-
1
-
-
77956447756
-
-
IARC Press, Lyon
-
Jaffe ES, Harris NL, Vardiman JW Stein H (2001) World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues, vol 352. IARC Press, Lyon, p 85
-
(2001)
World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues
, vol.352
, pp. 85
-
-
Jaffe, E.S.1
Harris, N.L.2
Vardiman, J.W.3
Stein, H.4
-
2
-
-
37649025954
-
Incidence, clinical characteristics and survival of malignant lymphomas: A population-based study from a cancer registry in northern Italy
-
Luminari S, Cesaretti M, Rashid I, Mammi C, Montanini A, Barbolini E et al (2007) Incidence, clinical characteristics and survival of malignant lymphomas: a population-based study from a cancer registry in northern Italy. Hematol Oncol 25:189-197
-
(2007)
Hematol Oncol
, vol.25
, pp. 189-197
-
-
Luminari, S.1
Cesaretti, M.2
Rashid, I.3
Mammi, C.4
Montanini, A.5
Barbolini, E.6
-
3
-
-
0038394537
-
Acyclic N-(azacycloalkyl) bisindolylmaleimides: Isozyme selective inhibitors of PKC-beta
-
Faul MM, Gillig JR, Jirousek MR, Ballas LM, Schotten T, Kahl A et al (2003) Acyclic N-(azacycloalkyl) bisindolylmaleimides: isozyme selective inhibitors of PKC-beta. Bioorg Med Chem Lett 13:1857-1859
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 1857-1859
-
-
Faul, M.M.1
Gillig, J.R.2
Jirousek, M.R.3
Ballas, L.M.4
Schotten, T.5
Kahl, A.6
-
4
-
-
23844521568
-
The protein kinase C-beta selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN et al (2005) The protein kinase C-beta selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65:7462-7469
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
Konicek, B.W.4
Lynch, R.L.5
Bailey, S.N.6
-
5
-
-
33745207996
-
The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway
-
Querfeld C, Rizvi MA, Kuzel TM, Guitart J, Rademaker A, Sabharwal SS et al (2006) The selective protein kinase C beta inhibitor enzastaurin induces apoptosis in cutaneous T-cell lymphoma cell lines through the AKT pathway. J Invest Dermatol 126:1641-1647
-
(2006)
J Invest Dermatol
, vol.126
, pp. 1641-1647
-
-
Querfeld, C.1
Rizvi, M.A.2
Kuzel, T.M.3
Guitart, J.4
Rademaker, A.5
Sabharwal, S.S.6
-
6
-
-
34249746834
-
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia
-
Moreau AS, Jia X, Ngo HT, Leleu X, O'Sullivan G, Alsayed Y et al (2007) Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia. Blood 109:4964-4972
-
(2007)
Blood
, vol.109
, pp. 4964-4972
-
-
Moreau, A.S.1
Jia, X.2
Ngo, H.T.3
Leleu, X.4
O'Sullivan, G.5
Alsayed, Y.6
-
7
-
-
33846914141
-
Targeting PKC in multiple myeloma: In vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
-
Podar K, Raab MS, Zhang J, McMillin D, Breitkreutz I, Tai YT et al (2007) Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood 109:1669-1677
-
(2007)
Blood
, vol.109
, pp. 1669-1677
-
-
Podar, K.1
Raab, M.S.2
Zhang, J.3
McMillin, D.4
Breitkreutz, I.5
Tai, Y.T.6
-
8
-
-
49849099068
-
Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C beta inhibitor, in non-small cell lung cancer cells
-
Morgillo F, Martinelli E, Troiani T, Laus G, Pepe S, Gridelli C et al (2008) Sequence-dependent, synergistic antiproliferative and proapoptotic effects of the combination of cytotoxic drugs and enzastaurin, a protein kinase C beta inhibitor, in non-small cell lung cancer cells. Mol Cancer Ther 7:1698-1707
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1698-1707
-
-
Morgillo, F.1
Martinelli, E.2
Troiani, T.3
Laus, G.4
Pepe, S.5
Gridelli, C.6
-
9
-
-
40949101463
-
Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells
-
