Collagen XVII is expressed in malignant but not in benign melanocytic tumors and it can mediate antibody induced melanoma apoptosis

Histochemistry and Cell Biology

Volumn 138, Issue 4, 2012, Pages 653-667

  Krenacs, T ^a   Kiszner, G ^a   Stelkovics, E ^b   Balla, P ^a   Teleki, I ^a   Nemeth, I ^c   Varga, E ^c   Korom, I ^c   Barbai, T ^a   Plotar, V ^d   Timar, J ^a   Raso, E ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b BAY ZOLTÁN NONPROFIT LTD FOR APPLIED RESEARCH   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

^d NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

Antibody induced apoptosis; Borderline dysplastic lesions; Collagen XVII endodomain; Malignant melanoma; Melanoma invasion

Indexed keywords

ANTIBODY; COLLAGEN; COLLAGEN XVII; ECTODOMAIN ANTIBODY; ENDODOMAIN ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DETECTION; APOPTOSIS; ARTICLE; BENIGN TUMOR; CELL PROLIFERATION; FEMALE; GENE SEQUENCE; HEMIDESMOSOME; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; MELANOCYTE; MELANOCYTIC NEVUS; MELANOMA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINDLE CELL CARCINOMA; SQUAMOUS CELL CARCINOMA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; APOPTOSIS; AUTOANTIGENS; BLOTTING, WESTERN; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MALE; MELANOCYTES; MELANOMA; MIDDLE AGED; NON-FIBRILLAR COLLAGENS; POLYMERASE CHAIN REACTION;

CELASTRINA LADON;

EID: 84867332179     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-012-0981-9     Document Type: Article

References (48)

