Oral glucose tolerance testing but not intravenous glucose administration uncovers hyper-responsiveness of hypothalamo-pituitary-adrenal axis inpatients with adrenal incidentalomas

Clinical Endocrinology

Volumn 52, Issue 5, 2000, Pages 617-623

  Beuschlein, Felix ^b   Borgemeister, M ^c   Schirra, J ^c   Goke B ^a   Fassnacht, M ^c   Arlt, W ^c   Allolio, B ^c   Reincke, M ^c  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE; HYDROCORTISONE;

ADRENAL CORTEX ADENOMA; ADULT; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; FOOD INTAKE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

ADENOMA; ADMINISTRATION, ORAL; ADRENAL CORTEX NEOPLASMS; ADRENOCORTICOTROPIC HORMONE; ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; CASE-CONTROL STUDIES; FEMALE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; INSULIN RESISTANCE; MALE; PITUITARY-ADRENAL SYSTEM;

EID: 0034118742     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.01006.x     Document Type: Article

References (35)

1. Abrams, H.L., Siegelman, S.S., Adams, D.F., Sanders, R., Finberg, H.J., Hessel, S.J. & McNeil, B.J. (1982) Computed tomography versus ultrasound of the adrenal gland: a prospective study. Radiology, 143, 121-128.
2. Al-Damluji, S., Iveson, T., Thomas, J.M., Pendlebury, D.J., Rees, L.H. & Besser, G.M. (1987) Food induced cortisol secretion is mediated by central alpha-1 adrenoceptor modulation of pituitary ACTH secretion. Clinical Endocrinology, 26, 629-636.
3. Angeli, A., Osella, G., Ali, A. & Terzolo, M. (1997) Adrenal incidentaloma: an overview of clinical and epidemiological data from the National Italian Study Group. Hormone Research, 47, 279-283.
4. Cameron, O.G., Kronfol, Z., Greden, J.F. & Carrol, B.J. (1984) Hypothalamic-pituitary-adrenocortical activity in patients with diabetes mellitus. Archives of General Psychiatry, 41, 1090-1095.
5. Chabre, O., Liakos, P., Vivier, J., Chaffanjon, P., Labat-Moleur, F., Martine, M., Bottari, S.P., Bachelot, I., Chambraz, E.M., Defaye, G. & Feige, J. (1998) Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: Insights into hormonal control of adrenocortical tumorigenesis. Journal of Clinical Endocrinology and Metabolism, 83, 3134-3143.
6. Crapo, L. (1979) Cushing's syndrome: a review of diagnostic tests. Metabolism, 28, 955-977.
7. De Herder, W.W., Hofland, L.J., Usdin, T.B., de Jong, F.H., Uitterlinden, P., van Koetsveld, P., Mezey, E., Bonner, T.I., Bonjer, H.J. & Lamberts, S.W. (1996) Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells. Journal of Clinical Endocrinology and Metabolism, 81, 3168-3172.
8. Dunkelmann, S.S., Fairburst, B. & Plager, J. (1964) Cortisol metabolism in obesity. Journal of Clinical Endocrinology and Metabolism, 24, 832-841.
9. Fehmann, H.C., Göke, R. & Göke, B. (1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocrine Reviews, 16, 390-410.
10. Fernández-Real, J.M., Ricart, W. & Casamitjana, R. (1997) Lower cortisol levels after oral glucose in subjects with insuline resistance and abdominal obesity. Clinical Endocrinology, 47, 583-588.
11. Follenius, M., Brandenberger, G. & Hietter, B. (1982) Diurnal cortisol peaks and their relationship to meals. Journal of Clinical Endocrinology and Metabolism, 55, 757-761.
12. Glass, A.R., Burman, K.D., Dahms, W.T. & Boehm, T.M. (1981) Endocrine function in human obesity. Metabolism, 30, 89-104.
13. Hensen, J., Buhl, M., Bahr, V. & Oelkers, W. (1990) Endocrine activity of the 'silent' adrenocortical adenoma is uncovered by response to corticotropin-releasing hormone. Klinische Wochenschrift, 68, 608-614.
14. Ishizuka, B., Quigley, M.E. & Yen, S.S.C. (1983) Pituitary hormone release in response to food ingestion: Evidence for neuroendocrine signals from gut to brain. Journal of Clinical Endocrinology and Metabolism, 57, 1111-1116.
15. Jung, R. (1984) Endocrinological aspects of obesity. Journal of Clinical Endocrinology and Metabolism, 13, 597-612.
16. Kopelman, P.G., Grossman, A., Lavender, P., Besser, G.M., Rees, L.H. & Coy, D. (1988) The cortisol response to corticotrophin-releasing factor is blunted in obesity. Clinical Endocrinology, 28, 15-18.