Lee KW, Kim SG, Kim HP, Kwon E, You J, Choi HJ et al (2008) Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells. Cancer Res 68:1916-1926
-
(2008)
Cancer Res
, vol.68
, pp. 1916-1926
-
-
Lee, K.W.1
Kim, S.G.2
Kim, H.P.3
Kwon, E.4
You, J.5
Choi, H.J.6
-
10
-
-
47649103741
-
The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines
-
Neri A, Marmiroli S, Tassone P, Lombardi L, Nobili L, Verdelli D et al (2008) The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. Leuk Lymphoma 49:1374-1383
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 1374-1383
-
-
Neri, A.1
Marmiroli, S.2
Tassone, P.3
Lombardi, L.4
Nobili, L.5
Verdelli, D.6
-
11
-
-
77953212331
-
Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines
-
Civallero M, Cosenza M, Grisendi G, Marcheselli L, Todoerti K, Sacchi S (2010) Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines. Leuk Lymphoma 51:671-679
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 671-679
-
-
Civallero, M.1
Cosenza, M.2
Grisendi, G.3
Marcheselli, L.4
Todoerti, K.5
Sacchi, S.6
-
12
-
-
0036839013
-
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma
-
Richardson PG, Schlossman RL,Weller E, Hideshima T, Mitsiades C, Davies F et al (2002) Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood 100:3063-3067
-
(2002)
Blood
, vol.100
, pp. 3063-3067
-
-
Richardson, P.G.1
Schlossman, R.L.2
Weller, E.3
Hideshima, T.4
Mitsiades, C.5
Davies, F.6
-
13
-
-
13444256401
-
Efficacy of Lenalidomide in myelodysplastic syndromes
-
List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D et al (2005) Efficacy of Lenalidomide in myelodysplastic syndromes. N Engl J Med 352:549-557
-
(2005)
N Engl J Med
, vol.352
, pp. 549-557
-
-
List, A.1
Kurtin, S.2
Roe, D.J.3
Buresh, A.4
Mahadevan, D.5
Fuchs, D.6
-
14
-
-
74949083498
-
Efficacy of Lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics
-
Sher T, Miller KC, Lawrence D, Whitworth A, Hernandez-Ilizaliturri F, Czuczman MS et al (2010) Efficacy of Lenalidomide in patients with chronic lymphocytic leukemia with high-risk cytogenetics. Leuk Lymphoma 51:85-88
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 85-88
-
-
Sher, T.1
Miller, K.C.2
Lawrence, D.3
Whitworth, A.4
Hernandez-Ilizaliturri, F.5
Czuczman, M.S.6
-
15
-
-
45949100928
-
Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
-
Ferrajoli A, Lee BN, Schlette EJ, O'Brien SM, Gao H, Wen S et al (2008) Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 111:5291-5297
-
(2008)
Blood
, vol.111
, pp. 5291-5297
-
-
Ferrajoli, A.1
Lee, B.N.2
Schlette, E.J.3
O'Brien, S.M.4
Gao, H.5
Wen, S.6
-
18
-
-
36349010285
-
Lenalidomide plus Dexamethasone for relapsed multiple myeloma in North America
-
Weber DM, Chen C, Niesvizky R, Wang M, Belch A, Stadtmauer EA et al (2007) Lenalidomide plus Dexamethasone for relapsed multiple myeloma in North America. N Engl J Med 357:2133-2142
-
(2007)
N Engl J Med
, vol.357
, pp. 2133-2142
-
-
Weber, D.M.1
Chen, C.2
Niesvizky, R.3
Wang, M.4
Belch, A.5
Stadtmauer, E.A.6
-
19
-
-
33749438404
-
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
-
List A, Gordon D, Bennett J, Giagounidis A, Raza A, Feldman E et al (2006) Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 355:1456-1465
-
(2006)
N Engl J Med
, vol.355
, pp. 1456-1465
-
-
List, A.1
Gordon, D.2
Bennett, J.3
Giagounidis, A.4
Raza, A.5
Feldman, E.6
-
20
-
-
0034331194
-
Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
-
Hideshima T, Chauhan D, Shima Y, Raje N, Davies FE, Tai YT et al (2000) Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 96:2943-2950
-
(2000)
Blood
, vol.96
, pp. 2943-2950
-
-