1. Alonso SR, Ortiz P, Pollan M, Perez-Gomez B, Sanchez L, Acuna MJ, Pajares R, Martinez-Tello FJ, Hortelano CM, Piris MA, Rodriguez-Peralto JL (2004) Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study. Am J Pathol 164:193-203
2. Balla P, Moskovszky L, Sapi Z, Forsyth R, Knowles H, Athanasou NA, Szendroi M, Kopper L, Rajnai H, Pinter F, Petak I, Benassi MS, Picci P, Conti A, Krenacs T (2011) Epidermal growth factor receptor signalling contributes to osteoblastic stromal cell proliferation, osteoclastogenesis and disease progression in giant cell tumour of bone. Histopathology 59:376-389
3. Bauer JW, Schaeppi H, Kaserer C, Hantich B, Hintner H (2001) Large melanocytic nevi in hereditary epidermolysis bullosa. J Am Acad Dermatol 44:577-584
4. Bichel J, Metze D, Bruckner-Tuderman L, Stander S (2001) Large melanocytic nevi in generalized atrophic benign epidermolysis bullosa (epidermolysis bullosa nevi). Hautarzt 52:812-816
5. Borradori L, Sonnenberg A (1999) Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol 112:411-418
6. Budinger L, Borradori L, Yee C, Eming R, Ferencik S, Grosse-Wilde H, Merk HF, Yancey K, Hertl M (1998) Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls. J Clin Invest 102:2082-2089
7. Carlson JA, Ross JS, Slominski A, Linette G, Mysliborski J, Hill J, Mihm M Jr (2005) Molecular diagnostics in melanoma. J Am Acad Dermatol 52:743-775 (quiz 775-748)
8. Cohen-Knafo E, al Saati T, Aziza J, Ralfkiaer E, Selves J, Gorguet B, Delsol G (1995) Production and characterisation of an antimelanoma monoclonal antibody KBA.62 using a new melanoma cell line reactive on paraffin wax embedded sections. J Clin Pathol 48:826-831
9. Crowson AN, Magro CM, Mihm MC (2006) Prognosticators of melanoma, the melanoma report, and the sentinel lymph node. Mod Pathol 19(Suppl 2):S71-S87
10. de Vries TJ, Smeets M, de Graaf R, Hou-Jensen K, Brocker EB, Renard N, Eggermont AM, van Muijen GN, Ruiter DJ (2001) Expression of gp100, MART-1, tyrosinase, and S100 in paraffinembedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group. J Pathol 193:13-20
11. Franzke CW, Tasanen K, Borradori L, Huotari V, Bruckner-Tuderman L (2004) Shedding of collagen XVII/BP180: structural motifs influence cleavage from cell surface. J Biol Chem 279:24521-24529
12. Franzke CW, Bruckner P, Bruckner-Tuderman L (2005) Collagenous transmembrane proteins: recent insights into biology and pathology. J Biol Chem 280:4005-4008
13. Franzke CW, Bruckner-Tuderman L, Blobel CP (2009) Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9. J Biol Chem 284:23386-23396
14. Giblin AV, Thomas JM (2007) Incidence, mortality and survival in cutaneous melanoma. J Plast Reconstr Aesthet Surg 60:32-40
15. Giricz O, Lauer JL, Fields GB (2010) Variability in melanoma metalloproteinase expression profiling. J Biomol Tech 21:194-204
16. Gollob JA, Sciambi CJ, Huang Z, Dressman HK (2005) Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma. Cancer Res 65:8869-8877
17. Ha L, Merlino G, Sviderskaya EV (2008) Melanomagenesis: overcoming the barrier of melanocyte senescence. Cell Cycle 7:1944-1948
18. Hofmann SC, Voith U, Schonau V, Sorokin L, Bruckner-Tuderman L, Franzke CW (2009) Plasmin plays a role in the in vitro generation of the linear IgA dermatosis antigen LADB97. J Invest Dermatol 129:1730-1739
19. Hopkinson SB, Findlay K, deHart GW, Jones JC (1998) Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure. J Invest Dermatol 111:1015-1022
20. Huttenbach Y, Prieto VG, Reed JA (2002) Desmoplastic and spindle cell melanomas express protein markers of the neural crest but not of later committed stages of Schwann cell differentiation. J Cutan Pathol 29:562-568
21. Jangi SM, Ruiz-Larrea MB, Nicolau-Galmes F, Andollo N, Arroyo-Berdugo Y, Ortega-Martinez I, Diaz-Perez JL, Boyano MD (2008) Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2? homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors. Carcinogenesis 29:500-509
22. King R, Googe PB, Weilbaecher KN, Mihm MC Jr, Fisher DE (2001) Microphthalmia transcription factor expression in cutaneous benign, malignant melanocytic, and nonmelanocytic tumors. Am J Surg Pathol 25:51-57
23. Kitajima Y, Hirako Y, Owaribe K, Mori S, Yaoita H (1994) Antibody-binding to the 180-kD bullous pemphigoid antigens at the lateral cell surface causes their internalization and inhibits their assembly at the basal cell surface in cultured keratinocytes. J Dermatol 21:838-846
24. Krenacs T, Krenacs L, Raffeld M (2010) Multiple antigen immunostaining procedures. Methods Mol Biol 588:281-300
