M., Brandenberger G., Hietter B. Diurnal cortisol peaks and their relationships to meals. J Clin Endocrinol Metab: 1982; 55 757 761
26. Gibson E. L., Checkley S., Papadopoulos A., Poon L., Daley S., Wardle J. Increased salivary cortisol reliably induced by a protein-rich midday meal. Psychosom Med: 1999; 61 214 224
27. Al-Damluji S., Iveson T., Thomas J. M., Pendlebury D. J., Rees L. H., Besser G. M. Food-induced cortisol secretion is mediated by central alpha-1 adrenoceptor modulation of pituitary ACTH secretion. Clin Endocrinol (Oxf): 1987; 26 629 636
28. Ishizuka B., Quigley M. E., Yen S. S. Pituitary hormone release in response to food ingestion: evidence for neuroendocrine signals from gut to brain. J Clin Endocrinol Metab: 1983; 57 1111 1116
29. Reynolds R. M., Walker B. R., Syddall H. E., Whorwood C. B., Wood P. J., Phillips D. I. Elevated plasma cortisol in glucose-intolerant men: differences in responses to glucose and habituation to venepuncture. J Clin Endocrinol Metab: 2001; 86 1149 1153
30. Reynolds R. M., Syddall H. E., Walker B. R., Wood P. J., Phillips D. I. Predicting cardiovascular risk factors from plasma cortisol measured during oral glucose tolerance tests. Metabolism: 2003; 52 524 527
31. Rodman H. M., Bleicher S. J. Plasma cortisol during normal glucose tolerance. Metabolism: 1973; 22 745 748
32. Sober A. J., Ruder H. J., Sode J. Adrenal activity during normal glucose tolerance. Acta Endocrinol (Copenh): 1977; 84 115 118
33. Hautanen A., Adlercreutz H. Altered adrenocorticotropin and cortisol secretion in abdominal obesity: implications for the insulin resistance syndrome. J Intern Med: 1993; 234 461 469
34. Cakir M., Sari R., Tosun O., Karayalcin U. Cortisol levels during an oral glucose tolerance test in lean and obese women. Endocr Res: 2005; 31 213 218
35. Fernández-Real J. M., Ricart W., Casamitjana R. Lower cortisol levels after oral glucose in subjects with insulin resistance and abdominal obesity. Clin Endocrinol (Oxf): 1997; 47 583 588
36. Beuschlein F., Borgemeister M., Schirra J., Göke B., Fassnacht M., Arlt W., Allolio B., Reincke M. Oral glucose tolerance testing but not intravenous glucose administration uncovers hyper-responsiveness of hypothalamo-pituitary-adrenal axis in patients with adrenal incidentalomas. Clin Endocrinol (Oxf): 2000; 52 617 623
37. Ljung T., Andersson B., Bengtsson B. A., Björntorp P., Marin P. Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes Res: 1996; 4 277 282
38. Duclos M., Gatta B., Corcuff J. B., Rashedi M., Pehourcq F., Roger P. Fat distribution in obese women is associated with subtle alterations of the hypothalamic-pituitary-adrenal axis activity and sensitivity to glucocorticoids. Clin Endocrinol (Oxf): 2001; 55 447 454
39. Pasquali R., Ambrosi B., Armanini D., Cavagnini F., Uberti E. D., Del Rio G., de Pergola G., Maccario M., Mantero F., Marugo M., Rotella C. M., Vettor R. Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study. J Clin Endocrinol Metab: 2002; 87 166 175
40. Duclos M., Marquez Pereira P., Barat P., Gatta B., Roger P. Increased cortisol bioavailability, abdominal obesity, and the metabolic syndrome in obese women. Obes Res: 2005; 13 1157 1166
41. Fruehwald-Schultes B., Kern W., Born J., Fehm H. L., Peters A. Hyperinsulinemia causes activation of the hypothalamus-pituitary-adrenal axis in humans. Int J Obes Relat Metab Disord: 2001; 25 01 S38 S40