17. Korbonits, M., Trainer, P.J., Little, J.A., Edwards, R., Kopelman, P.G., Besser, G.M., Svec, F. & Grossman, A.B. (1997) Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clinical Endocrinology, 46, 751 -757.
18. Korbonits, M., Trainer, P.J., Nelson, M.L., Howse, I., Kopelman, P.G., Besser, G.M., Grossman, A.B. & Svec, F. (1996) Differential stimulation of cortisol and dehydroepiandrosterone levels by food in obese and normal subjects: relation to body fat distribution. Clinical Endocrinology, 45, 699-706.
19. Lacroix, A., Bolté, E., Tremblay, J., Dupré, J., Poitras, P., Fournier, H., Garon, J., Garrel, D., Bayard, F., Taillefer, R., Flanagan, R. & Hamet, P. (1992) Gastric inhibitory polypeptide-dependent cortisol hypersecretion - a new cause of Cushing's syndrome. New England Journal of Medicine, 327, 974-980.
20. Lebrethon, M.C., Avallet, O., Reznik, Y., Archambeaud, F., Combes, J., Usdin, T.B., Narboni, G., Mahoudeau, J. & Saez, J.M. (1998) Food-dependent Cushing's syndrome: characterization and functional role of gastric inhibitory polypeptide receptor in the adrenals of three patients. Journal of Clinical Endocrinology and Metabolism, 83, 4514-4519.
21. Mantero, F., Masini, A.M., Opocher, G., Giovagnetti, M. & Arnaldi, G. (1997) Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group. Hormone Research, 47, 284-289.
22. Marin, P., Darin, N., Amemiya, T., Andersson, B., Jern, S. & Bjorntorp, P. (1992) Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism, 41, 882-866.
23. McLeod, M.K., Thompson, N.W., Gross, M.D., Bondeson, A.G. & Bondeson, L. (1990) Sub-clinical Cushing's syndrome in patients with adrenal incidentalomas. Pitfalls in diagnosis and management. Annals of Surgery, 56, 398-403.
24. Migeon, C.J., Green, O.C. & Eckert, J.P. (1963) Study of adrenocorticoid function in obesity. Journal of Clinical Endocrinology and Metabolism, 23, 718-739.
25. National Diabetes Data Group. (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes, 28, 1039-1057.
26. Quigley, M.E. & Yen, S.S.C. (1972) A mid-day surge in cortisol levels. Journal of Clinical Endocrinology and Metabolism, 33, 945-947.
27. Reincke, M., Nieke, J., Krestin, G.P., Saeger, W., Allolio, B. & Winkelmann, W. (1992) Preclinical Cushing's syndrome in adrenal 'incidentalomas': comparison with adrenal Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 75, 826-832.
28. Reznik, Y., Allali-Zerah, V., Chayvialle, J.A., Leroyer, R., Leymarie, P., Travert, G., Lebrethon, M.C., Budi, I., Balliere, A.M. & Mahoudeau, J. (1992) Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide. New England Journal of Medicine, 327, 981-986.
29. Rosmond, R., Dallman, M.F. & Bjorntorp, P. (1998) Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. Journal of Clinical Endocrinology and Metabolism, 83, 1853-1859.
30. Sahpiro, E.T., Polonsky, K.S., Copinschi, G., Bosson, D., Till, H., Blackman, J., Lewis, G. & Van-Cauter, E. (1991) Nocturnal elevation of glucose levels during fasting in non-insulin-dependent diabetes. Journal of Clinical Endocrinology and Metabolism, 72, 444-454.
31. Saito, M., Kato, H., Suda, M. & Yugari, Y. (1981) Parenteral feeding abolishes the circadian adrenocortical rhythm in rats. Experientia, 37, 754-755.
32. Schirra, J., Katschinski, M., Weidmann, C, Schäfer, T., Wank, U., Arnold, R. & Göke, B. (1996) Gastric emptying and release of incretine hormones after glucose ingestion in humans. Journal of Clinical Investigations, 97, 92-103.
33. Strain, G.W., Zumoff, B., Kream, J., Strain, J.J., Levin, J. & Fukushima, D. (1982) Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol. Metabolism, 31, 209-212.
34. Weitzman, E.D., Fukushima, D., Nogeire, C., Roffwarg, H., Gallagher, T.F. & Hellman, L. (1971) Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. Journal of Clinical Endocrinology and Metabolism, 33, 14-22.
35. Zelissen, P.M., Koppeschaar, H.P., Erkelens, D.W. & Thijssen, J.H. (1991) Beta-endorphin and adrenocortical function in obesity. Clinical Endocrinology, 35, 369-372.