25. Ladanyi A, Timar J, Bocsi J, Tovari J, Lapis K (1995) Sex-dependent liver metastasis of human melanoma lines in SCID mice. Melanoma Res 5:83-86
26. Lanschuetzer CM, Emberger M, Hametner R, Klausegger A, Pohla-Gubo G, Hintner H, Bauer JW (2003) Pathogenic mechanisms in epidermolysis bullosa naevi. Acta Derm Venereol 83:332-337
27. Lin MS, Gharia MA, Swartz SJ, Diaz LA, Giudice GJ (1999) Identification and characterization of epitopes recognized by T lymphocytes and autoantibodies from patients with herpes gestationis. J Immunol 162:4991-4997
28. Lin MS, Fu CL, Giudice GJ, Olague-Marchan M, Lazaro AM, Stastny P, Diaz LA (2000) Epitopes targeted by bullous pemphigoid T lymphocytes and autoantibodies map to the same sites on the bullous pemphigoid 180 ectodomain. J Invest Dermatol 115: 955-961
29. Magro CM, Crowson AN, Mihm MC (2006) Unusual variants of malignant melanoma. Mod Pathol 19(Suppl 2):S41-S70
30. Moore MW, Gasparini R (2011) FISH as an effective diagnostic tool for the management of challenging melanocytic lesions. Diagn Pathol 6:76
31. Nishie W, Lamer S, Schlosser A, Licarete E, Franzke CW, Hofmann SC, Jackow J, Sitaru C, Bruckner-Tuderman L (2010) Ectodomain shedding generates neoepitopes on collagen XVII, the major autoantigen for bullous pemphigoid. J Immunol 185:4938-4947
32. Nishie W, Kiritsi D, Nystrom A, Hofmann SC, Bruckner-Tuderman L (2011) Dynamic interactions of epidermal collagen XVII with the extracellular matrix: laminin 332 as a major binding partner. Am J Pathol 179:829-837
33. Ogawa H, Sakuma M, Morioka S, Kitamura K, Sasai Y, Imamura S, Inaba Y (1995) The incidence of internal malignancies in pemphigus and bullous pemphigoid in Japan. J Dermatol Sci 9:136-141
34. Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW (2008) Immunohistochemical characteristics of melanoma. J Cutan Pathol 35:433-444
35. Parikka M, Kainulainen T, Tasanen K, Vaananen A, Bruckner-Tuderman L, Salo T (2003) Alterations of collagen XVII expression during transformation of oral epithelium to dysplasia and carcinoma. J Histochem Cytochem 51:921-929
36. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108
37. Pinon P, Wehrle-Haller B (2011) Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation. Pigment Cell Melanoma Res 24:282-294
38. Qiao H, Shibaki A, Long HA, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan JR (2009) Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signaling. J Invest Dermatol 129:2288-2295
39. Seppanen A, Autio-Harmainen H, Alafuzoff I, Sarkioja T, Veijola J, Hurskainen T, Bruckner-Tuderman L, Tasanen K, Majamaa K (2006) Collagen XVII is expressed in human CNS neurons. Matrix Biol 25:185-188
40. Seppanen A, Suuronen T, Hofmann SC, Majamaa K, Alafuzoff I (2007) Distribution of collagen XVII in the human brain. Brain Res 1158:50-56
41. Slominski A (2002) Coming of age of melanogenesis-related proteins. Arch Pathol Lab Med 126:775-777
42. Stelkovics E, Korom I, Marczinovits I, Molnar J, Rasky K, Raso E, Ficsor L, Molnar B, Kopper L, Krenacs T (2008) Collagen XVII/BP180 protein expression in squamous cell carcinoma of the skin detected with novel monoclonal antibodies in archived tissues using tissue microarrays and digital microscopy. Appl Immunohistochem Mol Morphol 16:433-441
43. Suzuki M, Murata S, Yaoita H, Nakagawa H (2002) An antibody to BP 180 kDa antigen is able to induce an increase of intracellular Ca2? concentration in DJM-1 (human squamous cell carcinoma) cells. Autoimmunity 35:271-276
44. Szabad G, Kormos B, Pivarcsi A, Szell M, Kis K, Kenderessy Szabo A, Dobozy A, Kemeny L, Bata-Csorgo Z (2007) Human adult epidermal melanocytes cultured without chemical mitogens express the EGF receptor and respond to EGF. Arch Dermatol Res 299:191-200
45. Tasanen K, Floeth M, Schumann H, Bruckner-Tuderman L (2000) Hemizygosity for a glycine substitution in collagen XVII: unfolding and degradation of the ectodomain. J Invest Dermatol 115:207-212
46. Vergier B, Prochazkova-Carlotti M, de la Fouchardiere A, Cerroni L, Massi D, De Giorgi V, Bailly C, Wesselmann U, Karlseladze A, Avril MF, Jouary T, Merlio JP (2011) Fluorescence in situ hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases. Mod Pathol 24:613-623
47. Yamada T, Endo R, Tsukagoshi K, Fujita S, Honda K, Kinoshita M, Hasebe T, Hirohashi S (1996) Aberrant expression of a hemidesmosomal protein, bullous pemphigoid antigen 2, in human squamous cell carcinoma. Lab Invest 75:589-600
48. Zone JJ, Taylor TB, Meyer LJ, Petersen MJ (1998) The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen, BPAg2. J Invest Dermatol 110:207-210