Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance in high-fat diet-fed mice

Journal of Medicinal Food

Volumn 15, Issue 10, 2012, Pages 909-916

  Hu, Xiaoqian ^a   Li, Zhaojie ^a   Xue, Yong ^a   Xu, Jie ^a   Xue, Changhu ^a   Wang, Jingfeng ^a   Wang, Yuming ^a  

^a OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

diabetes; hepatic steatosis; inflammation; obesity; saponins

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; SAPONIN; SAPONINS OF SEA CUCUMBER; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PEARSONOTHURIA GRAEFFEI; PRIORITY JOURNAL; SEA CUCUMBER; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WEIGHT REDUCTION;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; CHOLESTEROL, HDL; DIET, HIGH-FAT; FATTY LIVER; GLUCOSE INTOLERANCE; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; SAPONINS; SEA CUCUMBERS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 84867302330     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2011.2042     Document Type: Article

References (28)

1. Spiegelman BM, Flier JS: Obesity and the regulation of energy balance. Cell 2001;104:531-543.
2. Wellen KE, Hotamisligil GS: Inflammation, stress, and diabetes. J Clin Invest 2005;115:1111-1119.
3. Cornier MA, Dabelea D, Hernandez TL, et al.: The metabolic syndrome. Endocr Rev 2008;29:777-822.
4. Kotronen A, Yki-Järvinen H: Fatty liver: A novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 2008; 28:27-38.
5. Takashi H, Nobuhiro Z, Kyoko Y, Ryoko N, Xue C, Tatsuya S: Recent advances in researches on physiologically active substances in holothurians. J Ocean Univ China 2005;4: 193-197.
6. Kalinin VI: System-theoretical (Holistic) approach to the modelling of structural-functional relationships of biomolecules and their evolution: an example of triterpene glycosides from sea cucumbers (Echinodermata, Holothurioidea). J Theor Biol 2000;206:151-168.
7. Tian F, Zhang XW, Tong YG, Yi YH: PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and antitumor activities in vitro and in vivo. Cancer Biol Ther 2005;4: 874-884.
8. Zou ZR, Yi YH, Wu HM, Wu JH, Liaw CC, Lee KH: Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert. J Nat Prod 2003;66:1055-1060.
9. Hu XQ, Wang YM, Wang JF, et al.: Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. Lipids Health Dis 2010; 9:25.
10. Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep 1966;50:219-244.
11. Mlinar B, Marc J, Janez A, Pfeifer M: Molecular mechanisms of insulin resistance and associated diseases. Clin Chim Acta 2007; 375:20-35.
12. Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497-509.
13. Samuel VT, Liu ZX, Qu X, et al.: Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004;279:32345-32353.
14. Hu FB, Manson JE, Willett WC: Types of dietary fat and risk of coronary heart disease: a critical review. J Am Coll Nutr 2001; 20:5-19.
15. Youssef WI, McCullough AJ: Steatohepatitis in obese individuals. Best Pract Res Clin Gastroenterol 2002;16:733-747.
16. Garg A, Misra A: Hepatic steatosis, insulin resistance, and adipose tissue disorders. J Clin Endocrinol Metab 2002;87:3019-3022.
17. Boden G: Free fatty acids-the link between obesity and insulin resistance. Endocr Pract 2001;7:44-51.
18. Wu CH, Yang MY, Chan KC, Chung PJ, Ou TT, Wang CJ: Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice. J Agric Food Chem 2010;58:7075-7081.
19. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997;389:610-614.
20. Winzell MS, Ahrén B: The high-fat diet-fed mouse: A model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 2004;53:S215-2S19.
21. Wellen KE, Hotamisligil GS: Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003;112:1785-1788.
22. Rosen ED, Spiegelman BM: Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006;444: 847-853.
23. Li L, Wu L, Wang C, Liu L, Zhao Y: Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes. Regul Pept 2007;139:72-79.
24. Kahn SE, Hull, RL, Utzschneider KM: Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444:840-846.
25. Fantuzzi G: Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005;115:911-919.
26. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116: 1784-1792.
27. Picardi PK, Caricilli AM, de Abreu LL, Carvalheira JB, Velloso LA, Saad MJ: Modulation of hypothalamic PTP1B in the TNFalpha-induced insulin and leptin resistance. FEBS Lett 2010;584: 3179-3184.
28. Whitehead JP, Richards AA, Hickman IJ, Macdonald GA, Prins JB: Adiponectin-a key adipokine in the metabolic syndrome. Diabetes Obes Metab 2006;8:264-280.