Hideshima, T.1
Chauhan, D.2
Shima, Y.3
Raje, N.4
Davies, F.E.5
Tai, Y.T.6
-
21
-
-
1942534043
-
The evolution of thalidomide and its IMiD derivatives as anticancer agents
-
Bartlett JB, Dredge K, Dalgleish AG (2004) The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 4:314-322
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 314-322
-
-
Bartlett, J.B.1
Dredge, K.2
Dalgleish, A.G.3
-
22
-
-
52549088421
-
Immunomodulatory drugs Revlimid (Lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation
-
Zhu D, Corral LG, Fleming YW, Stein B (2008) Immunomodulatory drugs Revlimid (Lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunol Immunother 57:1849-1859
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1849-1859
-
-
Zhu, D.1
Corral, L.G.2
Fleming, Y.W.3
Stein, B.4
-
23
-
-
33846665934
-
Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
-
Verhelle D, Corral LG,Wong K, Mueller JH, Moutouh-de Parseval L, Jensen-Pergakes K et al (2007) Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. Cancer Res 67:746-755
-
(2007)
Cancer Res
, vol.67
, pp. 746-755
-
-
Verhelle, D.1
Corral Lgwong, K.2
Mueller, J.H.3
Moutouh-De Parseval, L.4
Jensen-Pergakes, K.5
-
24
-
-
33744536515
-
Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assembly
-
Gandhi AK, Kang J, Naziruddin S, Parton A, Schafer PH, Stirling DI (2006) Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assembly. Leuk Res 30:849-858
-
(2006)
Leuk Res
, vol.30
, pp. 849-858
-
-
Gandhi, A.K.1
Kang, J.2
Naziruddin, S.3
Parton, A.4
Schafer, P.H.5
Stirling, D.I.6
-
25
-
-
0019051838
-
Long-term culture of human bone marrow cells
-
Gartner S, Kaplan HS (1980) Long-term culture of human bone marrow cells. Proc Natl Acad Sci U S A 77:4756-4759
-
(1980)
Proc Natl Acad Sci U S A
, vol.77
, pp. 4756-4759
-
-
Gartner, S.1
Kaplan, H.S.2
-
26
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27-55
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
27
-
-
33748794547
-
Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
-
Chou TC (2006) Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58:621-681
-
(2006)
Pharmacol Rev
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
28
-
-
0033801694
-
Basis for effective combination cancer chemotherapy with antimetabolites
-
Peters GJ, van der Wilt CL, van Moorsel CJ, Kroep JR, Bergman AM, Ackland SP (2000) Basis for effective combination cancer chemotherapy with antimetabolites. Pharmacol Ther 87:227-253
-
(2000)
Pharmacol Ther
, vol.87
, pp. 227-253
-
-
Peters, G.J.1
Van Der Wilt, C.L.2
Van Moorsel, C.J.3
Kroep, J.R.4
Bergman, A.M.5
Ackland, S.P.6
-
29
-
-
56449128746
-
New drugs in multiple myeloma: Mechanisms of action and phase I/II clinical findings
-
Ocio EM, Mateos MV, Maiso P, Pandiella A, San-Miguel JF (2008) New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. Lancet Oncol 9:1157-1165
-
(2008)
Lancet Oncol
, vol.9
, pp. 1157-1165
-
-
Ocio, E.M.1
Mateos, M.V.2
Maiso, P.3
Pandiella, A.4
San-Miguel, J.F.5
-
30
-
-
2942613823
-
Chemotherapy combination treatment regimens with fludarabine in chronic lymphocytic leukemia
-
Hallek M, Eichhorst BF (2004) Chemotherapy combination treatment regimens with fludarabine in chronic lymphocytic leukemia. Hematol J 5:20-30
-
(2004)
Hematol J
, vol.5
, pp. 20-30
-
-
Hallek, M.1
Eichhorst, B.F.2
-
31
-
-
33751365495
-
Survival benefits with diverse chemotherapy regimens for ovarian cancer: Meta-analysis of multiple treatments
-
Kyrgiou M, Salanti G, Pavlidis N, Paraskevaidis E, Ioannidis JP (2006) Survival benefits with diverse chemotherapy regimens for ovarian cancer: meta-analysis of multiple treatments. J Natl Cancer Inst 98:1655-1663
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1655-1663
-
-
Kyrgiou, M.1
Salanti, G.2
Pavlidis, N.3
Paraskevaidis, E.4
Ioannidis, J.P.5
-
32
-
-
58049217470
-
Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer
-
Mauri D, Polyzos NP, Salanti G, Pavlidis N, Ioannidis JP (2008) Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer. J Natl Cancer Inst 100:1780-1791
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1780-1791
-
-
Mauri, D.1
Polyzos, N.P.2
Salanti, G.3
Pavlidis, N.4
Ioannidis, J.P.5
-
34
-
-
33748670455
-
Phase i dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer
-
Carducci MA, Musib L, Kies MS, Pili R, Truong M, Brahmer JR et al (2006) Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer. J Clin Oncol 24:4092-4099
-
(2006)
J Clin Oncol
, vol.24
, pp. 4092-4099
-
-
Carducci, M.A.1
Musib, L.2
Kies, M.S.3
Pili, R.4
Truong, M.5
Brahmer, J.R.6
-
35
-
-
34249075706
-
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma
-
Robertson MJ, Kahl BS, Vose JM, de Vos S, Laughlin M, Flynn PJ et al (2007) Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol 25:1741-1746
-
(2007)
J Clin Oncol
, vol.25
, pp. 1741-1746
-
-
Robertson, M.J.1
Kahl, B.S.2
Vose, J.M.3
De Vos, S.4
Laughlin, M.5
Flynn, P.J.6
-
36
-
-
38949178850
-
A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma
-
Morschhauser F, Seymour JF, Kluin-Nelemans HC, Grigg A, Wolf M, Pfreundschuh M et al (2008) A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. Ann Oncol 19:247-253
-
(2008)
Ann Oncol
, vol.19
, pp. 247-253
-
-
Morschhauser, F.1
Seymour, J.F.2
Kluin-Nelemans, H.C.3
Grigg, A.4
Wolf, M.5
Pfreundschuh, M.6
-
37
-
-
34547687425
-
Phase i pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer
-
Rademaker-Lakhai JM, Beerepoot LV, Mehra N, Radema SA, van Maanen R, Vermaat JS et al (2007) Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin Cancer Res 13:4474-4481
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4474-4481
-
-
Rademaker-Lakhai, J.M.1
Beerepoot, L.V.2
Mehra, N.3
Radema, S.A.4
Van Maanen, R.5
Vermaat, J.S.6
-
38
-
-
77956321373
-
Rituximab-Lenalidomide-dexamethasone induces complete and durable remission in relapsed refractory diffuse large Bcell non-Hodgkin lymphoma
-
Ivanov V, Tabouret E, Chuto G, Chetaille B, Fezoui H, Coso D et al (2010) Rituximab-Lenalidomide-dexamethasone induces complete and durable remission in relapsed refractory diffuse large Bcell non-Hodgkin lymphoma. Leuk Lymphoma 51(9):1758-1760
-
(2010)
Leuk Lymphoma
, vol.51
, Issue.9
, pp. 1758-1760
-
-
Ivanov, V.1
Tabouret, E.2
Chuto, G.3
Chetaille, B.4
Fezoui, H.5
Coso, D.6
-
39
-
-
73949145763
-
Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma
-
Witzig TE, Wiernik PH, Moore T, Reeder C, Cole C, Justice G et al (2009) Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma. J Clin Oncol 27:5404-5409
-
(2009)
J Clin Oncol
, vol.27
, pp. 5404-5409
-
-
Witzig, T.E.1
Wiernik, P.H.2
Moore, T.3
Reeder, C.4
Cole, C.5
Justice, G.6
-
40
-
-
79952853727
-
Complete response rates with Lenalidomide plus rituximab for untreated indolent B-cell non- Hodgkin's lymphoma
-
Abstract 8036
-
Fowler NH, McLaughlin P, Hagemeister FB, Kwak LW, Fanale MA, Neelapu SS, et al (2010) Complete response rates with Lenalidomide plus rituximab for untreated indolent B-cell non- Hodgkin's lymphoma. J Clin Oncol 28; Abstract 8036
-
(2010)
J Clin Oncol
, vol.28
-
-
Fowler, N.H.1
McLaughlin, P.2
Hagemeister, F.B.3
Kwak, L.W.4
Fanale, M.A.5
Neelapu, S.S.6
|